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Molecules 2010, 15(1), 178-197; doi:10.3390/molecules15010178

Click Chemistry for the Synthesis of RGD-Containing Integrin Ligands

1,*  and 2,*
1 NiKem Research, via Zambeletti 25, 20021 Baranzate, Milan, Italy 2 Consorzio Interdisciplinare di Studi Biomolecolari ed Applicazioni Industriali (CISI), Via Fantoli 16/15, 20138 Milan, Italy
* Authors to whom correspondence should be addressed.
Received: 1 December 2009 / Revised: 19 December 2009 / Accepted: 31 December 2009 / Published: 6 January 2010
(This article belongs to the Special Issue Click Chemistry)
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In the last few years click chemistry reactions, and in particular coppercatalyzed cycloadditions, have been used intensively for the preparation of new bioconjugate molecules and materials applicable to biomedical and pharmaceutical areas. This review will be focused on conjugates of the tripeptide Arg-Gly-Asp formed by means of click chemistry reactions. This sequence is a well known binding motif for specific transmembrane proteins and is involved in cellular adhesion to the extracellular matrix, allowing the selective recognition of the biomolecule or polymer in which it is incorporated.
Keywords: click chemistry; RGD; pseudopeptide; biomaterials; integrins click chemistry; RGD; pseudopeptide; biomaterials; integrins
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Colombo, M.; Bianchi, A. Click Chemistry for the Synthesis of RGD-Containing Integrin Ligands. Molecules 2010, 15, 178-197.

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