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Molecules 2010, 15(6), 3887-3904; doi:10.3390/molecules15063887
Article

Synthesis and Adrenolytic Activity of New Propanolamines

1,* , 1, 1, 1, 2, 3 and 2,*
Received: 20 April 2010; in revised form: 23 May 2010 / Accepted: 26 May 2010 / Published: 28 May 2010
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Abstract: The synthesis of (2R,S)-1-(6-methoxy-4-(methoxymethyl)-1H-indol-5-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol and (2R,S)-1-(4-methoxy-6-(methoxymethyl)-1H-indol-5-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol is described. The compounds were tested for electrographic, antiarrhythmic, hypotensive, and spasmolytic activity, as well as for a1-, a2- and β1-adrenoceptor binding affinity.
Keywords: α1-andrenoceptor antagonist; synthesis; pharmacology α1-andrenoceptor antagonist; synthesis; pharmacology
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Groszek, G.; Bajek, A.; Bis, A.; Nowak-Król, A.; Bednarski, M.; Siwek, A.; Filipek, B. Synthesis and Adrenolytic Activity of New Propanolamines. Molecules 2010, 15, 3887-3904.

AMA Style

Groszek G, Bajek A, Bis A, Nowak-Król A, Bednarski M, Siwek A, Filipek B. Synthesis and Adrenolytic Activity of New Propanolamines. Molecules. 2010; 15(6):3887-3904.

Chicago/Turabian Style

Groszek, Grażyna; Bajek, Agata; Bis, Agnieszka; Nowak-Król, Agnieszka; Bednarski, Marek; Siwek, Agata; Filipek, Barbara. 2010. "Synthesis and Adrenolytic Activity of New Propanolamines." Molecules 15, no. 6: 3887-3904.



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