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Molecules 2010, 15(3), 1154-1160; doi:10.3390/molecules15031154

Copper-Catalyzed N-Arylation of Amides Using (S)-N-Methylpyrrolidine-2-carboxylate as the Ligand

1 College of Chemical Engineering and Material, Heilongjiang University, Haerbin 150080, China 2 Mudanjiang Normal University, Mudanjiang 157012, China
* Author to whom correspondence should be addressed.
Received: 23 January 2010 / Revised: 25 February 2010 / Accepted: 2 March 2010 / Published: 2 March 2010
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(S)-N-methylpyrrolidine-2-carboxylate, a derivative of natural L-proline, was found to be an efficient ligand for the copper-catalyzed Goldberg-type N-arylation of amides with aryl halides under mild conditions. A variety of N-arylamides were synthesized in good to high yields.
Keywords: copper; (S)-N-methylpyrrolidine-2-carboxylate; arylations; amides copper; (S)-N-methylpyrrolidine-2-carboxylate; arylations; amides
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Wang, C.; Liu, L.; Wang, W.; Ma, D.-S.; Zhang, H. Copper-Catalyzed N-Arylation of Amides Using (S)-N-Methylpyrrolidine-2-carboxylate as the Ligand. Molecules 2010, 15, 1154-1160.

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