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Molecules 2010, 15(3), 1232-1241; doi:10.3390/molecules15031232

The Influence of α-, β-, and γ-Melanocyte Stimulating Hormone on Acetaminophen Induced Liver Lesions in Male CBA Mice

University Hospital “Sveti Duh”, Sveti Duh 64, 10000 Zagreb, Croatia
University Hospital “Sestre milosrdnice”, Vinogradska cesta 29, 10000 Zagreb, Croatia
Faculty of Pharmacy and Biochemistry, University of Zagreb, Domagojeva 2, 10000 Zagreb, Croatia
Ruđer Bošković Institute, Bijenička cesta 54, 10002 Zagreb, Croatia
Department of Pharmacology, School of Medicine, University of Zagreb, Šalata 11, 10000 Zagreb, Croatia
Department of Physiology, School of Medicine, University of Zagreb, Šalata 3, 10000 Zagreb, Croatia
University Hospital Dubrava, Avenija Gojka Šuška 6, 10000 Zagreb, Croatia
Authors to whom correspondence should be addressed.
Received: 2 February 2010 / Revised: 2 March 2010 / Accepted: 3 March 2010 / Published: 3 March 2010
(This article belongs to the Special Issue Prodrugs)
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Research over the past decade has indicated that melanocortin peptides are potent inhibitors of inflammation and a promising source of new anti-inflammatory and cytoprotective therapies. The purpose of the present paper is to compare protective effects of α-, β-, and γ-melanocyte stimulating hormone on acetaminophen induced liver lesions in male CBA mice. Acetaminophen was applied intragastrically in a dose of 150 mg/kg, and tested substances were applied intraperitoneally 1 hour before acetaminophen. Mice were sacrificed after 24 hours and intensity of liver injury was estimated by measurement of plasma transaminase activity (AST and ALT) and histopathological grading of lesions. It was found that α-, β-, and γ-MSH decrease intensity of lesions by both criteria in a dose-dependent manner.
Keywords: melanocortins; alpha-MSH; beta-MSH; gamma-MSH; acetaminophen; liver melanocortins; alpha-MSH; beta-MSH; gamma-MSH; acetaminophen; liver

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Blagaić, V.; Houra, K.; Turčić, P.; Štambuk, N.; Konjevoda, P.; Boban-Blagaić, A.; Kelava, T.; Kos, M.; Aralica, G.; Čulo, F. The Influence of α-, β-, and γ-Melanocyte Stimulating Hormone on Acetaminophen Induced Liver Lesions in Male CBA Mice. Molecules 2010, 15, 1232-1241.

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