Molecules 2011, 16(11), 9017-9024; doi:10.3390/molecules16119017
Article

A New Eudesmane Sesquiterpene Glucoside from Liriope muscari Fibrous Roots

Hai Ming Zhang 1 , Gang Li Wang 2 , Chun Qi Bai 3 , Peng Liu 4 , Zi Mu Liu 1 , Qi Zhi Liu 3 , Yong Yan Wang 1 , Zhi Long Liu 3,* email, Shu Shan Du 1,* email and Zhi Wei Deng 4
1 State Key Laboratory of Earth Surface Processes and Resource Ecology, Beijing Normal University, Beijing 100875, China 2 National Institutes for Food and Drug Control, Beijing 100050, China 3 Department of Entomology, China Agricultural University, Haidian District, Beijing 100193, China 4 Analytical and Testing Center, Beijing Normal University, Beijing 100875, China
* Authors to whom correspondence should be addressed.
Received: 16 September 2011; in revised form: 20 October 2011 / Accepted: 24 October 2011 / Published: 26 October 2011
(This article belongs to the Section Natural Products)
PDF Full-text Download PDF Full-Text [238 KB, uploaded 26 October 2011 15:21 CEST]
Abstract: The screening of several Chinese medicinal herbs for nematocidal properties showed that the ethanol extract of Liriope muscari fibrous roots possessed significant nematocidal activity against the pine wood nematode (Bursaphelenchus xylophilus). From the ethanol extract, a new constituent (1,4-epoxy-cis-eudesm-6-O-β-D-glucopyranoside) and three known glycosides [1β,6α-dihydroxy-cis-eudesm-3-ene-6-O-β-D-glucopyranoside (liriopeoside A), 1β,6β-dihydroxy-cis-eudesm-3-ene-6-O-β-D-glucopyranoside, and 1α,6β-dihydroxy-5,10-bis-epi-eudesm-4(15)-ene-6-O-β D-glucopyranoside] were isolated by bioassay-guided fractionation. The structures were elucidated by 1D and 2D NMR and MS techniques. 1,4-Epoxy-cis-eudesm-6-O-β-D-glucopyranoside possessed moderate nemato-cidal activity against B. xylophilus with a LC50 value of 339.76 μg/mL, while liriopeoside A (LC50 = 82.84 μg/mL) and 1β,6β-dihydroxy-cis-eudesm-3-ene-6-O-β-D-glucopyranoside (LC50 = 153.39 μg/mL) also exhibited nematocidal activity against B. xylophilus. The crude extract of L. muscari fibrous roots exhibited nematocidal activity against the pine wood nematode with a LC50 value of 182.56 μg/mL.
Keywords: Liriope muscari; Nematocidal activity; Bursaphelenchus xylophilus; 1,4-epoxy-cis-eudesm-6-O-β-D-glucopyranoside

Supplementary Files

Article Statistics

Click here to load and display the download statistics.

Cite This Article

MDPI and ACS Style

Zhang, H.M.; Wang, G.L.; Bai, C.Q.; Liu, P.; Liu, Z.M.; Liu, Q.Z.; Wang, Y.Y.; Liu, Z.L.; Du, S.S.; Deng, Z.W. A New Eudesmane Sesquiterpene Glucoside from Liriope muscari Fibrous Roots. Molecules 2011, 16, 9017-9024.

AMA Style

Zhang HM, Wang GL, Bai CQ, Liu P, Liu ZM, Liu QZ, Wang YY, Liu ZL, Du SS, Deng ZW. A New Eudesmane Sesquiterpene Glucoside from Liriope muscari Fibrous Roots. Molecules. 2011; 16(11):9017-9024.

Chicago/Turabian Style

Zhang, Hai Ming; Wang, Gang Li; Bai, Chun Qi; Liu, Peng; Liu, Zi Mu; Liu, Qi Zhi; Wang, Yong Yan; Liu, Zhi Long; Du, Shu Shan; Deng, Zhi Wei. 2011. "A New Eudesmane Sesquiterpene Glucoside from Liriope muscari Fibrous Roots." Molecules 16, no. 11: 9017-9024.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert