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A New Geldanamycin Analogue from Streptomyces hygroscopicus
School of Resources and Environment, Jilin Agricultural University, Changchun, 130118, China
Institute of Agricultural Modernization, Jilin Agricultural University, Changchun, 130118, China
College of Plant Science, Jilin University, Changchun, 130062, China
Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan, 430074, China
* Authors to whom correspondence should be addressed.
Received: 5 January 2010; in revised form: 10 February 2010 / Accepted: 2 March 2010 / Published: 3 March 2010
Abstract: A new geldanamycin analogue was isolated from Streptomyces hygroscopicus A070101. The structure was elucidated as 11-methoxy-17-formyl-17-demethoxy-18-O-21-O-dihydrogeldanamycin (1) on the basis of extensive 1D and 2D NMR as well as HRESI-MS spectroscopic data analysis. Compound 1 showed considerable cytotoxicity (SRB) against human cancer cell lines (breast cancer MCF-7, skin melanoma SK-MEL-2 and lung carcinoma COR-L23).
Keywords: Streptomyces hygroscopicus; 11-methoxy-17-formyl-17-demethoxy-18-O-21-O-dihydrogeldanamycin; geldanamycin
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MDPI and ACS Style
Zhang, H.; Sun, G.-Z.; Li, X.; Pan, H.-Y.; Zhang, Y.-S. A New Geldanamycin Analogue from Streptomyces hygroscopicus. Molecules 2010, 15, 1161-1167.
Zhang H, Sun G-Z, Li X, Pan H-Y, Zhang Y-S. A New Geldanamycin Analogue from Streptomyces hygroscopicus. Molecules. 2010; 15(3):1161-1167.
Zhang, Hao; Sun, Guang-Zhi; Li, Xiang; Pan, Hong-Yu; Zhang, Yan-Sheng. 2010. "A New Geldanamycin Analogue from Streptomyces hygroscopicus." Molecules 15, no. 3: 1161-1167.