Abstract: The anticipated worldwide increase in biodiesel production will result in an accumulation of glycerol for which there are insufficient conventional uses. The surplus of this by-product has increased rapidly during the last decade, prompting a search for new glycerol applications. We describe here the synthesis of dissymmetric chlorohydrin esters from symmetric 1,3-dichloro-2-propyl esters obtained from glycerol. We studied the influence of two solvents: 1,4-dioxane and 1-butanol and two bases: sodium carbonate and 1-butylimidazole, on the synthesis of dissymmetric chlorohydrin esters. In addition, we studied the influence of other bases (potassium and lithium carbonates) in the reaction using 1,4-dioxane as the solvent. The highest yield was obtained using 1,4-dioxane and sodium carbonate.
This is an open access article distributed under the
Creative Commons Attribution License which permits unrestricted use, distribution,
and reproduction in any medium, provided the original work is properly cited.
Export to BibTeX
MDPI and ACS Style
Solarte, C.; Escribà, M.; Eras, J.; Villorbina, G.; Canela, R.; Balcells, M. From Symmetric Glycerol Derivatives to Dissymmetric Chlorohydrins. Molecules 2011, 16, 2065-2074.
Solarte C, Escribà M, Eras J, Villorbina G, Canela R, Balcells M. From Symmetric Glycerol Derivatives to Dissymmetric Chlorohydrins. Molecules. 2011; 16(3):2065-2074.
Solarte, Carmen; Escribà, Marc; Eras, Jordi; Villorbina, Gemma; Canela, Ramon; Balcells, Mercè. 2011. "From Symmetric Glycerol Derivatives to Dissymmetric Chlorohydrins." Molecules 16, no. 3: 2065-2074.