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Molecules 2010, 15(10), 6795-6809; doi:10.3390/molecules15106795
Article

Synthesis and Antioxidant Activity of Some New Coumarinyl-1,3-Thiazolidine-4-ones

1,* , 1, 1, 2 and 2
Received: 12 June 2010; in revised form: 21 September 2010 / Accepted: 27 September 2010 / Published: 29 September 2010
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Abstract: A series of Schiff’s bases (E)-N-2-aryliden-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetohydrazides 2a-l and N-(2-(substituted phenyl)-4-oxo-thiazolidin-3-yl)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetamides 3a-l were synthesized and evaluated for their antioxidant activity by the phosphomolybdenum method. Most of the Schiff’s bases and thiazolidine-4-ones bearing two hydroxyl groups on the phenyl ring showed excellent antioxidant activity in comparison with ascorbic acid. Preliminary investigation on cytotoxic and antifungal activity was done on some representative samples.
Keywords: coumarin; hydrazides; aromatic Schiffs bases; N-(2-aryl-4-oxo-thiazolidin-3-yl)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetamide; antioxidant activity; biological activity coumarin; hydrazides; aromatic Schiffs bases; N-(2-aryl-4-oxo-thiazolidin-3-yl)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetamide; antioxidant activity; biological activity
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Čačić, M.; Molnar, M.; Šarkanj, B.; Has-Schön, E.; Rajković, V. Synthesis and Antioxidant Activity of Some New Coumarinyl-1,3-Thiazolidine-4-ones. Molecules 2010, 15, 6795-6809.

AMA Style

Čačić M, Molnar M, Šarkanj B, Has-Schön E, Rajković V. Synthesis and Antioxidant Activity of Some New Coumarinyl-1,3-Thiazolidine-4-ones. Molecules. 2010; 15(10):6795-6809.

Chicago/Turabian Style

Čačić, Milan; Molnar, Maja; Šarkanj, Bojan; Has-Schön, Elizabeta; Rajković, Valentina. 2010. "Synthesis and Antioxidant Activity of Some New Coumarinyl-1,3-Thiazolidine-4-ones." Molecules 15, no. 10: 6795-6809.


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