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Molecules 2010, 15(3), 1161-1167; doi:10.3390/molecules15031161

A New Geldanamycin Analogue from Streptomyces hygroscopicus

3,*  and 4,*
1 School of Resources and Environment, Jilin Agricultural University, Changchun, 130118, China 2 Institute of Agricultural Modernization, Jilin Agricultural University, Changchun, 130118, China 3 College of Plant Science, Jilin University, Changchun, 130062, China 4 Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan, 430074, China
* Authors to whom correspondence should be addressed.
Received: 5 January 2010 / Revised: 10 February 2010 / Accepted: 2 March 2010 / Published: 3 March 2010
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A new geldanamycin analogue was isolated from Streptomyces hygroscopicus A070101. The structure was elucidated as 11-methoxy-17-formyl-17-demethoxy-18-O-21-O-dihydrogeldanamycin (1) on the basis of extensive 1D and 2D NMR as well as HRESI-MS spectroscopic data analysis. Compound 1 showed considerable cytotoxicity (SRB) against human cancer cell lines (breast cancer MCF-7, skin melanoma SK-MEL-2 and lung carcinoma COR-L23).
Keywords: Streptomyces hygroscopicus; 11-methoxy-17-formyl-17-demethoxy-18-O-21-O-dihydrogeldanamycin; geldanamycin Streptomyces hygroscopicus; 11-methoxy-17-formyl-17-demethoxy-18-O-21-O-dihydrogeldanamycin; geldanamycin
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Zhang, H.; Sun, G.-Z.; Li, X.; Pan, H.-Y.; Zhang, Y.-S. A New Geldanamycin Analogue from Streptomyces hygroscopicus. Molecules 2010, 15, 1161-1167.

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