Molecules 2010, 15(10), 6795-6809; doi:10.3390/molecules15106795
Article

Synthesis and Antioxidant Activity of Some New Coumarinyl-1,3-Thiazolidine-4-ones

1 Department of Applied Chemistry and Ecology, Faculty of Food Technology, J. J. Strossmayer University, Franje Kuhača 20, 31 000 Osijek, Croatia 2 Department of Biology, J. J. Strossmayer University, Trg Ljudevita Gaja 6, 31 000 Osijek, Croatia
* Author to whom correspondence should be addressed.
Received: 12 June 2010; in revised form: 21 September 2010 / Accepted: 27 September 2010 / Published: 29 September 2010
PDF Full-text Download PDF Full-Text [263 KB, uploaded 30 September 2010 11:39 CEST]
Abstract: A series of Schiff’s bases (E)-N-2-aryliden-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetohydrazides 2a-l and N-(2-(substituted phenyl)-4-oxo-thiazolidin-3-yl)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetamides 3a-l were synthesized and evaluated for their antioxidant activity by the phosphomolybdenum method. Most of the Schiff’s bases and thiazolidine-4-ones bearing two hydroxyl groups on the phenyl ring showed excellent antioxidant activity in comparison with ascorbic acid. Preliminary investigation on cytotoxic and antifungal activity was done on some representative samples.
Keywords: coumarin; hydrazides; aromatic Schiffs bases; N-(2-aryl-4-oxo-thiazolidin-3-yl)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetamide; antioxidant activity; biological activity

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Čačić, M.; Molnar, M.; Šarkanj, B.; Has-Schön, E.; Rajković, V. Synthesis and Antioxidant Activity of Some New Coumarinyl-1,3-Thiazolidine-4-ones. Molecules 2010, 15, 6795-6809.

AMA Style

Čačić M, Molnar M, Šarkanj B, Has-Schön E, Rajković V. Synthesis and Antioxidant Activity of Some New Coumarinyl-1,3-Thiazolidine-4-ones. Molecules. 2010; 15(10):6795-6809.

Chicago/Turabian Style

Čačić, Milan; Molnar, Maja; Šarkanj, Bojan; Has-Schön, Elizabeta; Rajković, Valentina. 2010. "Synthesis and Antioxidant Activity of Some New Coumarinyl-1,3-Thiazolidine-4-ones." Molecules 15, no. 10: 6795-6809.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert