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Molecules 2011, 16(1), 175-189; doi:10.3390/molecules16010175

Design and Synthesis of Anti-MRSA Benzimidazolylbenzene-sulfonamides. QSAR Studies for Prediction of Antibacterial Activity

1,2,* , 3, 4, 5 and 2
1 Programa de Doctorado en Ciencias Biológicas, Universidad Autónoma Metropolitana, México D.F., Mexico 2 Facultad de Ciencias Químicas-CIEP, Universidad Autónoma de San Luis Potosí, San Luis Potosí, SLP, Mexico 3 Departamento de Química, División de Ciencias Básicas e Ingeniería, Universidad Autónoma Metropolitana, Unidad Iztapalapa, México D.F., Mexico 4 Instituto de Química, Universidad Nacional Autónoma de México, México D. F, Mexico 5 Departamento de Sistemas Biológicos, Universidad Autónoma Metropolitana, Unidad Xochimilco, México D. F., Mexico
* Author to whom correspondence should be addressed.
Received: 22 November 2010 / Revised: 24 December 2010 / Accepted: 28 December 2010 / Published: 29 December 2010
(This article belongs to the Special Issue Prodrugs)
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A series of benzimidazolylbenzenesulfonamide compounds containing electron-releasing and electron-withdrawing substituents were synthesized and tested for their in vitro antibacterial activity. Two BZS compounds showed strong antibacterial activity against methicillin-resistant Staphylococcus aureus and Bacillus subtilis. Quantitative studies of their structure-activity relationship using a simple linear regression analysis were applied to explore the correlation between the biological activity and the charges on acidic hydrogen atoms in the synthesized compounds.
Keywords: benzimidazole; sulphonamide; MRSA; antibacterial activity benzimidazole; sulphonamide; MRSA; antibacterial activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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González-Chávez, M.M.; Méndez, F.; Martínez, R.; Pérez-González, C.; Martínez-Gutiérrez, F. Design and Synthesis of Anti-MRSA Benzimidazolylbenzene-sulfonamides. QSAR Studies for Prediction of Antibacterial Activity. Molecules 2011, 16, 175-189.

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