Antihyperlipidemic Properties of Novel N-(Benzoylphenyl)-5-substituted-1H-indole-2-carboxamides in Triton WR-1339-Induced Hyperlipidemic Rats
Abstract
:1. Introduction
2. Results and Discussion
2.1. Chemical Studies
2.2. Pharmacological Studies
2.2.1. Induction of Hyperlipidemia by Triton WR-1339
Lipid profile | TC (mg/dl) | TG (mg/dl) | HDL-C(mg/dl) | LDL-C (mg/dl) |
---|---|---|---|---|
NCG | 107 ± 0.76 | 131 ± 1.52 | 50.3 ± 0.40 | 31.1 ± 0.47 |
HG | 228 ± 3.32 b | 1526 ± 8.06 b | 30.6 ± 0.92 b | 61.6 ± 0.88 b |
C8 | 227 ± 3.53 | 1544 ± 3.38 | 28.0 ± 0.73 | 65.9 ± 0.50 |
C9 | 112 ± 1.09 a | 85 ± 1.60 b | 59.2 ± 0.88 b | 23.5 ± 0.53 a |
C15 | 220 ± 4.63 | 1566 ± 4.44 | 29.9 ± 0.33 | 63.6 ± 0.42 |
C16 | 109 ± 2.10 a | 96 ± 0.70 b | 61.0 ± 0.56 b | 24.9 ± 0.23 a |
C18 | 106 ± 0.99 a | 103 ± 2.43 b | 63.1 ± 0.31 b | 21.2 ± 0.31 a |
BF | 221 ± 2.40 | 132 ± 0.64 b | 48.5 ± 0.48 b | 60.9 ± 0.79 |
2.2.2. Effect of Compounds 8, 9, 15, 16, 18 and Bezafibrate on Rat Plasma Lipid Profile
3. Experimental
3.1. General
3.2. Animals and Treatments
3.3. Triton Model of Hyperlipidemia
3.4. Pharmacological Experimental Design
3.5. Statistical Analysis
Acknowledgements
- Sample Availability: Samples of the compounds are available from the authors.
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Al-Hiari, Y.; Shattat, G.; Al-Qirim, T.; El-Huneidi, W.; Sheikha, G.A.; Hikmat, S. Antihyperlipidemic Properties of Novel N-(Benzoylphenyl)-5-substituted-1H-indole-2-carboxamides in Triton WR-1339-Induced Hyperlipidemic Rats. Molecules 2011, 16, 8292-8304. https://doi.org/10.3390/molecules16108292
Al-Hiari Y, Shattat G, Al-Qirim T, El-Huneidi W, Sheikha GA, Hikmat S. Antihyperlipidemic Properties of Novel N-(Benzoylphenyl)-5-substituted-1H-indole-2-carboxamides in Triton WR-1339-Induced Hyperlipidemic Rats. Molecules. 2011; 16(10):8292-8304. https://doi.org/10.3390/molecules16108292
Chicago/Turabian StyleAl-Hiari, Yusuf, Ghassan Shattat, Tariq Al-Qirim, Waseem El-Huneidi, Ghassan Abu Sheikha, and Suhair Hikmat. 2011. "Antihyperlipidemic Properties of Novel N-(Benzoylphenyl)-5-substituted-1H-indole-2-carboxamides in Triton WR-1339-Induced Hyperlipidemic Rats" Molecules 16, no. 10: 8292-8304. https://doi.org/10.3390/molecules16108292