AbstractCationic lipids have long been known to serve as antibacterial and antifungal agents. Prior efforts with attachment of cationic lipids to carbohydrate-based surfaces have suggested the possibility that carbohydrate-attached cationic lipids might serve as antibacterial and antifungal pharmaceutical agents. Toward the understanding of this possibility, we have synthesized several series of cationic lipids attached to a variety of glycosides with the intent of generating antimicrobial agents that would meet the requirement for serving as a pharmaceutical agent, specifically that the agent be effective at a very low concentration as well as being biodegradable within the organism being treated. The initial results of our approach to this goal are presented.
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Engel, R.; Ghani, I.; Montenegro, D.; Thomas, M.; Klaritch-Vrana, B.; Castaño, A.; Friedman, L.; Leb, J.; Rothman, L.; Lee, H.; Capodiferro, C.; Ambinder, D.; Cere, E.; Awad, C.; Sheikh, F.; Rizzo, J.; Nisbett, L.-M.; Testani, E.; Melkonian, K. Polycationic Glycosides. Molecules 2011, 16, 1508-1518.
Engel R, Ghani I, Montenegro D, Thomas M, Klaritch-Vrana B, Castaño A, Friedman L, Leb J, Rothman L, Lee H, Capodiferro C, Ambinder D, Cere E, Awad C, Sheikh F, Rizzo J, Nisbett L-M, Testani E, Melkonian K. Polycationic Glycosides. Molecules. 2011; 16(2):1508-1518.Chicago/Turabian Style
Engel, Robert; Ghani, Ishrat; Montenegro, Diego; Thomas, Marie; Klaritch-Vrana, Barbara; Castaño, Alejandra; Friedman, Laura; Leb, Jay; Rothman, Leah; Lee, Heidi; Capodiferro, Craig; Ambinder, Daniel; Cere, Eva; Awad, Christopher; Sheikh, Faiza; Rizzo, JaimeLee; Nisbett, Lisa-Marie; Testani, Erika; Melkonian, Karin. 2011. "Polycationic Glycosides." Molecules 16, no. 2: 1508-1518.