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Molecules 2010, 15(3), 1154-1160; doi:10.3390/molecules15031154
Article

Copper-Catalyzed N-Arylation of Amides Using (S)-N-Methylpyrrolidine-2-carboxylate as the Ligand

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Received: 23 January 2010; in revised form: 25 February 2010 / Accepted: 2 March 2010 / Published: 2 March 2010
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Abstract: (S)-N-methylpyrrolidine-2-carboxylate, a derivative of natural L-proline, was found to be an efficient ligand for the copper-catalyzed Goldberg-type N-arylation of amides with aryl halides under mild conditions. A variety of N-arylamides were synthesized in good to high yields.
Keywords: copper; (S)-N-methylpyrrolidine-2-carboxylate; arylations; amides copper; (S)-N-methylpyrrolidine-2-carboxylate; arylations; amides
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Wang, C.; Liu, L.; Wang, W.; Ma, D.-S.; Zhang, H. Copper-Catalyzed N-Arylation of Amides Using (S)-N-Methylpyrrolidine-2-carboxylate as the Ligand. Molecules 2010, 15, 1154-1160.

AMA Style

Wang C, Liu L, Wang W, Ma D-S, Zhang H. Copper-Catalyzed N-Arylation of Amides Using (S)-N-Methylpyrrolidine-2-carboxylate as the Ligand. Molecules. 2010; 15(3):1154-1160.

Chicago/Turabian Style

Wang, Chaoyu; Liu, Lijuan; Wang, Wei; Ma, Dong-Sheng; Zhang, Hua. 2010. "Copper-Catalyzed N-Arylation of Amides Using (S)-N-Methylpyrrolidine-2-carboxylate as the Ligand." Molecules 15, no. 3: 1154-1160.



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