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Molecules 2011, 16(2), 1297-1309; doi:10.3390/molecules16021297

Synthesis, Characterization and Antifungal Evaluation of 5-Substituted-4-Amino-1,2,4-Triazole-3-Thioesters

Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur-50603, Malaysia
Author to whom correspondence should be addressed.
Received: 14 December 2010 / Accepted: 1 December 2010 / Published: 28 January 2011
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A series of 5-substituted-4-amino-1,2,4-triazole-3-thioesters was synthesized by converting variously substituted organic acids successively into the corresponding esters, hydrazides, 5-substituted-1,3,4-oxadiazole-2-thiols, 5-substituted-1,2,4-triazole-2-thiols and 5-substituted-1,3,4-oxadiazole-2-thioesters. Finally the target compounds were obtained by refluxing 5-substituted-1,3,4-oxadiazole-2-thioesters in the presence of hydrazine hydrate and absolute alcohol. The structures of the synthesized compounds were established by physicochemical and spectroscopic methods. The synthesized compounds were evaluated for their in vitro antifungal activity. Some of the evaluated compounds possessed significant antifungal activity as compared to a terbinafine standard.
Keywords: triazolethioesters; oxadiazolethioesters; oxadiazoles; triazoles; in vitro antifungal activity triazolethioesters; oxadiazolethioesters; oxadiazoles; triazoles; in vitro antifungal activity

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Hasan, A.; Thomas, N.F.; Gapil, S. Synthesis, Characterization and Antifungal Evaluation of 5-Substituted-4-Amino-1,2,4-Triazole-3-Thioesters. Molecules 2011, 16, 1297-1309.

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