Molecules 2010, 15(3), 1232-1241; doi:10.3390/molecules15031232
Article

The Influence of α-, β-, and γ-Melanocyte Stimulating Hormone on Acetaminophen Induced Liver Lesions in Male CBA Mice

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Received: 2 February 2010; in revised form: 2 March 2010 / Accepted: 3 March 2010 / Published: 3 March 2010
(This article belongs to the collection Prodrugs)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Research over the past decade has indicated that melanocortin peptides are potent inhibitors of inflammation and a promising source of new anti-inflammatory and cytoprotective therapies. The purpose of the present paper is to compare protective effects of α-, β-, and γ-melanocyte stimulating hormone on acetaminophen induced liver lesions in male CBA mice. Acetaminophen was applied intragastrically in a dose of 150 mg/kg, and tested substances were applied intraperitoneally 1 hour before acetaminophen. Mice were sacrificed after 24 hours and intensity of liver injury was estimated by measurement of plasma transaminase activity (AST and ALT) and histopathological grading of lesions. It was found that α-, β-, and γ-MSH decrease intensity of lesions by both criteria in a dose-dependent manner.
Keywords: melanocortins; alpha-MSH; beta-MSH; gamma-MSH; acetaminophen; liver
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MDPI and ACS Style

Blagaić, V.; Houra, K.; Turčić, P.; Štambuk, N.; Konjevoda, P.; Boban-Blagaić, A.; Kelava, T.; Kos, M.; Aralica, G.; Čulo, F. The Influence of α-, β-, and γ-Melanocyte Stimulating Hormone on Acetaminophen Induced Liver Lesions in Male CBA Mice. Molecules 2010, 15, 1232-1241.

AMA Style

Blagaić V, Houra K, Turčić P, Štambuk N, Konjevoda P, Boban-Blagaić A, Kelava T, Kos M, Aralica G, Čulo F. The Influence of α-, β-, and γ-Melanocyte Stimulating Hormone on Acetaminophen Induced Liver Lesions in Male CBA Mice. Molecules. 2010; 15(3):1232-1241.

Chicago/Turabian Style

Blagaić, Vladimir; Houra, Karlo; Turčić, Petra; Štambuk, Nikola; Konjevoda, Paško; Boban-Blagaić, Alenka; Kelava, Tomislav; Kos, Marina; Aralica, Gorana; Čulo, Filip. 2010. "The Influence of α-, β-, and γ-Melanocyte Stimulating Hormone on Acetaminophen Induced Liver Lesions in Male CBA Mice." Molecules 15, no. 3: 1232-1241.

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