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Pharmacological Effects of Rutaecarpine as a Cardiovascular Protective Agent
Department of Pharmaceutics, The Third XiangYa Hospital of Central South University, Changsha 410013, China
Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha 410078, China
* Author to whom correspondence should be addressed.
Received: 3 February 2010; in revised form: 1 March 2010 / Accepted: 8 March 2010 / Published: 15 March 2010
Abstract: Many studies indicate that traditional Chinese herbs are beneficial in the prevention and treatment of cardiovascular diseases. Evodia rutaecarpa (‘Wu-Chu-Yu’)remains the most popular and multi-purpose herb traditionally used in China for treatment of headache, abdominal pain, postpartum hemorrhage, dysentery and amenorrhea. Rutaecarpine is one of the intriguing indolopyridoquinazoline alkaloids isolated from ‘Wu-Chu-Yu’. Rutaecarpine has been shown to have cardiovascular biological effects such as inotropic and chronotropic, vasorelaxant, anti-platelet aggregation and anti-inflammatory effects. Furthermore, it has been reported that rutaecarpine has beneficial effects on some cardiovascular diseases. This review summarizes data on the cardiovascular pharmacological actions of rutaecarpine the published over the recent years, aiming to provide more evidence supporting its use in the treatment of cardiovascular diseases.
Keywords: rutaecarpine; cardiac protection; vasodilator; anti platelet aggregation; anti inflammation
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MDPI and ACS Style
Jia, S.; Hu, C. Pharmacological Effects of Rutaecarpine as a Cardiovascular Protective Agent. Molecules 2010, 15, 1873-1881.
Jia S, Hu C. Pharmacological Effects of Rutaecarpine as a Cardiovascular Protective Agent. Molecules. 2010; 15(3):1873-1881.
Jia, Sujie; Hu, Changping. 2010. "Pharmacological Effects of Rutaecarpine as a Cardiovascular Protective Agent." Molecules 15, no. 3: 1873-1881.