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Molecules 2011, 16(2), 1508-1518; doi:10.3390/molecules16021508
Article

Polycationic Glycosides

1,* , 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1, 2, 2
, 3, 3 and 3
Received: 23 December 2010; in revised form: 7 February 2011 / Accepted: 10 February 2011 / Published: 11 February 2011
(This article belongs to the Special Issue Glycosides)
Download PDF [225 KB, updated 18 June 2014; original version uploaded 18 June 2014]
Abstract: Cationic lipids have long been known to serve as antibacterial and antifungal agents. Prior efforts with attachment of cationic lipids to carbohydrate-based surfaces have suggested the possibility that carbohydrate-attached cationic lipids might serve as antibacterial and antifungal pharmaceutical agents. Toward the understanding of this possibility, we have synthesized several series of cationic lipids attached to a variety of glycosides with the intent of generating antimicrobial agents that would meet the requirement for serving as a pharmaceutical agent, specifically that the agent be effective at a very low concentration as well as being biodegradable within the organism being treated. The initial results of our approach to this goal are presented.
Keywords: polycationic lipid; glycoside; cyclodextrin; starch; 1,4-diazabicyclo[2.2.2]-octane; antibacterial polycationic lipid; glycoside; cyclodextrin; starch; 1,4-diazabicyclo[2.2.2]-octane; antibacterial
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Engel, R.; Ghani, I.; Montenegro, D.; Thomas, M.; Klaritch-Vrana, B.; Castaño, A.; Friedman, L.; Leb, J.; Rothman, L.; Lee, H.; Capodiferro, C.; Ambinder, D.; Cere, E.; Awad, C.; Sheikh, F.; Rizzo, J.; Nisbett, L.-M.; Testani, E.; Melkonian, K. Polycationic Glycosides. Molecules 2011, 16, 1508-1518.

AMA Style

Engel R, Ghani I, Montenegro D, Thomas M, Klaritch-Vrana B, Castaño A, Friedman L, Leb J, Rothman L, Lee H, Capodiferro C, Ambinder D, Cere E, Awad C, Sheikh F, Rizzo J, Nisbett L-M, Testani E, Melkonian K. Polycationic Glycosides. Molecules. 2011; 16(2):1508-1518.

Chicago/Turabian Style

Engel, Robert; Ghani, Ishrat; Montenegro, Diego; Thomas, Marie; Klaritch-Vrana, Barbara; Castaño, Alejandra; Friedman, Laura; Leb, Jay; Rothman, Leah; Lee, Heidi; Capodiferro, Craig; Ambinder, Daniel; Cere, Eva; Awad, Christopher; Sheikh, Faiza; Rizzo, JaimeLee; Nisbett, Lisa-Marie; Testani, Erika; Melkonian, Karin. 2011. "Polycationic Glycosides." Molecules 16, no. 2: 1508-1518.



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