Molecules 2010, 15(12), 9174-9183; doi:10.3390/molecules15129174
Article

Synthesis and Biological Activity of trans-Tiliroside Derivatives as Potent Anti-Diabetic Agents

1,2email, 3email, 1email, 1email and 1,* email
Received: 29 October 2010; in revised form: 7 December 2010 / Accepted: 8 December 2010 / Published: 10 December 2010
(This article belongs to the Special Issue Structure-Based Drug Design)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: A set of novel trans-tiliroside derivatives were synthesized. The structures of the derivatives were identified by their IR, 1H-NMR, and MS spectra analysis. Their anti-diabetic activities were evaluated on the insulin resistant (IR) HepG2 cell model. As a result, compounds 7a, 7c, 7h, and trans-tiliroside exhibited significant glucose consumption-enhancing effects in IR-HepG2 cells compared with the positive control (metformin). This research provides useful clues for further design and discovery of anti-diabetic agents.
Keywords: trans-tiliroside; derivative synthesis; Novozyme435; anti-diabetic activity
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MDPI and ACS Style

Zhu, Y.; Zhang, Y.; Liu, Y.; Chu, H.; Duan, H. Synthesis and Biological Activity of trans-Tiliroside Derivatives as Potent Anti-Diabetic Agents. Molecules 2010, 15, 9174-9183.

AMA Style

Zhu Y, Zhang Y, Liu Y, Chu H, Duan H. Synthesis and Biological Activity of trans-Tiliroside Derivatives as Potent Anti-Diabetic Agents. Molecules. 2010; 15(12):9174-9183.

Chicago/Turabian Style

Zhu, Yujin; Zhang, Yanjun; Liu, Yi; Chu, Hongwan; Duan, Hongquan. 2010. "Synthesis and Biological Activity of trans-Tiliroside Derivatives as Potent Anti-Diabetic Agents." Molecules 15, no. 12: 9174-9183.

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