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• Groszek, G
• Bajek, A
• Bis, A
• Nowak-Król, A
• Bednarski, M
• Siwek, A
• Filipek, B
• [+] on Google Scholar
• Groszek, G
• Bajek, A
• Bis, A
• Nowak-Król, A
• Bednarski, M
• Siwek, A
• Filipek, B
• [+] on PubMed
• Groszek, G
• Bajek, A
• Bis, A
• Nowak-Król, A
• Bednarski, M
• Siwek, A
• Filipek, B

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Molecules 2010, 15(6), 3887-3904; doi:10.3390/molecules15063887

Article

Synthesis and Adrenolytic Activity of New Propanolamines

Grażyna Groszek ^1,* , Agata Bajek ¹ , Agnieszka Bis ¹ , Agnieszka Nowak-Król ¹ , Marek Bednarski ² , Agata Siwek ³  and Barbara Filipek ^2,*

¹ Faculty of Chemistry, Rzeszów University of Technology, 6 Powstańców Warszawy Avenue, 35-959 Rzeszów, Poland ² Laboratory of Pharmacological Screening, Jagiellonian University Medical College, 9 Medyczna, 30-689 Kraków, Poland ³ Department of Pharmacobiology, Jagiellonian University Medical College, 9 Medyczna, 30-689 Kraków, Poland

* Authors to whom correspondence should be addressed.

Received: 20 April 2010; in revised form: 23 May 2010 / Accepted: 26 May 2010 / Published: 28 May 2010

Download PDF Full-Text [286 KB, uploaded 28 May 2010 15:33 CEST]

Abstract: The synthesis of (2R,S)-1-(6-methoxy-4-(methoxymethyl)-1H-indol-5-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol and (2R,S)-1-(4-methoxy-6-(methoxymethyl)-1H-indol-5-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol is described. The compounds were tested for electrographic, antiarrhythmic, hypotensive, and spasmolytic activity, as well as for a₁-, a₂- and β₁-adrenoceptor binding affinity.

Keywords: α1-andrenoceptor antagonist; synthesis; pharmacology

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