Next Article in Journal
Synthesis, Characterization and Biological Evaluation of Succinate Prodrugs of Curcuminoids for Colon Cancer Treatment
Previous Article in Journal
The Ups and Downs of Tannins as Inhibitors of Poly(ADP-Ribose)glycohydrolase
Molecules 2011, 16(2), 1878-1887; doi:10.3390/molecules16021878

Tin (IV) Chloride-Promoted One-Pot Synthesis of Novel Tacrine Analogues

* , , , ,  and
College of Pharmaceutical and Chemical Engineering, Taizhou University, Linhai 317000, China
* Author to whom correspondence should be addressed.
Received: 5 January 2011 / Revised: 13 January 2011 / Accepted: 15 February 2011 / Published: 22 February 2011
Download PDF [157 KB, uploaded 18 June 2014]


A facile synthesis of potential acetylcholinesterase (AChE) inhibitors, the tacrine analogues 3a-p, has been accomplished by direct cyclocondensation of 1-aryl-4-cyano-5-aminopyrazole with β-ketoesters using tin(IV) chloride as catalyst. The structures of all the compounds have been confirmed by IR, 1H- and 13C-NMR.
Keywords: Alzheimer’s disease; tacrine; tin(IV) chloride; cyclocondensation Alzheimer’s disease; tacrine; tin(IV) chloride; cyclocondensation
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
MDPI and ACS Style

Hu, H.; Song, L.; Fang, Q.; Zheng, J.; Meng, Z.; Luo, Y. Tin (IV) Chloride-Promoted One-Pot Synthesis of Novel Tacrine Analogues. Molecules 2011, 16, 1878-1887.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


Cited By

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert