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Molecules 2010, 15(11), 8006-8038; doi:10.3390/molecules15118006
Review

Recent Advance in Heterocyclic Organozinc and Organomanganese Compounds; Direct Synthetic Routes and Application in Organic Synthesis

1
 and 2,*
Received: 17 September 2010; in revised form: 1 November 2010 / Accepted: 4 November 2010 / Published: 8 November 2010
(This article belongs to the Special Issue Advances in Heterocyclic Chemistry)
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Abstract: A practical synthetic route for the preparation of 2-pyridyl and 3-pyridyl derivatives has been accomplished by utilizing a simple coupling reaction of stable 2-pyridylzinc bromides and 3-pyridylzinc bromides. The organozincs used in this study were easily prepared via the direct insertion of active zinc into the corresponding bromopyridines. The subsequent coupling reactions with a variety of different electrophiles have afforded the corresponding coupling products. Using highly active manganese, a variety of Grignard-type organomanganese reagents have been obtained. The subsequent coupling reactions of the resulting organomanganese reagents with several electrophiles have also been accomplished under mild conditions.
Keywords: highly active metals; organozinc; organomanganese; heterocyclic compounds highly active metals; organozinc; organomanganese; heterocyclic compounds
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Kim, S.-H.; Rieke, R.D. Recent Advance in Heterocyclic Organozinc and Organomanganese Compounds; Direct Synthetic Routes and Application in Organic Synthesis. Molecules 2010, 15, 8006-8038.

AMA Style

Kim S-H, Rieke RD. Recent Advance in Heterocyclic Organozinc and Organomanganese Compounds; Direct Synthetic Routes and Application in Organic Synthesis. Molecules. 2010; 15(11):8006-8038.

Chicago/Turabian Style

Kim, Seung-Hoi; Rieke, Reuben D. 2010. "Recent Advance in Heterocyclic Organozinc and Organomanganese Compounds; Direct Synthetic Routes and Application in Organic Synthesis." Molecules 15, no. 11: 8006-8038.


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