Molecules 2011, 16(1), 175-189; doi:10.3390/molecules16010175
Article

Design and Synthesis of Anti-MRSA Benzimidazolylbenzene-sulfonamides. QSAR Studies for Prediction of Antibacterial Activity

1,2,* email, 3, 4, 5 and 2
Received: 22 November 2010; in revised form: 24 December 2010 / Accepted: 28 December 2010 / Published: 29 December 2010
(This article belongs to the collection Prodrugs)
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Abstract: A series of benzimidazolylbenzenesulfonamide compounds containing electron-releasing and electron-withdrawing substituents were synthesized and tested for their in vitro antibacterial activity. Two BZS compounds showed strong antibacterial activity against methicillin-resistant Staphylococcus aureus and Bacillus subtilis. Quantitative studies of their structure-activity relationship using a simple linear regression analysis were applied to explore the correlation between the biological activity and the charges on acidic hydrogen atoms in the synthesized compounds.
Keywords: benzimidazole; sulphonamide; MRSA; antibacterial activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

González-Chávez, M.M.; Méndez, F.; Martínez, R.; Pérez-González, C.; Martínez-Gutiérrez, F. Design and Synthesis of Anti-MRSA Benzimidazolylbenzene-sulfonamides. QSAR Studies for Prediction of Antibacterial Activity. Molecules 2011, 16, 175-189.

AMA Style

González-Chávez MM, Méndez F, Martínez R, Pérez-González C, Martínez-Gutiérrez F. Design and Synthesis of Anti-MRSA Benzimidazolylbenzene-sulfonamides. QSAR Studies for Prediction of Antibacterial Activity. Molecules. 2011; 16(1):175-189.

Chicago/Turabian Style

González-Chávez, Marco Martín; Méndez, Francisco; Martínez, Roberto; Pérez-González, Cuaúhtemoc; Martínez-Gutiérrez, Fidel. 2011. "Design and Synthesis of Anti-MRSA Benzimidazolylbenzene-sulfonamides. QSAR Studies for Prediction of Antibacterial Activity." Molecules 16, no. 1: 175-189.


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