Molecules 2011, 16(2), 1878-1887; doi:10.3390/molecules16021878
Article

Tin (IV) Chloride-Promoted One-Pot Synthesis of Novel Tacrine Analogues

College of Pharmaceutical and Chemical Engineering, Taizhou University, Linhai 317000, China
* Author to whom correspondence should be addressed.
Received: 5 January 2011; in revised form: 13 January 2011 / Accepted: 15 February 2011 / Published: 22 February 2011
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Abstract: A facile synthesis of potential acetylcholinesterase (AChE) inhibitors, the tacrine analogues 3a-p, has been accomplished by direct cyclocondensation of 1-aryl-4-cyano-5-aminopyrazole with β-ketoesters using tin(IV) chloride as catalyst. The structures of all the compounds have been confirmed by IR, 1H- and 13C-NMR.
Keywords: Alzheimer’s disease; tacrine; tin(IV) chloride; cyclocondensation

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MDPI and ACS Style

Hu, H.; Song, L.; Fang, Q.; Zheng, J.; Meng, Z.; Luo, Y. Tin (IV) Chloride-Promoted One-Pot Synthesis of Novel Tacrine Analogues. Molecules 2011, 16, 1878-1887.

AMA Style

Hu H, Song L, Fang Q, Zheng J, Meng Z, Luo Y. Tin (IV) Chloride-Promoted One-Pot Synthesis of Novel Tacrine Analogues. Molecules. 2011; 16(2):1878-1887.

Chicago/Turabian Style

Hu, Huanan; Song, Liangfu; Fang, Qianqian; Zheng, Junjun; Meng, Zhiwei; Luo, Yiting. 2011. "Tin (IV) Chloride-Promoted One-Pot Synthesis of Novel Tacrine Analogues." Molecules 16, no. 2: 1878-1887.

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