Molecules 2010, 15(6), 4129-4188; doi:10.3390/molecules15064129
Review

Conazoles

Jan Heeres 1 email, Lieven Meerpoel 2,* email and Paul Lewi 3 email
1 Leemskuilen 18, B-2350 Vosselaar, Belgium 2 Johnson & Johnson Pharmaceutical Research & Development, a division of Janssen Pharmaceutica N.V.,Turnhoutseweg 30, B-2340 Beerse, Belgium 3 Pater Van Mierlostraat 18, B-2300 Turnhout, Belgium
* Author to whom correspondence should be addressed.
Received: 4 May 2010 / Accepted: 7 June 2010 / Published: 9 June 2010
(This article belongs to the Special Issue Anti-Infective Agents)
PDF Full-text Download PDF Full-Text [510 KB, uploaded 9 June 2010 11:09 CEST]
Abstract: This review provides a historical overview of the analog based drug discovery of miconazole and its congeners, and is focused on marketed azole antifungals bearing the generic suffix “conazole”. The antifungal activity of miconazole, one of the first broad-spectrum antimycotic agents has been mainly restricted to topical applications. The attractive in vitro antifungal spectrum was a starting point to design more potent and especially orally active antifungal agents such as ketoconazole, itraconazole, posaconazole, fluconazole and voriconazole. The chemistry, in vitro and in vivo antifungal activity, pharmacology, and clinical applications of these marketed conazoles has been described.
Keywords: miconazole; ketoconazole; itraconazole; posaconazole; fluconazole; voriconazole; antifungal

Article Statistics

Click here to load and display the download statistics.

Cite This Article

MDPI and ACS Style

Heeres, J.; Meerpoel, L.; Lewi, P. Conazoles. Molecules 2010, 15, 4129-4188.

AMA Style

Heeres J, Meerpoel L, Lewi P. Conazoles. Molecules. 2010; 15(6):4129-4188.

Chicago/Turabian Style

Heeres, Jan; Meerpoel, Lieven; Lewi, Paul. 2010. "Conazoles." Molecules 15, no. 6: 4129-4188.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert