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Molecules 2011, 16(11), 8992-9002; doi:10.3390/molecules16118992

Synthesis of [(4-Chloro-5H-1,2,3-dithiazol-5-ylidene)amino]azines

Department of Chemistry, University of Cyprus, P.O. Box 20537, 1678 Nicosia, Cyprus
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Received: 26 September 2011 / Revised: 21 October 2011 / Accepted: 21 October 2011 / Published: 25 October 2011
(This article belongs to the Special Issue Heterocycles)
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Abstract

The reactions of 2-, 3- and 4-aminopyridines with 4,5-dichloro-1,2,3-dithiazol-ium chloride (Appel salt) 4 to give N-(4-chloro-5H-1,2,3-dithiazol-5-ylidene)pyridin-X-amines 1a (X = 2), 1g (X = 3) and 1k (X = 4) were optimized with respect to base, temperature and reaction time. Based on these conditions a total of thirteen [(dithiazol-ylidene)amino]azines 1a-m were prepared and fully characterized.
Keywords: heterocycle; Appel salt; 1,2,3-dithiazoles; condensation; azine heterocycle; Appel salt; 1,2,3-dithiazoles; condensation; azine
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MDPI and ACS Style

Koutentis, P.A.; Koyioni, M.; Michaelidou, S.S. Synthesis of [(4-Chloro-5H-1,2,3-dithiazol-5-ylidene)amino]azines. Molecules 2011, 16, 8992-9002.

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