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Molecules 2010, 15(6), 3887-3904; doi:10.3390/molecules15063887

Synthesis and Adrenolytic Activity of New Propanolamines

1,* , 1, 1, 1, 2, 3 and 2,*
1 Faculty of Chemistry, Rzeszów University of Technology, 6 Powstańców Warszawy Avenue, 35-959 Rzeszów, Poland 2 Laboratory of Pharmacological Screening, Jagiellonian University Medical College, 9 Medyczna, 30-689 Kraków, Poland 3 Department of Pharmacobiology, Jagiellonian University Medical College, 9 Medyczna, 30-689 Kraków, Poland
* Authors to whom correspondence should be addressed.
Received: 20 April 2010 / Revised: 23 May 2010 / Accepted: 26 May 2010 / Published: 28 May 2010
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The synthesis of (2R,S)-1-(6-methoxy-4-(methoxymethyl)-1H-indol-5-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol and (2R,S)-1-(4-methoxy-6-(methoxymethyl)-1H-indol-5-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol is described. The compounds were tested for electrographic, antiarrhythmic, hypotensive, and spasmolytic activity, as well as for a1-, a2- and β1-adrenoceptor binding affinity.
Keywords: α1-andrenoceptor antagonist; synthesis; pharmacology α1-andrenoceptor antagonist; synthesis; pharmacology
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Groszek, G.; Bajek, A.; Bis, A.; Nowak-Król, A.; Bednarski, M.; Siwek, A.; Filipek, B. Synthesis and Adrenolytic Activity of New Propanolamines. Molecules 2010, 15, 3887-3904.

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