Next Article in Journal
Triterpene Composition and Bioactivities of Centella asiatica
Previous Article in Journal
Behaviors in Ethylene Polymerization of MgCl2-SiO2/TiCl4/THF Ziegler-Natta Catalysts with Differently Treated SiO2
Molecules 2011, 16(2), 1297-1309; doi:10.3390/molecules16021297

Synthesis, Characterization and Antifungal Evaluation of 5-Substituted-4-Amino-1,2,4-Triazole-3-Thioesters

* ,  and
Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur-50603, Malaysia
* Author to whom correspondence should be addressed.
Received: 14 December 2010 / Accepted: 1 December 2010 / Published: 28 January 2011
Download PDF [204 KB, 18 June 2014; original version 18 June 2014]   |  


A series of 5-substituted-4-amino-1,2,4-triazole-3-thioesters was synthesized by converting variously substituted organic acids successively into the corresponding esters, hydrazides, 5-substituted-1,3,4-oxadiazole-2-thiols, 5-substituted-1,2,4-triazole-2-thiols and 5-substituted-1,3,4-oxadiazole-2-thioesters. Finally the target compounds were obtained by refluxing 5-substituted-1,3,4-oxadiazole-2-thioesters in the presence of hydrazine hydrate and absolute alcohol. The structures of the synthesized compounds were established by physicochemical and spectroscopic methods. The synthesized compounds were evaluated for their in vitro antifungal activity. Some of the evaluated compounds possessed significant antifungal activity as compared to a terbinafine standard.
Keywords: triazolethioesters; oxadiazolethioesters; oxadiazoles; triazoles; in vitro antifungal activity triazolethioesters; oxadiazolethioesters; oxadiazoles; triazoles; in vitro antifungal activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
MDPI and ACS Style

Hasan, A.; Thomas, N.F.; Gapil, S. Synthesis, Characterization and Antifungal Evaluation of 5-Substituted-4-Amino-1,2,4-Triazole-3-Thioesters. Molecules 2011, 16, 1297-1309.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert