Molecules 2011, 16(10), 8437-8450; doi:10.3390/molecules16108437
Article

In Vitro Anti-HMPV Activity of Meroditerpenoids from Marine Alga Stypopodium zonale (Dictyotales)

1 Laboratório Experimental de Drogas Antivirais e Citotóxicas (LEDAC), Departamento de Virologia do, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro (UFRJ), CCS, Bloco I, Caixa Postal 68040, 21941-590 Rio de Janeiro, RJ, Brasil 2 Laboratório de Viroses Respiratórias, Entéricas e Oculares, Departamento de Virologia do Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro (UFRJ), CCS, Bloco I, Caixa Postal 68040, 21941-590 Rio de Janeiro, RJ, Brasil 3 Grupo de Produtos Naturais de Organismos Aquáticos (GPNOA), Núcleo em Ecologia e Desenvolvimento Socioambiental de Macaé (NUPEM), Universidade Federal do Rio de Janeiro (UFRJ), CCS, Bloco I, Caixa Postal 68040, 21941-590 Rio de Janeiro, RJ, Brasil 4 Instituto de Química, Universidade Federal do Rio de Janeiro (UFRJ), CCS, Bloco I, Caixa Postal 68040, 21941-590 Rio de Janeiro, RJ, Brasil
* Author to whom correspondence should be addressed.
Received: 25 July 2011; in revised form: 9 September 2011 / Accepted: 29 September 2011 / Published: 10 October 2011
(This article belongs to the Special Issue Antivirals)
PDF Full-text Download PDF Full-Text [938 KB, uploaded 10 October 2011 09:49 CEST]
Abstract: In this paper, we evaluated the antiviral activity against HMPV replication of crude extract of the marine algae Stypopodium zonale and of two meroditerpenoids obtained from it, atomaric acid and epitaondiol, and a methyl ester derivative of atomaric acid. Their selectivity indexes were 20.78, >56.81, 49.26 and 12.82, respectively. Compared to ribavirin, the substances showed a relatively low cytotoxicity on LLC-MK2 cells, with a significant antiviral activity, inhibiting at least 90% of viral replication in vitro, which demonstrates the potential of these marine natural products to combat infections caused by HMPV in vitro.
Keywords: HMPV; alga, antiviral; meroditerpenoids; Dictyotaceae

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Mendes, G.; Soares, A.R.; Sigiliano, L.; Machado, F.; Kaiser, C.; Romeiro, N.; Gestinari, L.; Santos, N.; Romanos, M.T.V. In Vitro Anti-HMPV Activity of Meroditerpenoids from Marine Alga Stypopodium zonale (Dictyotales). Molecules 2011, 16, 8437-8450.

AMA Style

Mendes G, Soares AR, Sigiliano L, Machado F, Kaiser C, Romeiro N, Gestinari L, Santos N, Romanos MTV. In Vitro Anti-HMPV Activity of Meroditerpenoids from Marine Alga Stypopodium zonale (Dictyotales). Molecules. 2011; 16(10):8437-8450.

Chicago/Turabian Style

Mendes, Gabriella; Soares, Angélica Ribeiro; Sigiliano, Lorena; Machado, Fernanda; Kaiser, Carlos; Romeiro, Nelilma; Gestinari, Lísia; Santos, Norma; Romanos, Maria Teresa Villela. 2011. "In Vitro Anti-HMPV Activity of Meroditerpenoids from Marine Alga Stypopodium zonale (Dictyotales)." Molecules 16, no. 10: 8437-8450.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert