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Molecules 2010, 15(6), 3887-3904; doi:10.3390/molecules15063887

Synthesis and Adrenolytic Activity of New Propanolamines

Faculty of Chemistry, Rzeszów University of Technology, 6 Powstańców Warszawy Avenue, 35-959 Rzeszów, Poland
Laboratory of Pharmacological Screening, Jagiellonian University Medical College, 9 Medyczna, 30-689 Kraków, Poland
Department of Pharmacobiology, Jagiellonian University Medical College, 9 Medyczna, 30-689 Kraków, Poland
Authors to whom correspondence should be addressed.
Received: 20 April 2010 / Revised: 23 May 2010 / Accepted: 26 May 2010 / Published: 28 May 2010
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The synthesis of (2R,S)-1-(6-methoxy-4-(methoxymethyl)-1H-indol-5-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol and (2R,S)-1-(4-methoxy-6-(methoxymethyl)-1H-indol-5-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol is described. The compounds were tested for electrographic, antiarrhythmic, hypotensive, and spasmolytic activity, as well as for a1-, a2- and β1-adrenoceptor binding affinity.
Keywords: α1-andrenoceptor antagonist; synthesis; pharmacology α1-andrenoceptor antagonist; synthesis; pharmacology

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Groszek, G.; Bajek, A.; Bis, A.; Nowak-Król, A.; Bednarski, M.; Siwek, A.; Filipek, B. Synthesis and Adrenolytic Activity of New Propanolamines. Molecules 2010, 15, 3887-3904.

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