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Casbane Diterpene as a Promising Natural Antimicrobial Agent against Biofilm-Associated Infections
Department of Biochemistry and Molecular Biology, Faculty of Medicine of Sobral, Federal University of Ceará, Fortaleza, CE, Brazil
Centre of the Exact Sciences and Technology, Acaraú Valley State University, 62040-370, Sobral, CE, Brazil
Northeast Biotechnology Network (RENORBIO), State University of Ceará, 60740-000, Fortaleza, CE, Brazil
Centre for Biological Engineering, IBB-Institute for Biotechnology and Bioengineering, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal
* Author to whom correspondence should be addressed.
Received: 17 November 2010; in revised form: 29 November 2010 / Accepted: 20 December 2010 / Published: 30 December 2010
Abstract: Croton nepetaefolius is a native plant from northeastern Brazil that belongs to the Euphorbiaceae family. The biological action of this plant has been extensively explored, being the secondary metabolites responsible for its properties alkaloids, diterpenes, and triterpenes. This study aimed to evaluate the ability of casbane diterpene (CD), isolated from the ethanolic extract of C. nepetaefolius, to inhibit microbial growth and biofilm formation of several clinical relevant species (bacteria and yeasts). It was found that CD possessed biocidal and biostatic activity against the majority of the species screened, with minimal active concentrations ranging between 125 and 500 µg/mL. In addition, it was observed that biofilm formation was inhibited even when the planktonic growth was not significantly affected. In conclusion, CD showed potential to be a natural tool for the treatment of diseases caused by different infectious microorganisms.
Keywords: casbane diterpene; biofilm-associated infections control; natural antimicrobials; bacteria and yeast
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Carneiro, V.A.; Santos, H.S.; Arruda, F.V.S.; Bandeira, P.N.; Albuquerque, M.R.J.R.; Pereira, M.O.; Henriques, M.; Cavada, B.S.; Teixeira, E.H. Casbane Diterpene as a Promising Natural Antimicrobial Agent against Biofilm-Associated Infections. Molecules 2011, 16, 190-201.
Carneiro VA, Santos HS, Arruda FVS, Bandeira PN, Albuquerque MRJR, Pereira MO, Henriques M, Cavada BS, Teixeira EH. Casbane Diterpene as a Promising Natural Antimicrobial Agent against Biofilm-Associated Infections. Molecules. 2011; 16(1):190-201.
Carneiro, Victor Alves; Santos, Hélcio Silva dos; Arruda, Francisco Vassiliepe Sousa; Bandeira, Paulo Nogueira; Albuquerque, Maria Rose Jane Ribeiro; Pereira, Maria Olívia; Henriques, Mariana; Cavada, Benildo Sousa; Teixeira, Edson Holanda. 2011. "Casbane Diterpene as a Promising Natural Antimicrobial Agent against Biofilm-Associated Infections." Molecules 16, no. 1: 190-201.