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Discovery and Development of Anti-HBV Agents and Their Resistance
Department of Pharmacology, School of Medicine, and Center for Cancer Research and Diagnostic Medicine, IBST, Konkuk University, Seoul 143-701, Korea
Research Institute of Medical Sciences, Konkuk University, Seoul 143-701, Korea
R&D Center, Equispharm Inc., 11F Gyeonggi Bio-Center, 864-1 Iui-Dong, Yeongtong-gu, Suwon-Shi, Gyeonggi-Do 443-766, Korea
Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 120-749, Korea
Translational Research Center for Protein Function Control, Yonsei University, Seoul 120-749, Korea
* Authors to whom correspondence should be addressed.
Received: 4 August 2010; in revised form: 24 August 2010 / Accepted: 26 August 2010 / Published: 27 August 2010
Abstract: Hepatitis B virus (HBV) infection is a prime cause of liver diseases such as hepatitis, cirrhosis and hepatocellular carcinoma. The current drugs clinically available are nucleot(s)ide analogues that inhibit viral reverse transcriptase activity. Most drugs of this class are reported to have viral resistance with breakthrough. Recent advances in methods for in silico virtual screening of chemical libraries, together with a better understanding of the resistance mechanisms of existing drugs have expedited the discovery and development of novel anti-viral drugs. This review summarizes the current status of knowledge about and viral resistance of HBV drugs, approaches for the development of novel drugs as well as new viral and host targets for future drugs.
Keywords: hepatitis B virus; antiviral agent; drug development; drug resistance; modeling; rational drug design
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Kim, K.-H.; Kim, N.D.; Seong, B.-L. Discovery and Development of Anti-HBV Agents and Their Resistance. Molecules 2010, 15, 5878-5908.
Kim K-H, Kim ND, Seong B-L. Discovery and Development of Anti-HBV Agents and Their Resistance. Molecules. 2010; 15(9):5878-5908.
Kim, Kyun-Hwan; Kim, Nam Doo; Seong, Baik-Lin. 2010. "Discovery and Development of Anti-HBV Agents and Their Resistance." Molecules 15, no. 9: 5878-5908.