Abstract: In this study we investigated the antimicrobial activity of magnolol on Staphylococcus aureus. The minimal inhibitory concentrations of magnolol against 31 S. aureus strains ranged from 4–32 μg/mL. In addition, hemolysin assays, Western blotting, and real-time RT-PCR were performed to investigate the effect of magnolol on α-toxin secretion by both methicillin-sensitive S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA). The results indicated that sub-inhibitory concentrations of magnolol dose-dependently inhibited the transcription of hla (the gene encoding α-toxin) in S. aureus, resulting in a reduction of α-toxin secretion and, thus, hemolytic activities.
This is an open access article distributed under the
Creative Commons Attribution License which permits unrestricted use, distribution,
and reproduction in any medium, provided the original work is properly cited.
Export to BibTeX
MDPI and ACS Style
Xiang, H.; Qiu, J.-Z.; Wang, D.-C.; Jiang, Y.-S.; Xia, L.-J.; Deng, X.-M. Influence of Magnolol on the Secretion of α-Toxin by Staphylococcus aureus . Molecules 2010, 15, 1679-1689.
Xiang H, Qiu J-Z, Wang D-C, Jiang Y-S, Xia L-J, Deng X-M. Influence of Magnolol on the Secretion of α-Toxin by Staphylococcus aureus . Molecules. 2010; 15(3):1679-1689.
Xiang, Hua; Qiu, Jia-Zhang; Wang, Da-Cheng; Jiang, You-Shuai; Xia, Li-Jie; Deng, Xu-Ming. 2010. "Influence of Magnolol on the Secretion of α-Toxin by Staphylococcus aureus ." Molecules 15, no. 3: 1679-1689.