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Molecules 2011, 16(1), 175-189; doi:10.3390/molecules16010175
Article

Design and Synthesis of Anti-MRSA Benzimidazolylbenzene-sulfonamides. QSAR Studies for Prediction of Antibacterial Activity

1,2,* , 3, 4, 5 and 2
1 Programa de Doctorado en Ciencias Biológicas, Universidad Autónoma Metropolitana, México D.F., Mexico 2 Facultad de Ciencias Químicas-CIEP, Universidad Autónoma de San Luis Potosí, San Luis Potosí, SLP, Mexico 3 Departamento de Química, División de Ciencias Básicas e Ingeniería, Universidad Autónoma Metropolitana, Unidad Iztapalapa, México D.F., Mexico 4 Instituto de Química, Universidad Nacional Autónoma de México, México D. F, Mexico 5 Departamento de Sistemas Biológicos, Universidad Autónoma Metropolitana, Unidad Xochimilco, México D. F., Mexico
* Author to whom correspondence should be addressed.
Received: 22 November 2010 / Revised: 24 December 2010 / Accepted: 28 December 2010 / Published: 29 December 2010
(This article belongs to the collection Prodrugs)
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Abstract

A series of benzimidazolylbenzenesulfonamide compounds containing electron-releasing and electron-withdrawing substituents were synthesized and tested for their in vitro antibacterial activity. Two BZS compounds showed strong antibacterial activity against methicillin-resistant Staphylococcus aureus and Bacillus subtilis. Quantitative studies of their structure-activity relationship using a simple linear regression analysis were applied to explore the correlation between the biological activity and the charges on acidic hydrogen atoms in the synthesized compounds.
Keywords: benzimidazole; sulphonamide; MRSA; antibacterial activity benzimidazole; sulphonamide; MRSA; antibacterial activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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González-Chávez, M.M.; Méndez, F.; Martínez, R.; Pérez-González, C.; Martínez-Gutiérrez, F. Design and Synthesis of Anti-MRSA Benzimidazolylbenzene-sulfonamides. QSAR Studies for Prediction of Antibacterial Activity. Molecules 2011, 16, 175-189.

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