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Molecules 2010, 15(3), 1679-1689; doi:10.3390/molecules15031679

Influence of Magnolol on the Secretion of α-Toxin by Staphylococcus aureus

1, 2
1 Institute of Zoonoses, College of Animal Sciences and Veterinary Medicine, Jilin University, Changchun, Jilin 130062, China 2 College of Life Science and Technology, Heilongjiang August First Agricultural University, Daqing, Heilongjiang 163319, China 3 College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangshu 225009, China These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 18 January 2010 / Revised: 8 February 2010 / Accepted: 2 March 2010 / Published: 12 March 2010
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In this study we investigated the antimicrobial activity of magnolol on Staphylococcus aureus. The minimal inhibitory concentrations of magnolol against 31 S. aureus strains ranged from 4–32 μg/mL. In addition, hemolysin assays, Western blotting, and real-time RT-PCR were performed to investigate the effect of magnolol on α-toxin secretion by both methicillin-sensitive S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA). The results indicated that sub-inhibitory concentrations of magnolol dose-dependently inhibited the transcription of hla (the gene encoding α-toxin) in S. aureus, resulting in a reduction of α-toxin secretion and, thus, hemolytic activities.
Keywords: magnolol; Staphylococcus aureus; α-toxin magnolol; Staphylococcus aureus; α-toxin
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Xiang, H.; Qiu, J.-Z.; Wang, D.-C.; Jiang, Y.-S.; Xia, L.-J.; Deng, X.-M. Influence of Magnolol on the Secretion of α-Toxin by Staphylococcus aureus . Molecules 2010, 15, 1679-1689.

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