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Synthesis and Antioxidant Activity of Some New Coumarinyl-1,3-Thiazolidine-4-ones
Department of Applied Chemistry and Ecology, Faculty of Food Technology, J. J. Strossmayer University, Franje Kuhača 20, 31 000 Osijek, Croatia
Department of Biology, J. J. Strossmayer University, Trg Ljudevita Gaja 6, 31 000 Osijek, Croatia
* Author to whom correspondence should be addressed.
Received: 12 June 2010; in revised form: 21 September 2010 / Accepted: 27 September 2010 / Published: 29 September 2010
Abstract: A series of Schiff’s bases (E)-N-2-aryliden-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetohydrazides 2a-l and N-(2-(substituted phenyl)-4-oxo-thiazolidin-3-yl)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetamides 3a-l were synthesized and evaluated for their antioxidant activity by the phosphomolybdenum method. Most of the Schiff’s bases and thiazolidine-4-ones bearing two hydroxyl groups on the phenyl ring showed excellent antioxidant activity in comparison with ascorbic acid. Preliminary investigation on cytotoxic and antifungal activity was done on some representative samples.
Keywords: coumarin; hydrazides; aromatic Schiff’s bases; N-(2-aryl-4-oxo-thiazolidin-3-yl)-2-(4-methyl-2-oxo-2H-chromen-7-yloxy)acetamide; antioxidant activity; biological activity
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Čačić, M.; Molnar, M.; Šarkanj, B.; Has-Schön, E.; Rajković, V. Synthesis and Antioxidant Activity of Some New Coumarinyl-1,3-Thiazolidine-4-ones. Molecules 2010, 15, 6795-6809.
Čačić M, Molnar M, Šarkanj B, Has-Schön E, Rajković V. Synthesis and Antioxidant Activity of Some New Coumarinyl-1,3-Thiazolidine-4-ones. Molecules. 2010; 15(10):6795-6809.
Čačić, Milan; Molnar, Maja; Šarkanj, Bojan; Has-Schön, Elizabeta; Rajković, Valentina. 2010. "Synthesis and Antioxidant Activity of Some New Coumarinyl-1,3-Thiazolidine-4-ones." Molecules 15, no. 10: 6795-6809.