Molecules 2011, 16(2), 1297-1309; doi:10.3390/molecules16021297
Article

Synthesis, Characterization and Antifungal Evaluation of 5-Substituted-4-Amino-1,2,4-Triazole-3-Thioesters

Received: 14 December 2010; Accepted: 1 December 2010 / Published: 28 January 2011
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: A series of 5-substituted-4-amino-1,2,4-triazole-3-thioesters was synthesized by converting variously substituted organic acids successively into the corresponding esters, hydrazides, 5-substituted-1,3,4-oxadiazole-2-thiols, 5-substituted-1,2,4-triazole-2-thiols and 5-substituted-1,3,4-oxadiazole-2-thioesters. Finally the target compounds were obtained by refluxing 5-substituted-1,3,4-oxadiazole-2-thioesters in the presence of hydrazine hydrate and absolute alcohol. The structures of the synthesized compounds were established by physicochemical and spectroscopic methods. The synthesized compounds were evaluated for their in vitro antifungal activity. Some of the evaluated compounds possessed significant antifungal activity as compared to a terbinafine standard.
Keywords: triazolethioesters; oxadiazolethioesters; oxadiazoles; triazoles; in vitro antifungal activity
PDF Full-text Download PDF Full-Text [204 KB, Updated Version, uploaded 18 June 2014 19:36 CEST]
The original version is still available [169 KB, uploaded 18 June 2014 19:36 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Hasan, A.; Thomas, N.F.; Gapil, S. Synthesis, Characterization and Antifungal Evaluation of 5-Substituted-4-Amino-1,2,4-Triazole-3-Thioesters. Molecules 2011, 16, 1297-1309.

AMA Style

Hasan A, Thomas NF, Gapil S. Synthesis, Characterization and Antifungal Evaluation of 5-Substituted-4-Amino-1,2,4-Triazole-3-Thioesters. Molecules. 2011; 16(2):1297-1309.

Chicago/Turabian Style

Hasan, Aurangzeb; Thomas, Noel Francis; Gapil, Shelly. 2011. "Synthesis, Characterization and Antifungal Evaluation of 5-Substituted-4-Amino-1,2,4-Triazole-3-Thioesters." Molecules 16, no. 2: 1297-1309.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert