Next Article in Journal
Development of Heterogeneous Olympic Medal Metal Nanoparticle Catalysts for Environmentally Benign Molecular Transformations Based on the Surface Properties of Hydrotalcite
Previous Article in Journal
Acanmontanoside, a New Phenylethanoid Diglycoside from Acanthus montanus
Previous Article in Special Issue
Bisbenzamidines as Antifungal Agents. Are Both Amidine Functions Required to Observe an Anti-Pneumocystis carinii Activity?
Molecules 2010, 15(12), 8973-8987; doi:10.3390/molecules15128973
Article

Preparation and Properties of New Co-Crystals of Ibandronate with Gluco- or Galactopyranoside Derivatives

1,2, 3, 1,3, 3, 1, 1, 1, 1, 1, 1,3 and 1,3,*
Received: 22 November 2010; in revised form: 3 December 2010 / Accepted: 7 December 2010 / Published: 8 December 2010
(This article belongs to the Special Issue ECSOC-13)
Download PDF [412 KB, uploaded 18 June 2014]
Abstract: Mixtures of ibandronate monosodium salt with eleven gluco- and/or galacto-pyranoside derivatives as counterions were designed to prepare co-crystals with improved intestinal absorption. In general, gastrointestinal absorption of bisphosphonates after oral administration is approximately 1%. Co-crystals were generated by means of thermodynamically and/or kinetically controlled crystallization processes. Seventy-seven prepared samples were analyzed by means of FT-NIR, FT-Raman spectrometry and solid state NMR spectroscopy. New entities of ibandronate monosodium salt with phenyl-β-d-galactopyranoside were found and characterized. The absorption of these potential new co-crystals was investigated by means of PAMPA experiments. In the present study the relationships between the chemical structures of the studied compounds required for co-crystal generation are discussed.
Keywords: ibandronate; d-glucopyranosides; d-galactopyranosides; co-crystals; FT-NIR; FT-Raman; CP/MAS NMR; PAMPA ibandronate; d-glucopyranosides; d-galactopyranosides; co-crystals; FT-NIR; FT-Raman; CP/MAS NMR; PAMPA
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Oktabec, Z.; Kos, J.; Mandelova, Z.; Havelkova, L.; Pekarek, T.; Rezacova, A.; Placek, L.; Tkadlecova, M.; Havlicek, J.; Dohnal, J.; Jampílek, J. Preparation and Properties of New Co-Crystals of Ibandronate with Gluco- or Galactopyranoside Derivatives. Molecules 2010, 15, 8973-8987.

AMA Style

Oktabec Z, Kos J, Mandelova Z, Havelkova L, Pekarek T, Rezacova A, Placek L, Tkadlecova M, Havlicek J, Dohnal J, Jampílek J. Preparation and Properties of New Co-Crystals of Ibandronate with Gluco- or Galactopyranoside Derivatives. Molecules. 2010; 15(12):8973-8987.

Chicago/Turabian Style

Oktabec, Zbynek; Kos, Jiri; Mandelova, Zuzana; Havelkova, Lenka; Pekarek, Tomas; Rezacova, Anna; Placek, Lukas; Tkadlecova, Marcela; Havlicek, Jaroslav; Dohnal, Jiri; Jampílek, Josef. 2010. "Preparation and Properties of New Co-Crystals of Ibandronate with Gluco- or Galactopyranoside Derivatives." Molecules 15, no. 12: 8973-8987.


Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert