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Influence of Magnolol on the Secretion of α-Toxin by Staphylococcus aureus
Institute of Zoonoses, College of Animal Sciences and Veterinary Medicine, Jilin University, Changchun, Jilin 130062, China
College of Life Science and Technology, Heilongjiang August First Agricultural University, Daqing, Heilongjiang 163319, China
College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangshu 225009, China
These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 18 January 2010; in revised form: 8 February 2010 / Accepted: 2 March 2010 / Published: 12 March 2010
Abstract: In this study we investigated the antimicrobial activity of magnolol on Staphylococcus aureus. The minimal inhibitory concentrations of magnolol against 31 S. aureus strains ranged from 4–32 μg/mL. In addition, hemolysin assays, Western blotting, and real-time RT-PCR were performed to investigate the effect of magnolol on α-toxin secretion by both methicillin-sensitive S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA). The results indicated that sub-inhibitory concentrations of magnolol dose-dependently inhibited the transcription of hla (the gene encoding α-toxin) in S. aureus, resulting in a reduction of α-toxin secretion and, thus, hemolytic activities.
Keywords: magnolol; Staphylococcus aureus; α-toxin
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Xiang, H.; Qiu, J.-Z.; Wang, D.-C.; Jiang, Y.-S.; Xia, L.-J.; Deng, X.-M. Influence of Magnolol on the Secretion of α-Toxin by Staphylococcus aureus . Molecules 2010, 15, 1679-1689.
Xiang H, Qiu J-Z, Wang D-C, Jiang Y-S, Xia L-J, Deng X-M. Influence of Magnolol on the Secretion of α-Toxin by Staphylococcus aureus . Molecules. 2010; 15(3):1679-1689.
Xiang, Hua; Qiu, Jia-Zhang; Wang, Da-Cheng; Jiang, You-Shuai; Xia, Li-Jie; Deng, Xu-Ming. 2010. "Influence of Magnolol on the Secretion of α-Toxin by Staphylococcus aureus ." Molecules 15, no. 3: 1679-1689.