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Molecules 2010, 15(3), 1679-1689; doi:10.3390/molecules15031679
Article

Influence of Magnolol on the Secretion of α-Toxin by Staphylococcus aureus

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Received: 18 January 2010; in revised form: 8 February 2010 / Accepted: 2 March 2010 / Published: 12 March 2010
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Abstract: In this study we investigated the antimicrobial activity of magnolol on Staphylococcus aureus. The minimal inhibitory concentrations of magnolol against 31 S. aureus strains ranged from 4–32 μg/mL. In addition, hemolysin assays, Western blotting, and real-time RT-PCR were performed to investigate the effect of magnolol on α-toxin secretion by both methicillin-sensitive S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA). The results indicated that sub-inhibitory concentrations of magnolol dose-dependently inhibited the transcription of hla (the gene encoding α-toxin) in S. aureus, resulting in a reduction of α-toxin secretion and, thus, hemolytic activities.
Keywords: magnolol; Staphylococcus aureus; α-toxin magnolol; Staphylococcus aureus; α-toxin
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Xiang, H.; Qiu, J.-Z.; Wang, D.-C.; Jiang, Y.-S.; Xia, L.-J.; Deng, X.-M. Influence of Magnolol on the Secretion of α-Toxin by Staphylococcus aureus . Molecules 2010, 15, 1679-1689.

AMA Style

Xiang H, Qiu J-Z, Wang D-C, Jiang Y-S, Xia L-J, Deng X-M. Influence of Magnolol on the Secretion of α-Toxin by Staphylococcus aureus . Molecules. 2010; 15(3):1679-1689.

Chicago/Turabian Style

Xiang, Hua; Qiu, Jia-Zhang; Wang, Da-Cheng; Jiang, You-Shuai; Xia, Li-Jie; Deng, Xu-Ming. 2010. "Influence of Magnolol on the Secretion of α-Toxin by Staphylococcus aureus ." Molecules 15, no. 3: 1679-1689.



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