A New Geldanamycin Analogue from Streptomyces hygroscopicus
AbstractA new geldanamycin analogue was isolated from Streptomyces hygroscopicus A070101. The structure was elucidated as 11-methoxy-17-formyl-17-demethoxy-18-O-21-O-dihydrogeldanamycin (1) on the basis of extensive 1D and 2D NMR as well as HRESI-MS spectroscopic data analysis. Compound 1 showed considerable cytotoxicity (SRB) against human cancer cell lines (breast cancer MCF-7, skin melanoma SK-MEL-2 and lung carcinoma COR-L23).
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Zhang, H.; Sun, G.-Z.; Li, X.; Pan, H.-Y.; Zhang, Y.-S. A New Geldanamycin Analogue from Streptomyces hygroscopicus. Molecules 2010, 15, 1161-1167.
Zhang H, Sun G-Z, Li X, Pan H-Y, Zhang Y-S. A New Geldanamycin Analogue from Streptomyces hygroscopicus. Molecules. 2010; 15(3):1161-1167.Chicago/Turabian Style
Zhang, Hao; Sun, Guang-Zhi; Li, Xiang; Pan, Hong-Yu; Zhang, Yan-Sheng. 2010. "A New Geldanamycin Analogue from Streptomyces hygroscopicus." Molecules 15, no. 3: 1161-1167.