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Molecules 2010, 15(3), 1154-1160; doi:10.3390/molecules15031154
Article

Copper-Catalyzed N-Arylation of Amides Using (S)-N-Methylpyrrolidine-2-carboxylate as the Ligand

1,2
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1
 and
1,*
1 College of Chemical Engineering and Material, Heilongjiang University, Haerbin 150080, China 2 Mudanjiang Normal University, Mudanjiang 157012, China
* Author to whom correspondence should be addressed.
Received: 23 January 2010 / Revised: 25 February 2010 / Accepted: 2 March 2010 / Published: 2 March 2010
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Abstract

(S)-N-methylpyrrolidine-2-carboxylate, a derivative of natural L-proline, was found to be an efficient ligand for the copper-catalyzed Goldberg-type N-arylation of amides with aryl halides under mild conditions. A variety of N-arylamides were synthesized in good to high yields.
Keywords: copper; (S)-N-methylpyrrolidine-2-carboxylate; arylations; amides copper; (S)-N-methylpyrrolidine-2-carboxylate; arylations; amides
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Wang, C.; Liu, L.; Wang, W.; Ma, D.-S.; Zhang, H. Copper-Catalyzed N-Arylation of Amides Using (S)-N-Methylpyrrolidine-2-carboxylate as the Ligand. Molecules 2010, 15, 1154-1160.

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