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Molecules 2011, 16(2), 1508-1518; doi:10.3390/molecules16021508

Polycationic Glycosides

1
Department of Chemistry and Biochemistry, Queens College of the City University of New York, 65-30 Kissena Boulevard, Flushing, NY 11367, USA
2
Department of Chemistry and Physical Sciences, Pace University, 1 Pace Plaza, New York, NY 10038, USA
3
Department of Biology, Long Island University, C.W. Post Campus, 720 Northern Boulevard, Greenville, NY 11548, USA
*
Author to whom correspondence should be addressed.
Received: 23 December 2010 / Revised: 7 February 2011 / Accepted: 10 February 2011 / Published: 11 February 2011
(This article belongs to the Special Issue Glycosides)
Download PDF [225 KB, 18 June 2014; original version 18 June 2014]   |  

Abstract

Cationic lipids have long been known to serve as antibacterial and antifungal agents. Prior efforts with attachment of cationic lipids to carbohydrate-based surfaces have suggested the possibility that carbohydrate-attached cationic lipids might serve as antibacterial and antifungal pharmaceutical agents. Toward the understanding of this possibility, we have synthesized several series of cationic lipids attached to a variety of glycosides with the intent of generating antimicrobial agents that would meet the requirement for serving as a pharmaceutical agent, specifically that the agent be effective at a very low concentration as well as being biodegradable within the organism being treated. The initial results of our approach to this goal are presented.
Keywords: polycationic lipid; glycoside; cyclodextrin; starch; 1,4-diazabicyclo[2.2.2]-octane; antibacterial polycationic lipid; glycoside; cyclodextrin; starch; 1,4-diazabicyclo[2.2.2]-octane; antibacterial
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Engel, R.; Ghani, I.; Montenegro, D.; Thomas, M.; Klaritch-Vrana, B.; Castaño, A.; Friedman, L.; Leb, J.; Rothman, L.; Lee, H.; Capodiferro, C.; Ambinder, D.; Cere, E.; Awad, C.; Sheikh, F.; Rizzo, J.; Nisbett, L.-M.; Testani, E.; Melkonian, K. Polycationic Glycosides. Molecules 2011, 16, 1508-1518.

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