Next Article in Journal
HTS-Driven Discovery of New Chemotypes with West Nile Virus Inhibitory Activity
Previous Article in Journal
A Comparative Study of the Antibacterial, Antifungal and Antioxidant Activity and Total Content of Phenolic Compounds of Cell Cultures and Wild Plants of Three Endemic Species of Ephedra
Molecules 2010, 15(3), 1679-1689; doi:10.3390/molecules15031679
Article

Influence of Magnolol on the Secretion of α-Toxin by Staphylococcus aureus

1,
,
1,
,
1, 2
,
3
 and
1,*
Received: 18 January 2010 / Revised: 8 February 2010 / Accepted: 2 March 2010 / Published: 12 March 2010
Download PDF [400 KB, uploaded 18 June 2014]

Abstract

In this study we investigated the antimicrobial activity of magnolol on Staphylococcus aureus. The minimal inhibitory concentrations of magnolol against 31 S. aureus strains ranged from 4–32 μg/mL. In addition, hemolysin assays, Western blotting, and real-time RT-PCR were performed to investigate the effect of magnolol on α-toxin secretion by both methicillin-sensitive S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA). The results indicated that sub-inhibitory concentrations of magnolol dose-dependently inhibited the transcription of hla (the gene encoding α-toxin) in S. aureus, resulting in a reduction of α-toxin secretion and, thus, hemolytic activities.
Keywords: magnolol; Staphylococcus aureus; α-toxin magnolol; Staphylococcus aureus; α-toxin
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Xiang, H.; Qiu, J.-Z.; Wang, D.-C.; Jiang, Y.-S.; Xia, L.-J.; Deng, X.-M. Influence of Magnolol on the Secretion of α-Toxin by Staphylococcus aureus . Molecules 2010, 15, 1679-1689.

View more citation formats

Related Articles

Article Metrics

Comments

Citing Articles

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert