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Molecules 2011, 16(1), 190-201; doi:10.3390/molecules16010190
Article

Casbane Diterpene as a Promising Natural Antimicrobial Agent against Biofilm-Associated Infections

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1 Department of Biochemistry and Molecular Biology, Faculty of Medicine of Sobral, Federal University of Ceará, Fortaleza, CE, Brazil 2 Centre of the Exact Sciences and Technology, Acaraú Valley State University, 62040-370, Sobral, CE, Brazil 3 Northeast Biotechnology Network (RENORBIO), State University of Ceará, 60740-000, Fortaleza, CE, Brazil 4 Centre for Biological Engineering, IBB-Institute for Biotechnology and Bioengineering, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal
* Author to whom correspondence should be addressed.
Received: 17 November 2010 / Revised: 29 November 2010 / Accepted: 20 December 2010 / Published: 30 December 2010
(This article belongs to the Section Metabolites)
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Abstract

Croton nepetaefolius is a native plant from northeastern Brazil that belongs to the Euphorbiaceae family. The biological action of this plant has been extensively explored, being the secondary metabolites responsible for its properties alkaloids, diterpenes, and triterpenes. This study aimed to evaluate the ability of casbane diterpene (CD), isolated from the ethanolic extract of C. nepetaefolius, to inhibit microbial growth and biofilm formation of several clinical relevant species (bacteria and yeasts). It was found that CD possessed biocidal and biostatic activity against the majority of the species screened, with minimal active concentrations ranging between 125 and 500 µg/mL. In addition, it was observed that biofilm formation was inhibited even when the planktonic growth was not significantly affected. In conclusion, CD showed potential to be a natural tool for the treatment of diseases caused by different infectious microorganisms.
Keywords: casbane diterpene; biofilm-associated infections control; natural antimicrobials; bacteria and yeast casbane diterpene; biofilm-associated infections control; natural antimicrobials; bacteria and yeast
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Carneiro, V.A.; Santos, H.S.; Arruda, F.V.S.; Bandeira, P.N.; Albuquerque, M.R.J.R.; Pereira, M.O.; Henriques, M.; Cavada, B.S.; Teixeira, E.H. Casbane Diterpene as a Promising Natural Antimicrobial Agent against Biofilm-Associated Infections. Molecules 2011, 16, 190-201.

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