Next Article in Journal
Control of Intracellular Calcium Signaling as a Neuroprotective Strategy
Previous Article in Journal
Copper-Catalyzed N-Arylation of Amides Using (S)-N-Methylpyrrolidine-2-carboxylate as the Ligand
Molecules 2010, 15(3), 1161-1167; doi:10.3390/molecules15031161

A New Geldanamycin Analogue from Streptomyces hygroscopicus

, 2
, 3
, 3,*  and 4,*
Received: 5 January 2010 / Revised: 10 February 2010 / Accepted: 2 March 2010 / Published: 3 March 2010
Download PDF [232 KB, uploaded 18 June 2014]
Abstract: A new geldanamycin analogue was isolated from Streptomyces hygroscopicus A070101. The structure was elucidated as 11-methoxy-17-formyl-17-demethoxy-18-O-21-O-dihydrogeldanamycin (1) on the basis of extensive 1D and 2D NMR as well as HRESI-MS spectroscopic data analysis. Compound 1 showed considerable cytotoxicity (SRB) against human cancer cell lines (breast cancer MCF-7, skin melanoma SK-MEL-2 and lung carcinoma COR-L23).
Keywords: Streptomyces hygroscopicus; 11-methoxy-17-formyl-17-demethoxy-18-O-21-O-dihydrogeldanamycin; geldanamycin Streptomyces hygroscopicus; 11-methoxy-17-formyl-17-demethoxy-18-O-21-O-dihydrogeldanamycin; geldanamycin
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |

MDPI and ACS Style

Zhang, H.; Sun, G.-Z.; Li, X.; Pan, H.-Y.; Zhang, Y.-S. A New Geldanamycin Analogue from Streptomyces hygroscopicus. Molecules 2010, 15, 1161-1167.

AMA Style

Zhang H, Sun G-Z, Li X, Pan H-Y, Zhang Y-S. A New Geldanamycin Analogue from Streptomyces hygroscopicus. Molecules. 2010; 15(3):1161-1167.

Chicago/Turabian Style

Zhang, Hao; Sun, Guang-Zhi; Li, Xiang; Pan, Hong-Yu; Zhang, Yan-Sheng. 2010. "A New Geldanamycin Analogue from Streptomyces hygroscopicus." Molecules 15, no. 3: 1161-1167.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert