Molecules 2010, 15(9), 5878-5908; doi:10.3390/molecules15095878
Review

Discovery and Development of Anti-HBV Agents and Their Resistance

Received: 4 August 2010; in revised form: 24 August 2010 / Accepted: 26 August 2010 / Published: 27 August 2010
(This article belongs to the Special Issue Anti-Infective Agents)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Hepatitis B virus (HBV) infection is a prime cause of liver diseases such as hepatitis, cirrhosis and hepatocellular carcinoma. The current drugs clinically available are nucleot(s)ide analogues that inhibit viral reverse transcriptase activity. Most drugs of this class are reported to have viral resistance with breakthrough. Recent advances in methods for in silico virtual screening of chemical libraries, together with a better understanding of the resistance mechanisms of existing drugs have expedited the discovery and development of novel anti-viral drugs. This review summarizes the current status of knowledge about and viral resistance of HBV drugs, approaches for the development of novel drugs as well as new viral and host targets for future drugs.
Keywords: hepatitis B virus; antiviral agent; drug development; drug resistance; modeling; rational drug design
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MDPI and ACS Style

Kim, K.-H.; Kim, N.D.; Seong, B.-L. Discovery and Development of Anti-HBV Agents and Their Resistance. Molecules 2010, 15, 5878-5908.

AMA Style

Kim K-H, Kim ND, Seong B-L. Discovery and Development of Anti-HBV Agents and Their Resistance. Molecules. 2010; 15(9):5878-5908.

Chicago/Turabian Style

Kim, Kyun-Hwan; Kim, Nam Doo; Seong, Baik-Lin. 2010. "Discovery and Development of Anti-HBV Agents and Their Resistance." Molecules 15, no. 9: 5878-5908.

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