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Molecules 2011, 16(11), 9553-9561; doi:10.3390/molecules16119553
Article

One-Pot Synthesis of Novel 2,3-Dihydro-1H-indazoles

*  and
Received: 8 October 2011 / Revised: 8 November 2011 / Accepted: 10 November 2011 / Published: 16 November 2011
(This article belongs to the Special Issue Heterocycles)
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Abstract

A copper(I)-mediated one-pot synthesis of 2,3-dihydro-1H-indazole heterocycles has been developed. This synthetic route provides the desired indazoles in moderate to good yields (55%–72%) which are substantially better than those achievable with an alternative two-step reaction sequence. The reaction is tolerant of functionality on the aromatic ring.
Keywords: 2,3-dihydro-1H-indazole; synthesis; heterocycle; indazoles; copper coupling 2,3-dihydro-1H-indazole; synthesis; heterocycle; indazoles; copper coupling
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Breton, G.W.; Lepore, A.J. One-Pot Synthesis of Novel 2,3-Dihydro-1H-indazoles. Molecules 2011, 16, 9553-9561.

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