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Molecules 2011, 16(10), 8292-8304; doi:10.3390/molecules16108292
Article

Antihyperlipidemic Properties of Novel N-(Benzoylphenyl)-5-substituted-1H-indole-2-carboxamides in Triton WR-1339-Induced Hyperlipidemic Rats

1,* , 2, 2, 2, 2 and 2
Received: 19 July 2011; in revised form: 5 September 2011 / Accepted: 22 September 2011 / Published: 29 September 2011
(This article belongs to the Section Medicinal Chemistry)
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Abstract: In the search for new potential antihyperlipidemic agents, the present study focuses on the synthesis of novel N-(benzoylphenyl)-5-substituted-1H-indole-2-carboxamides (compounds 8-12, 15, 16, 18) and investigating their antihyperlipidemic activity using Triton WR-1339-induced hyperlipidemic rats as an experimental model. Hyperlipidemia was developed by intraperitoneal injection of Triton WR-1339 (250 mg/kg body weight). The tested animals were divided into normal control (NCG), hyperlipidemic (HG), compound 8, 9, 15, 16, 18- and bezafibrate treated groups. At a dose of 15 mg/kg body weight, compounds 9, 16, 18 and bezafibrate (100 mg/kg) significantly (p < 0.0001) reduced elevated plasma triglycerides levels after 12 h compared to the hyperlipidemic control group. However, only the group treated with compounds 9, 16 and 18 showed an obviously significant (p < 0.001) reduction in plasma total cholesterol levels after 12 h compared to the hyperlipidemic control group. Moreover, high density lipoprotein-cholesterol levels were significantly (p < 0.0001) increased in all treated groups after 12 h compared to the hyperlipidemic control group, except for compounds 8 and 15 which revealed inactive. It is therefore reasonable to assume that compounds 9, 16 and 18 may have potential in the treatment of hyperlipidemia.
Keywords: Triton WR-1339-induced hyperlipidemic rats; N-(benzoylphenyl)-5-methoxy-1H-indole-2-carboxamide; N-(Benzoylphenyl)-5-chloro-1H-indole-2-carboxamide; hypo-lipidemic activity Triton WR-1339-induced hyperlipidemic rats; N-(benzoylphenyl)-5-methoxy-1H-indole-2-carboxamide; N-(Benzoylphenyl)-5-chloro-1H-indole-2-carboxamide; hypo-lipidemic activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Al-Hiari, Y.; Shattat, G.; Al-Qirim, T.; El-Huneidi, W.; Sheikha, G.A.; Hikmat, S. Antihyperlipidemic Properties of Novel N-(Benzoylphenyl)-5-substituted-1H-indole-2-carboxamides in Triton WR-1339-Induced Hyperlipidemic Rats. Molecules 2011, 16, 8292-8304.

AMA Style

Al-Hiari Y, Shattat G, Al-Qirim T, El-Huneidi W, Sheikha GA, Hikmat S. Antihyperlipidemic Properties of Novel N-(Benzoylphenyl)-5-substituted-1H-indole-2-carboxamides in Triton WR-1339-Induced Hyperlipidemic Rats. Molecules. 2011; 16(10):8292-8304.

Chicago/Turabian Style

Al-Hiari, Yusuf; Shattat, Ghassan; Al-Qirim, Tariq; El-Huneidi, Waseem; Sheikha, Ghassan Abu; Hikmat, Suhair. 2011. "Antihyperlipidemic Properties of Novel N-(Benzoylphenyl)-5-substituted-1H-indole-2-carboxamides in Triton WR-1339-Induced Hyperlipidemic Rats." Molecules 16, no. 10: 8292-8304.



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