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One-Pot Synthesis of Novel 2,3-Dihydro-1H-indazoles
Department of Chemistry, Berry College, PO Box 495016, Mount Berry, GA 30101, USA
* Author to whom correspondence should be addressed.
Received: 8 October 2011; in revised form: 8 November 2011 / Accepted: 10 November 2011 / Published: 16 November 2011
Abstract: A copper(I)-mediated one-pot synthesis of 2,3-dihydro-1H-indazole heterocycles has been developed. This synthetic route provides the desired indazoles in moderate to good yields (55%–72%) which are substantially better than those achievable with an alternative two-step reaction sequence. The reaction is tolerant of functionality on the aromatic ring.
Keywords: 2,3-dihydro-1H-indazole; synthesis; heterocycle; indazoles; copper coupling
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Breton, G.W.; Lepore, A.J. One-Pot Synthesis of Novel 2,3-Dihydro-1H-indazoles. Molecules 2011, 16, 9553-9561.
Breton GW, Lepore AJ. One-Pot Synthesis of Novel 2,3-Dihydro-1H-indazoles. Molecules. 2011; 16(11):9553-9561.
Breton, Gary W.; Lepore, Antonio J. 2011. "One-Pot Synthesis of Novel 2,3-Dihydro-1H-indazoles." Molecules 16, no. 11: 9553-9561.