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Molecules 2011, 16(2), 1878-1887; doi:10.3390/molecules16021878

Tin (IV) Chloride-Promoted One-Pot Synthesis of Novel Tacrine Analogues

* , , , ,  and
College of Pharmaceutical and Chemical Engineering, Taizhou University, Linhai 317000, China
* Author to whom correspondence should be addressed.
Received: 5 January 2011 / Revised: 13 January 2011 / Accepted: 15 February 2011 / Published: 22 February 2011
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A facile synthesis of potential acetylcholinesterase (AChE) inhibitors, the tacrine analogues 3a-p, has been accomplished by direct cyclocondensation of 1-aryl-4-cyano-5-aminopyrazole with β-ketoesters using tin(IV) chloride as catalyst. The structures of all the compounds have been confirmed by IR, 1H- and 13C-NMR.
Keywords: Alzheimer’s disease; tacrine; tin(IV) chloride; cyclocondensation Alzheimer’s disease; tacrine; tin(IV) chloride; cyclocondensation
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Hu, H.; Song, L.; Fang, Q.; Zheng, J.; Meng, Z.; Luo, Y. Tin (IV) Chloride-Promoted One-Pot Synthesis of Novel Tacrine Analogues. Molecules 2011, 16, 1878-1887.

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