Next Article in Journal
Antioxidant Activity of Polysaccharide-enriched Fractions Extracted from Pulp Tissue of Litchi Chinensis Sonn.
Next Article in Special Issue
Antioxidant Capacity of Macaronesian Traditional Medicinal Plants
Previous Article in Journal
Recent Advances in Noble Metal Nanocatalysts for Suzuki and Heck Cross-Coupling Reactions
Previous Article in Special Issue
Antioxidant Properties of Cap and Stipe from Coprinus comatus
Molecules 2010, 15(4), 2139-2151; doi:10.3390/molecules15042139

Assessment of Antioxidant Capacity and Cytotoxicity of Selected Malaysian Plants

1 and 4,*
1 Department of Physiology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia 2 Pathology Division, Faculty of Medicine and Health, International Medical University, Bukit Jalil, 57000, Kuala Lumpur, Malaysia 3 SIRIM Bhd, 1 Persiaran Dato Menteri, 40911, Shah Alam, Selangor Darul Ehsan, Malaysia 4 School of Medicine and Health Sciences, Monash University Sunway Campus, Jalan Lagoon Selatan, 46150, Bandar Sunway, Malaysia
* Author to whom correspondence should be addressed.
Received: 22 December 2009 / Revised: 12 February 2010 / Accepted: 3 March 2010 / Published: 25 March 2010
(This article belongs to the Special Issue Antioxidants)
Download PDF [206 KB, 18 June 2014; original version 18 June 2014]


Thirteen Malaysian plants; Artocarpus champeden, Azadirachta indica, Fragaria x ananassa, Garcinia mangostana, Lawsonia inermis, Mangifera indica, Nephelium lappaceum, Nephelium mutobile, Peltophorum pterocarpum, Psidium guajava and Syzygium aqueum, selected for their use in traditional medicine, were subjected to a variety of assays. Antioxidant capability, total phenolic content, elemental composition, as well as it cytotoxity to several cell lines of the aqueous and ethanolic extracts from different parts of these selected Malaysian plants were determined. In general, the ethanolic extracts were better free radical scavengers than the aqueous extracts and some of the tested extracts were even more potent than a commercial grape seed preparation. Similar results were seen in the lipid peroxidation inhibition studies. Our findings also showed a strong correlation of antioxidant activity with the total phenolic content. These extracts when tested for its heavy metals content, were found to be below permissible value for nutraceutical application. In addition, most of the extracts were found not cytotoxic to 3T3 and 4T1 cells at concentrations as high as 100 μg/mL. We conclude that although traditionally these plants are used in the aqueous form, its commercial preparation could be achieved using ethanol since a high total phenolic content and antioxidant activity is associated with this method of preparation.
Keywords: free radical scavenging; lipid peroxidation; cytotoxicity; total phenolic content; elemental analysis; Malaysian plants free radical scavenging; lipid peroxidation; cytotoxicity; total phenolic content; elemental analysis; Malaysian plants
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
MDPI and ACS Style

Ling, L.T.; Radhakrishnan, A.K.; Subramaniam, T.; Cheng, H.M.; Palanisamy, U.D. Assessment of Antioxidant Capacity and Cytotoxicity of Selected Malaysian Plants. Molecules 2010, 15, 2139-2151.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


Cited By

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert