Molecules 2011, 16(2), 1508-1518; doi:10.3390/molecules16021508
Article

Polycationic Glycosides

Robert Engel 1,* email, Ishrat Ghani 1 , Diego Montenegro 1 , Marie Thomas 1 , Barbara Klaritch-Vrana 1 , Alejandra Castaño 1 , Laura Friedman 1 , Jay Leb 1 , Leah Rothman 1 , Heidi Lee 1 , Craig Capodiferro 1 , Daniel Ambinder 1 , Eva Cere 1 , Christopher Awad 1 , Faiza Sheikh 2 , JaimeLee Rizzo 2 email, Lisa-Marie Nisbett 3 , Erika Testani 3  and Karin Melkonian 3 email
1 Department of Chemistry and Biochemistry, Queens College of the City University of New York, 65-30 Kissena Boulevard, Flushing, NY 11367, USA 2 Department of Chemistry and Physical Sciences, Pace University, 1 Pace Plaza, New York, NY 10038, USA 3 Department of Biology, Long Island University, C.W. Post Campus, 720 Northern Boulevard, Greenville, NY 11548, USA
* Author to whom correspondence should be addressed.
Received: 23 December 2010; in revised form: 7 February 2011 / Accepted: 10 February 2011 / Published: 11 February 2011
(This article belongs to the Special Issue Glycosides)
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Abstract: Cationic lipids have long been known to serve as antibacterial and antifungal agents. Prior efforts with attachment of cationic lipids to carbohydrate-based surfaces have suggested the possibility that carbohydrate-attached cationic lipids might serve as antibacterial and antifungal pharmaceutical agents. Toward the understanding of this possibility, we have synthesized several series of cationic lipids attached to a variety of glycosides with the intent of generating antimicrobial agents that would meet the requirement for serving as a pharmaceutical agent, specifically that the agent be effective at a very low concentration as well as being biodegradable within the organism being treated. The initial results of our approach to this goal are presented.
Keywords: polycationic lipid; glycoside; cyclodextrin; starch; 1,4-diazabicyclo[2.2.2]-octane; antibacterial

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Cite This Article

MDPI and ACS Style

Engel, R.; Ghani, I.; Montenegro, D.; Thomas, M.; Klaritch-Vrana, B.; Castaño, A.; Friedman, L.; Leb, J.; Rothman, L.; Lee, H.; Capodiferro, C.; Ambinder, D.; Cere, E.; Awad, C.; Sheikh, F.; Rizzo, J.; Nisbett, L.-M.; Testani, E.; Melkonian, K. Polycationic Glycosides. Molecules 2011, 16, 1508-1518.

AMA Style

Engel R, Ghani I, Montenegro D, Thomas M, Klaritch-Vrana B, Castaño A, Friedman L, Leb J, Rothman L, Lee H, Capodiferro C, Ambinder D, Cere E, Awad C, Sheikh F, Rizzo J, Nisbett L-M, Testani E, Melkonian K. Polycationic Glycosides. Molecules. 2011; 16(2):1508-1518.

Chicago/Turabian Style

Engel, Robert; Ghani, Ishrat; Montenegro, Diego; Thomas, Marie; Klaritch-Vrana, Barbara; Castaño, Alejandra; Friedman, Laura; Leb, Jay; Rothman, Leah; Lee, Heidi; Capodiferro, Craig; Ambinder, Daniel; Cere, Eva; Awad, Christopher; Sheikh, Faiza; Rizzo, JaimeLee; Nisbett, Lisa-Marie; Testani, Erika; Melkonian, Karin. 2011. "Polycationic Glycosides." Molecules 16, no. 2: 1508-1518.

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