Next Article in Journal
Synthesis, Characterization and Pharmacological Evaluation of 1-(2-Chloro-6-Fluorophenyl)-5-Methylindolin-2-One: A New Anti-Inflammatory Compound with Reduced Gastric Ulceration Properties
Next Article in Special Issue
Chemistry of the Enaminone of 1-Acetylnaphthalene under Microwave Irradiation Using Chitosan as a Green Catalyst
Previous Article in Journal
Monocyclic Phenolic Acids; Hydroxy- and Polyhydroxybenzoic Acids: Occurrence and Recent Bioactivity Studies
Previous Article in Special Issue
Heterocyclic Analogues of Xanthone and Xanthione. 1H-Pyrano[2,3-c:6,5-c]dipyrazol-4(7H)-ones and Thiones: Synthesis and NMR Data
Article Menu

Article Versions

Export Article

Open AccessReview
Molecules 2010, 15(11), 8006-8038; doi:10.3390/molecules15118006

Recent Advance in Heterocyclic Organozinc and Organomanganese Compounds; Direct Synthetic Routes and Application in Organic Synthesis

1
Department of Chemistry, Dankook University; 29 Anseo Cheonan Chungnam, 330-714, Korea
2
Rieke Metals, Inc.; 1001 Kingbird Rd. Lincoln, NE 68512, USA
*
Author to whom correspondence should be addressed.
Received: 17 September 2010 / Revised: 1 November 2010 / Accepted: 4 November 2010 / Published: 8 November 2010
(This article belongs to the Special Issue Advances in Heterocyclic Chemistry)
Download PDF [406 KB, uploaded 18 June 2014]

Abstract

A practical synthetic route for the preparation of 2-pyridyl and 3-pyridyl derivatives has been accomplished by utilizing a simple coupling reaction of stable 2-pyridylzinc bromides and 3-pyridylzinc bromides. The organozincs used in this study were easily prepared via the direct insertion of active zinc into the corresponding bromopyridines. The subsequent coupling reactions with a variety of different electrophiles have afforded the corresponding coupling products. Using highly active manganese, a variety of Grignard-type organomanganese reagents have been obtained. The subsequent coupling reactions of the resulting organomanganese reagents with several electrophiles have also been accomplished under mild conditions.
Keywords: highly active metals; organozinc; organomanganese; heterocyclic compounds highly active metals; organozinc; organomanganese; heterocyclic compounds
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Kim, S.-H.; Rieke, R.D. Recent Advance in Heterocyclic Organozinc and Organomanganese Compounds; Direct Synthetic Routes and Application in Organic Synthesis. Molecules 2010, 15, 8006-8038.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top