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Molecules 2010, 15(6), 4129-4188; doi:10.3390/molecules15064129
Review

Conazoles

1
,
2,*  and 3
Received: 4 May 2010 / Accepted: 7 June 2010 / Published: 9 June 2010
(This article belongs to the Special Issue Anti-Infective Agents)
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Abstract

This review provides a historical overview of the analog based drug discovery of miconazole and its congeners, and is focused on marketed azole antifungals bearing the generic suffix “conazole”. The antifungal activity of miconazole, one of the first broad-spectrum antimycotic agents has been mainly restricted to topical applications. The attractive in vitro antifungal spectrum was a starting point to design more potent and especially orally active antifungal agents such as ketoconazole, itraconazole, posaconazole, fluconazole and voriconazole. The chemistry, in vitro and in vivo antifungal activity, pharmacology, and clinical applications of these marketed conazoles has been described.
Keywords: miconazole; ketoconazole; itraconazole; posaconazole; fluconazole; voriconazole; antifungal miconazole; ketoconazole; itraconazole; posaconazole; fluconazole; voriconazole; antifungal
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Heeres, J.; Meerpoel, L.; Lewi, P. Conazoles. Molecules 2010, 15, 4129-4188.

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