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Antioxidant Capacity of Macaronesian Traditional Medicinal Plants
Disease & Stress Biology, Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, 2781-901 Oeiras, Portugal
Nutraceuticals and Delivery Laboratory, Instituto de Tecnologia Química e Biológica/ IBET, Universidade Nova de Lisboa, 2781-901 Oeiras, Portugal
REQUIMTE, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal
Analytical Chemistry Laboratory, Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, 2781-901 Oeiras, Portugal
Faculdade de Farmácia da Universidade de Lisboa, Av. Prof. Gama Pinto,1649-003 Lisboa, Portugal
Analytical Laboratory, Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa, 2781-901 Oeiras, Portugal
Instituto Superior de Agronomia, Centro de Botânica Aplicada à Agricultura, Universidade Técnica de Lisboa, Tapada da Ajuda, 1349-017 Lisboa, Portugal
* Author to whom correspondence should be addressed.
Received: 9 February 2010; in revised form: 30 March 2010 / Accepted: 6 April 2010 / Published: 12 April 2010
Abstract: The use of many traditional medicinal plants is often hampered by the absence of a proper biochemical characterization, essential to identify the bioactive compounds present. The leaves from five species endemic to the Macaronesian islands with recognized ethnobotanical applications were analysed: Apollonias barbujana (Cav.) Bornm., Ocotea foetens (Ainton) Baill, Prunus azorica (Mouill.) Rivas-Mart., Lousã, Fern. Prieto, E. Días, J.C. Costa & C. Aguiar, Rumex maderensis Lowe and Plantago arborescens Poir. subsp. maderensis (Dcne.) A. Hans. et Kunk.. Since oxidative stress is a common feature of most diseases traditionally treated by these plants, it is important to assess their antioxidant capacity and determine the molecules responsible for this capacity. In this study, the antioxidant capacity of these plants against two of the most important reactive species in human body (hydroxyl and peroxyl radicals) was determined. To trace the antioxidant origin total phenol and flavonoid contents as well as the polyphenolic profile and the amount of trace elements were determined. There was a wide variation among the species analysed in what concerns their total leaf phenol and flavonoid contents. From the High Performance Liquid Chromatography (HPLC) electrochemically detected peaks it was possible to attribute to flavonoids the antioxidant capacity detected in A. barbujana, O. foetens, R. maderensis and P. azorica extracts. These potential reactive flavonoids were identified for A. barbujana, R. maderensis and P. azorica. For R. maderensis a high content (7 mg g-1 dry weight) of L-ascorbic acid, an already described antioxidant phytomolecule, was found. A high content in selenomethionine (414.35 μg g-1 dry weight) was obtained for P. arborescens subsp. maderensis extract. This selenocompound is already described as a hydroxyl radical scavenger is reported in this work as also possessing peroxyl radical scavenging capacity. This work is a good illustration of different phytomolecules (flavonoids, organic acids and selenocompounds), presents in leaves of the five traditional medicinal plants endemic to Macaronesia, all exhibiting antioxidant properties.
Keywords: antioxidant; L-ascorbic acid; selenomethionine; flavonoid; Macaronesia plants
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Tavares, L.; Carrilho, D.; Tyagi, M.; Barata, D.; Serra, A.T.; Duarte, C.M.M.; Duarte, R.O.; Feliciano, R.P.; Bronze, M.R.; Chicau, P.; Espírito-Santo, M.D.; Ferreira, R.B.; Dos Santos, C.N. Antioxidant Capacity of Macaronesian Traditional Medicinal Plants. Molecules 2010, 15, 2576-2592.
Tavares L, Carrilho D, Tyagi M, Barata D, Serra AT, Duarte CMM, Duarte RO, Feliciano RP, Bronze MR, Chicau P, Espírito-Santo MD, Ferreira RB, Dos Santos CN. Antioxidant Capacity of Macaronesian Traditional Medicinal Plants. Molecules. 2010; 15(4):2576-2592.
Tavares, Lucélia; Carrilho, Dina; Tyagi, Meenu; Barata, David; Serra, Ana Teresa; Duarte, Catarina Maria Martins; Duarte, Rui Oliveira; Feliciano, Rodrigo Pedro; Bronze, Maria Rosário; Chicau, Paula; Espírito-Santo, Maria Dalila; Ferreira, Ricardo Boavida; Dos Santos, Cláudia Nunes. 2010. "Antioxidant Capacity of Macaronesian Traditional Medicinal Plants." Molecules 15, no. 4: 2576-2592.