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Molecules 2010, 15(12), 9174-9183; doi:10.3390/molecules15129174

Synthesis and Biological Activity of trans-Tiliroside Derivatives as Potent Anti-Diabetic Agents

1
School of Pharmaceutical Sciences, Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China
2
Chinese People’s Armed Police Forces, Tianjin Provincial Corps Hospital, Tianjin 300162, China
3
Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
*
Author to whom correspondence should be addressed.
Received: 29 October 2010 / Revised: 7 December 2010 / Accepted: 8 December 2010 / Published: 10 December 2010
(This article belongs to the Special Issue Structure-Based Drug Design)
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Abstract

A set of novel trans-tiliroside derivatives were synthesized. The structures of the derivatives were identified by their IR, 1H-NMR, and MS spectra analysis. Their anti-diabetic activities were evaluated on the insulin resistant (IR) HepG2 cell model. As a result, compounds 7a, 7c, 7h, and trans-tiliroside exhibited significant glucose consumption-enhancing effects in IR-HepG2 cells compared with the positive control (metformin). This research provides useful clues for further design and discovery of anti-diabetic agents.
Keywords: trans-tiliroside; derivative synthesis; Novozyme435; anti-diabetic activity trans-tiliroside; derivative synthesis; Novozyme435; anti-diabetic activity
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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Zhu, Y.; Zhang, Y.; Liu, Y.; Chu, H.; Duan, H. Synthesis and Biological Activity of trans-Tiliroside Derivatives as Potent Anti-Diabetic Agents. Molecules 2010, 15, 9174-9183.

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