Molecules 2011, 16(2), 1878-1887; doi:10.3390/molecules16021878
Article

Tin (IV) Chloride-Promoted One-Pot Synthesis of Novel Tacrine Analogues

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Received: 5 January 2011; in revised form: 13 January 2011 / Accepted: 15 February 2011 / Published: 22 February 2011
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: A facile synthesis of potential acetylcholinesterase (AChE) inhibitors, the tacrine analogues 3a-p, has been accomplished by direct cyclocondensation of 1-aryl-4-cyano-5-aminopyrazole with β-ketoesters using tin(IV) chloride as catalyst. The structures of all the compounds have been confirmed by IR, 1H- and 13C-NMR.
Keywords: Alzheimer’s disease; tacrine; tin(IV) chloride; cyclocondensation
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MDPI and ACS Style

Hu, H.; Song, L.; Fang, Q.; Zheng, J.; Meng, Z.; Luo, Y. Tin (IV) Chloride-Promoted One-Pot Synthesis of Novel Tacrine Analogues. Molecules 2011, 16, 1878-1887.

AMA Style

Hu H, Song L, Fang Q, Zheng J, Meng Z, Luo Y. Tin (IV) Chloride-Promoted One-Pot Synthesis of Novel Tacrine Analogues. Molecules. 2011; 16(2):1878-1887.

Chicago/Turabian Style

Hu, Huanan; Song, Liangfu; Fang, Qianqian; Zheng, Junjun; Meng, Zhiwei; Luo, Yiting. 2011. "Tin (IV) Chloride-Promoted One-Pot Synthesis of Novel Tacrine Analogues." Molecules 16, no. 2: 1878-1887.


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