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Molecules 2011, 16(10), 8437-8450; doi:10.3390/molecules16108437

In Vitro Anti-HMPV Activity of Meroditerpenoids from Marine Alga Stypopodium zonale (Dictyotales)

1,2, 3, 3, 3, 4, 3, 3, 2 and 1,*
Received: 25 July 2011 / Revised: 9 September 2011 / Accepted: 29 September 2011 / Published: 10 October 2011
(This article belongs to the Special Issue Antivirals)
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In this paper, we evaluated the antiviral activity against HMPV replication of crude extract of the marine algae Stypopodium zonale and of two meroditerpenoids obtained from it, atomaric acid and epitaondiol, and a methyl ester derivative of atomaric acid. Their selectivity indexes were 20.78, >56.81, 49.26 and 12.82, respectively. Compared to ribavirin, the substances showed a relatively low cytotoxicity on LLC-MK2 cells, with a significant antiviral activity, inhibiting at least 90% of viral replication in vitro, which demonstrates the potential of these marine natural products to combat infections caused by HMPV in vitro.
Keywords: HMPV; alga, antiviral; meroditerpenoids; Dictyotaceae HMPV; alga, antiviral; meroditerpenoids; Dictyotaceae
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Mendes, G.; Soares, A.R.; Sigiliano, L.; Machado, F.; Kaiser, C.; Romeiro, N.; Gestinari, L.; Santos, N.; Romanos, M.T.V. In Vitro Anti-HMPV Activity of Meroditerpenoids from Marine Alga Stypopodium zonale (Dictyotales). Molecules 2011, 16, 8437-8450.

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