Next Article in Journal
Volatile Compounds of Young Wines from Cabernet Sauvignon, Cabernet Gernischet and Chardonnay Varieties Grown in the Loess Plateau Region of China
Previous Article in Journal
Sonogashira Reaction of Aryl and Heteroaryl Halides with Terminal Alkynes Catalyzed by a Highly Efficient and Recyclable Nanosized MCM-41 Anchored Palladium Bipyridyl Complex
Previous Article in Special Issue
Lead Generation and Optimization Based on Protein-Ligand Complementarity
Molecules 2010, 15(12), 9174-9183; doi:10.3390/molecules15129174

Synthesis and Biological Activity of trans-Tiliroside Derivatives as Potent Anti-Diabetic Agents

1 School of Pharmaceutical Sciences, Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China 2 Chinese People’s Armed Police Forces, Tianjin Provincial Corps Hospital, Tianjin 300162, China 3 Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
* Author to whom correspondence should be addressed.
Received: 29 October 2010 / Revised: 7 December 2010 / Accepted: 8 December 2010 / Published: 10 December 2010
(This article belongs to the Special Issue Structure-Based Drug Design)
Download PDF [181 KB, uploaded 18 June 2014]


A set of novel trans-tiliroside derivatives were synthesized. The structures of the derivatives were identified by their IR, 1H-NMR, and MS spectra analysis. Their anti-diabetic activities were evaluated on the insulin resistant (IR) HepG2 cell model. As a result, compounds 7a, 7c, 7h, and trans-tiliroside exhibited significant glucose consumption-enhancing effects in IR-HepG2 cells compared with the positive control (metformin). This research provides useful clues for further design and discovery of anti-diabetic agents.
Keywords: trans-tiliroside; derivative synthesis; Novozyme435; anti-diabetic activity trans-tiliroside; derivative synthesis; Novozyme435; anti-diabetic activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
MDPI and ACS Style

Zhu, Y.; Zhang, Y.; Liu, Y.; Chu, H.; Duan, H. Synthesis and Biological Activity of trans-Tiliroside Derivatives as Potent Anti-Diabetic Agents. Molecules 2010, 15, 9174-9183.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


Cited By

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert