Next Article in Journal
Design, Synthesis and Structure-activity Studies of Rhodanine Derivatives as HIV-1 Integrase Inhibitors
Previous Article in Journal
Antifungal Activity and Nail Permeation of Nail Lacquer Containing Piper regnellii (Miq.) C. CD. var. pallescens (C. DC.) Yunck (Piperaceae) Leave Extracts and Derivatives
Molecules 2010, 15(6), 3932-3957; doi:10.3390/molecules15063932
Article

Synthesis, Characterization and Biological Studies of Some Novel Thieno[2,3-d]pyrimidines

1,* , 2 and 1
1 Chemistry Department, College of Science, King Faisal University, P.O. Box 400, Hofuf 31982, Saudi Arabia 2 Chemistry Department, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia
* Author to whom correspondence should be addressed.
Received: 29 March 2010 / Revised: 20 May 2010 / Accepted: 27 May 2010 / Published: 1 June 2010
Download PDF [348 KB, uploaded 18 June 2014]

Abstract

Several 2-unsubstituted thieno[2,3-d]pyrimidines have been prepared from 2-aminothiophene-3-carboxylic acid esters and their carbonitrile analogs. Some triazolo-thienopyrimidine and 2-thioxothienopyrimidine representatives have also been synthesized using thermal and microwave (MW) irradiation techniques. Structures of the prepared compounds were elucidated on the basis of IR, NMR, 2D NMR and mass spectral data. The biological activity of some selected synthesized compounds was also examined.
Keywords: thienopyridines; triazolothienopyrimidines; antibacterial activity; cytotoxic activity thienopyridines; triazolothienopyrimidines; antibacterial activity; cytotoxic activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Export to BibTeX |
EndNote


MDPI and ACS Style

Al-Taisan, K.M.; Al-Hazimi, H.M.A.; Al-Shihry, S.S. Synthesis, Characterization and Biological Studies of Some Novel Thieno[2,3-d]pyrimidines. Molecules 2010, 15, 3932-3957.

View more citation formats

Related Articles

Article Metrics

Comments

Citing Articles

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert