Next Article in Journal
Dissociation of the Disilatricyclic Diallylic Dianion [(C4Ph4SiMe)2]−2 to the Silole Anion [MeSiC4Ph4] by Halide Ion Coordination or Halide Ion Nucleophilic Substitution at the Silicon Atom
Next Article in Special Issue
Pharmacological and Biological Antiviral Therapeutics for Cardiac Coxsackievirus Infections
Previous Article in Journal
Simplified Synthesis of Isotopically Labeled 5,5-Dimethyl-pyrroline N-Oxide
Previous Article in Special Issue
Synthesis of Quinolin-2-one Alkaloid Derivatives and Their Inhibitory Activities against HIV-1 Reverse Transcriptase
Molecules 2011, 16(10), 8437-8450; doi:10.3390/molecules16108437
Article

In Vitro Anti-HMPV Activity of Meroditerpenoids from Marine Alga Stypopodium zonale (Dictyotales)

1,2, 3, 3, 3, 4, 3, 3, 2 and 1,*
Received: 25 July 2011 / Revised: 9 September 2011 / Accepted: 29 September 2011 / Published: 10 October 2011
(This article belongs to the Special Issue Antivirals)
Download PDF [938 KB, uploaded 18 June 2014]

Abstract

In this paper, we evaluated the antiviral activity against HMPV replication of crude extract of the marine algae Stypopodium zonale and of two meroditerpenoids obtained from it, atomaric acid and epitaondiol, and a methyl ester derivative of atomaric acid. Their selectivity indexes were 20.78, >56.81, 49.26 and 12.82, respectively. Compared to ribavirin, the substances showed a relatively low cytotoxicity on LLC-MK2 cells, with a significant antiviral activity, inhibiting at least 90% of viral replication in vitro, which demonstrates the potential of these marine natural products to combat infections caused by HMPV in vitro.
Keywords: HMPV; alga, antiviral; meroditerpenoids; Dictyotaceae HMPV; alga, antiviral; meroditerpenoids; Dictyotaceae
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Mendes, G.; Soares, A.R.; Sigiliano, L.; Machado, F.; Kaiser, C.; Romeiro, N.; Gestinari, L.; Santos, N.; Romanos, M.T.V. In Vitro Anti-HMPV Activity of Meroditerpenoids from Marine Alga Stypopodium zonale (Dictyotales). Molecules 2011, 16, 8437-8450.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

Cited By

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert