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Molecules 2011, 16(10), 8292-8304; doi:10.3390/molecules16108292
Article

Antihyperlipidemic Properties of Novel N-(Benzoylphenyl)-5-substituted-1H-indole-2-carboxamides in Triton WR-1339-Induced Hyperlipidemic Rats

1,* , 2, 2, 2, 2 and 2
1 Faculty of Pharmacy, University of Jordan, Amman-11942, Jordan 2 Faculty of Pharmacy, Al-Zaytoonah Private University, Amman-11733, Jordan
* Author to whom correspondence should be addressed.
Received: 19 July 2011 / Revised: 5 September 2011 / Accepted: 22 September 2011 / Published: 29 September 2011
(This article belongs to the Section Medicinal Chemistry)
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Abstract

In the search for new potential antihyperlipidemic agents, the present study focuses on the synthesis of novel N-(benzoylphenyl)-5-substituted-1H-indole-2-carboxamides (compounds 8-12, 15, 16, 18) and investigating their antihyperlipidemic activity using Triton WR-1339-induced hyperlipidemic rats as an experimental model. Hyperlipidemia was developed by intraperitoneal injection of Triton WR-1339 (250 mg/kg body weight). The tested animals were divided into normal control (NCG), hyperlipidemic (HG), compound 8, 9, 15, 16, 18- and bezafibrate treated groups. At a dose of 15 mg/kg body weight, compounds 9, 16, 18 and bezafibrate (100 mg/kg) significantly (p < 0.0001) reduced elevated plasma triglycerides levels after 12 h compared to the hyperlipidemic control group. However, only the group treated with compounds 9, 16 and 18 showed an obviously significant (p < 0.001) reduction in plasma total cholesterol levels after 12 h compared to the hyperlipidemic control group. Moreover, high density lipoprotein-cholesterol levels were significantly (p < 0.0001) increased in all treated groups after 12 h compared to the hyperlipidemic control group, except for compounds 8 and 15 which revealed inactive. It is therefore reasonable to assume that compounds 9, 16 and 18 may have potential in the treatment of hyperlipidemia.
Keywords: Triton WR-1339-induced hyperlipidemic rats; N-(benzoylphenyl)-5-methoxy-1H-indole-2-carboxamide; N-(Benzoylphenyl)-5-chloro-1H-indole-2-carboxamide; hypo-lipidemic activity Triton WR-1339-induced hyperlipidemic rats; N-(benzoylphenyl)-5-methoxy-1H-indole-2-carboxamide; N-(Benzoylphenyl)-5-chloro-1H-indole-2-carboxamide; hypo-lipidemic activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Al-Hiari, Y.; Shattat, G.; Al-Qirim, T.; El-Huneidi, W.; Sheikha, G.A.; Hikmat, S. Antihyperlipidemic Properties of Novel N-(Benzoylphenyl)-5-substituted-1H-indole-2-carboxamides in Triton WR-1339-Induced Hyperlipidemic Rats. Molecules 2011, 16, 8292-8304.

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