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Molecules 2010, 15(6), 3878-3886; doi:10.3390/molecules15063878
Communication

Anti-Proliferative Effect of Camellianin A in Adinandra nitida Leaves and Its Apoptotic Induction in Human Hep G2 and MCF-7 Cells

1
,
1,* , 2
 and
1
1 School of Food Science, Henan Institute of Science and Technology, Xinxiang 453003, China 2 The Key Laboratory of Chemical Biology, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China
* Author to whom correspondence should be addressed.
Received: 1 April 2010 / Revised: 14 May 2010 / Accepted: 24 May 2010 / Published: 28 May 2010
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Abstract

Leaves of Adinandra nitida constitute a kind of flavonoid-rich plant food. In this study, camellianin A, the main flavonoid in the leaves of Adinandra nitida,was prepared and identified by high performance liquid chromatography-photodiode array detector-electrospray ionization mass spectrometry (HPLC-PDA-ESI/MS). In the anticancer assay, it was found camellianin A could inhibit the proliferation of the human hepatocellular liver carcinoma Hep G2 and human breast adenocarcinoma MCF-7 cell lines in a dose-dependent manner and induce the significant increase of the G0/G1 cell population. After treated by camellianin A, phosphatidylserine of Hep G2 and MCF-7 cells could translocate significantly to the surface of the membrane. The increase of an early apoptotic population of Hep G2 and MCF-7 cells was observed. It was concluded that camellianin A not only affected the progress of the cell cycle, but also induced cells to enter into apoptosis.
Keywords: Adinandra nitida; camellianin A; flavonoid; apoptosis; cell cycle Adinandra nitida; camellianin A; flavonoid; apoptosis; cell cycle
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Gao, H.; Liu, B.; Liu, F.; Chen, Y. Anti-Proliferative Effect of Camellianin A in Adinandra nitida Leaves and Its Apoptotic Induction in Human Hep G2 and MCF-7 Cells. Molecules 2010, 15, 3878-3886.

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