Next Article in Journal
Processing of Polymer Nanocomposites Reinforced with Polysaccharide Nanocrystals
Previous Article in Journal
An Expeditious Synthesis of [1,2]Isoxazolidin-5-ones and [1,2]Oxazin-6-ones from Functional Allyl Bromide Derivatives
Article Menu

Article Versions

Export Article

Open AccessArticle
Molecules 2010, 15(6), 4102-4110; doi:10.3390/molecules15064102

Synthesis of a New Series of N,N’-Dimethyltetrahydrosalen (H2 [H2Me]salen) Ligands by the Reductive Ring-Opening of 3,3'-Ethylene-bis(3,4-dihydro-6-substituted-2H-1,3-benzoxazines)

Departamento de Química, Universidad Nacional de Colombia, Bogotá, Colombia, A.A. 14490, Colombia
Author to whom correspondence should be addressed.
Received: 26 April 2010 / Revised: 7 May 2010 / Accepted: 11 May 2010 / Published: 7 June 2010
Download PDF [104 KB, uploaded 18 June 2014]


A new series of N,N'-bis(2'-hydroxy-5'-substituted-benzyl)-N,N´-dimethylethane-1,2-diamines (N,N'-dimethyltetrahydrosalen) ligands were prepared in good yield by reduction of the respective 3,3'-ethylene-bis(3,4-dihydro-6-substituted-2H-1,3-benzoxazine) precursors with sodium borohydride . The ligands were characterized by IR, NMR, and elemental analysis, which showed the compounds to be consistent with the proposed structures. Ring-opening reactions of bis-1,3-benzoxazines in the presence of sodium borohydride to produce N,N’-dimethylated tetrahydrosalens (H2 [H2Me]salen) have not been reported in the literature.
Keywords: tetrahydrosalen; salan; bis-benzoxazines; tetradentate ligand tetrahydrosalen; salan; bis-benzoxazines; tetradentate ligand
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Rivera, A.; Rojas, J.J.; Salazar-Barrios, J.; Maldonado, M.; Ríos-Motta, J. Synthesis of a New Series of N,N’-Dimethyltetrahydrosalen (H2 [H2Me]salen) Ligands by the Reductive Ring-Opening of 3,3'-Ethylene-bis(3,4-dihydro-6-substituted-2H-1,3-benzoxazines). Molecules 2010, 15, 4102-4110.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top