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Molecules 2011, 16(11), 8992-9002; doi:10.3390/molecules16118992
Article

Synthesis of [(4-Chloro-5H-1,2,3-dithiazol-5-ylidene)amino]azines

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Received: 26 September 2011 / Revised: 21 October 2011 / Accepted: 21 October 2011 / Published: 25 October 2011
(This article belongs to the Special Issue Heterocycles)
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Abstract

The reactions of 2-, 3- and 4-aminopyridines with 4,5-dichloro-1,2,3-dithiazol-ium chloride (Appel salt) 4 to give N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)pyridin-X-amines 1a (X = 2), 1g (X = 3) and 1k (X = 4) were optimized with respect to base, temperature and reaction time. Based on these conditions a total of thirteen [(dithiazol-ylidene)amino]azines 1a-m were prepared and fully characterized.
Keywords: heterocycle; Appel salt; 1,2,3-dithiazoles; condensation; azine heterocycle; Appel salt; 1,2,3-dithiazoles; condensation; azine
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Koutentis, P.A.; Koyioni, M.; Michaelidou, S.S. Synthesis of [(4-Chloro-5H-1,2,3-dithiazol-5-ylidene)amino]azines. Molecules 2011, 16, 8992-9002.

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