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Molecules 2010, 15(6), 3932-3957; doi:10.3390/molecules15063932
Article

Synthesis, Characterization and Biological Studies of Some Novel Thieno[2,3-d]pyrimidines

1,* , 2 and 1
Received: 29 March 2010 / Revised: 20 May 2010 / Accepted: 27 May 2010 / Published: 1 June 2010
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Abstract

Several 2-unsubstituted thieno[2,3-d]pyrimidines have been prepared from 2-aminothiophene-3-carboxylic acid esters and their carbonitrile analogs. Some triazolo-thienopyrimidine and 2-thioxothienopyrimidine representatives have also been synthesized using thermal and microwave (MW) irradiation techniques. Structures of the prepared compounds were elucidated on the basis of IR, NMR, 2D NMR and mass spectral data. The biological activity of some selected synthesized compounds was also examined.
Keywords: thienopyridines; triazolothienopyrimidines; antibacterial activity; cytotoxic activity thienopyridines; triazolothienopyrimidines; antibacterial activity; cytotoxic activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Al-Taisan, K.M.; Al-Hazimi, H.M.A.; Al-Shihry, S.S. Synthesis, Characterization and Biological Studies of Some Novel Thieno[2,3-d]pyrimidines. Molecules 2010, 15, 3932-3957.

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