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Molecules 2011, 16(11), 9017-9024; doi:10.3390/molecules16119017
Article

A New Eudesmane Sesquiterpene Glucoside from Liriope muscari Fibrous Roots

1, 2, 3, 4, 1, 3, 1, 3,* , 1,*  and 4
1 State Key Laboratory of Earth Surface Processes and Resource Ecology, Beijing Normal University, Beijing 100875, China 2 National Institutes for Food and Drug Control, Beijing 100050, China 3 Department of Entomology, China Agricultural University, Haidian District, Beijing 100193, China 4 Analytical and Testing Center, Beijing Normal University, Beijing 100875, China
* Authors to whom correspondence should be addressed.
Received: 16 September 2011 / Revised: 20 October 2011 / Accepted: 24 October 2011 / Published: 26 October 2011
(This article belongs to the Section Metabolites)
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Abstract

The screening of several Chinese medicinal herbs for nematocidal properties showed that the ethanol extract of Liriope muscari fibrous roots possessed significant nematocidal activity against the pine wood nematode (Bursaphelenchus xylophilus). From the ethanol extract, a new constituent (1,4-epoxy-cis-eudesm-6-O-β-D-glucopyranoside) and three known glycosides [1β,6α-dihydroxy-cis-eudesm-3-ene-6-O-β-D-glucopyranoside (liriopeoside A), 1β,6β-dihydroxy-cis-eudesm-3-ene-6-O-β-D-glucopyranoside, and 1α,6β-dihydroxy-5,10-bis-epi-eudesm-4(15)-ene-6-O-β D-glucopyranoside] were isolated by bioassay-guided fractionation. The structures were elucidated by 1D and 2D NMR and MS techniques. 1,4-Epoxy-cis-eudesm-6-O-β-D-glucopyranoside possessed moderate nemato-cidal activity against B. xylophilus with a LC50 value of 339.76 μg/mL, while liriopeoside A (LC50 = 82.84 μg/mL) and 1β,6β-dihydroxy-cis-eudesm-3-ene-6-O-β-D-glucopyranoside (LC50 = 153.39 μg/mL) also exhibited nematocidal activity against B. xylophilus. The crude extract of L. muscari fibrous roots exhibited nematocidal activity against the pine wood nematode with a LC50 value of 182.56 μg/mL.
Keywords: Liriope muscari; Nematocidal activity; Bursaphelenchus xylophilus; 1,4-epoxy-cis-eudesm-6-O-β-D-glucopyranoside Liriope muscari; Nematocidal activity; Bursaphelenchus xylophilus; 1,4-epoxy-cis-eudesm-6-O-β-D-glucopyranoside
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Zhang, H.M.; Wang, G.L.; Bai, C.Q.; Liu, P.; Liu, Z.M.; Liu, Q.Z.; Wang, Y.Y.; Liu, Z.L.; Du, S.S.; Deng, Z.W. A New Eudesmane Sesquiterpene Glucoside from Liriope muscari Fibrous Roots. Molecules 2011, 16, 9017-9024.

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