Molecules 2011, 16(3), 2084-2096; doi:10.3390/molecules16032084
Article

Luteolin Isolated from the Medicinal Plant Elsholtzia rugulosa (Labiatae) Prevents Copper-Mediated Toxicity in β-Amyloid Precursor Protein Swedish Mutation Overexpressing SH-SY5Y Cells

1 Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China 2 Xuanwu Hospital Capital Medical University, Beijing 100053, China
* Author to whom correspondence should be addressed.
Received: 14 February 2011; in revised form: 22 February 2011 / Accepted: 25 February 2011 / Published: 2 March 2011
(This article belongs to the Section Natural Products)
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Abstract: Luteolin, a 3’,4’,5,7-tetrahydroxyflavone, is a plant flavonoid and pharmacologically active agent that has been isolated from several plant species. In the present study, the effects of luteolin obtained from the medicinal plant Elsholtzia rugulosa and the related mechanisms were examined in an Alzheimer's disease (AD) cell model. In this model, copper was used to exacerbate the neurotoxicity in β-amyloid precursor protein Swedish mutation stably overexpressed SH-SY5Y cells (named “APPsw cells” for short). Based on this model, we demonstrated that luteolin increased cell viability, reduced intracellular ROS generation, enhanced the activity of SOD and reversed mitochondrial membrane potential dissipation. Inhibition of caspase-related apoptosis was consistently involved in the neuroprotection afforded by luteolin. Furthermore, it down-regulated the expression of AβPP and lowered the secretion of Aβ1-42. These results indicated that luteolin from the Elsholtzia rugulosa exerted neroprotective effects through mechanisms that decrease AβPP expression, lower Aβ secretion, regulate the redox imbalance, preserve mitochondrial function, and depress the caspase family-related apoptosis.
Keywords: Elsholtzia rugulosa; luteolin; Alzheimer’s disease; amyloid-β peptide; copper

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MDPI and ACS Style

Liu, R.; Meng, F.; Zhang, L.; Liu, A.; Qin, H.; Lan, X.; Li, L.; Du, G. Luteolin Isolated from the Medicinal Plant Elsholtzia rugulosa (Labiatae) Prevents Copper-Mediated Toxicity in β-Amyloid Precursor Protein Swedish Mutation Overexpressing SH-SY5Y Cells. Molecules 2011, 16, 2084-2096.

AMA Style

Liu R, Meng F, Zhang L, Liu A, Qin H, Lan X, Li L, Du G. Luteolin Isolated from the Medicinal Plant Elsholtzia rugulosa (Labiatae) Prevents Copper-Mediated Toxicity in β-Amyloid Precursor Protein Swedish Mutation Overexpressing SH-SY5Y Cells. Molecules. 2011; 16(3):2084-2096.

Chicago/Turabian Style

Liu, Rui; Meng, Fanrui; Zhang, Li; Liu, Ailin; Qin, Hailin; Lan, Xi; Li, Lin; Du, Guanhua. 2011. "Luteolin Isolated from the Medicinal Plant Elsholtzia rugulosa (Labiatae) Prevents Copper-Mediated Toxicity in β-Amyloid Precursor Protein Swedish Mutation Overexpressing SH-SY5Y Cells." Molecules 16, no. 3: 2084-2096.

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