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Triterpene Composition and Bioactivities of Centella asiatica
Halal Products Research Institute, Universiti Putra Malaysia, Putra Infoport, 43400 UPM Serdang, Selangor, Malaysia
Industrial Biotechnology Research Centre, SIRIM Berhad, 1 Persiaran Dato’ Menteri, 40911 Shah Alam, Selangor, Malaysia
School of Medicine and Health Sciences, Monash University Sunway Campus, Jalan Lagoon Selatan, 46150 Bandar Sunway, Selangor, Malaysia
Forest Research Institute Malaysia, 52109, Kepong, Selangor, Malaysia
* Author to whom correspondence should be addressed.
Received: 25 November 2010; in revised form: 4 January 2011 / Accepted: 13 January 2011 / Published: 28 January 2011
Abstract: Leaves of Centella asiatica (Centella) were analysed for their triterpene composition and bioactivity such as collagen enhancement, antioxidant, anticellulite and UV protection capacity properties. Triterpenes of Centella were measured using HPLC-PAD on an Excil ODS 5 mm (C18) column for the simultaneous determination of asiatic acid, madecassic acid, asiaticoside and madecassoside. Centella was found to contain significant amounts of madecassoside (3.10 ± 4.58 mg/mL) and asiaticoside (1.97 ± 2.65 mg/mL), but was low in asiatic and madecassic acid. The highest collagen synthesis was found at 50 mg/mL of Centella extracts. The antioxidant activity of Centella (84%) was compared to grape seed extract (83%) and Vitamin C (88%). Its lipolytic activity was observed by the release of glycerol (115.9 µmol/L) at 0.02% concentration. Centella extracts exhibited similar UV protection effect to OMC at 10% concentration. In view of these results, the potential application of Centella in food and pharmaceutical industries is now widely open.
Keywords: Centella asiatica; triterpenes; collagen; anti-oxidant; UV protection
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MDPI and ACS Style
Hashim, P.; Sidek, H.; Helan, M.H.M.; Sabery, A.; Palanisamy, U.D.; Ilham, M. Triterpene Composition and Bioactivities of Centella asiatica. Molecules 2011, 16, 1310-1322.
Hashim P, Sidek H, Helan MHM, Sabery A, Palanisamy UD, Ilham M. Triterpene Composition and Bioactivities of Centella asiatica. Molecules. 2011; 16(2):1310-1322.
Hashim, Puziah; Sidek, Hamidah; Helan, Mohd H.M.; Sabery, Aidawati; Palanisamy, Uma Devi; Ilham, Mohd. 2011. "Triterpene Composition and Bioactivities of Centella asiatica." Molecules 16, no. 2: 1310-1322.