Molecules 2010, 15(1), 178-197; doi:10.3390/molecules15010178
Review

Click Chemistry for the Synthesis of RGD-Containing Integrin Ligands

1,* email and 2,* email
Received: 1 December 2009; in revised form: 19 December 2009 / Accepted: 31 December 2009 / Published: 6 January 2010
(This article belongs to the Special Issue Click Chemistry)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: In the last few years click chemistry reactions, and in particular coppercatalyzed cycloadditions, have been used intensively for the preparation of new bioconjugate molecules and materials applicable to biomedical and pharmaceutical areas. This review will be focused on conjugates of the tripeptide Arg-Gly-Asp formed by means of click chemistry reactions. This sequence is a well known binding motif for specific transmembrane proteins and is involved in cellular adhesion to the extracellular matrix, allowing the selective recognition of the biomolecule or polymer in which it is incorporated.
Keywords: click chemistry; RGD; pseudopeptide; biomaterials; integrins
PDF Full-text Download PDF Full-Text [161 KB, uploaded 18 June 2014 19:31 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Colombo, M.; Bianchi, A. Click Chemistry for the Synthesis of RGD-Containing Integrin Ligands. Molecules 2010, 15, 178-197.

AMA Style

Colombo M, Bianchi A. Click Chemistry for the Synthesis of RGD-Containing Integrin Ligands. Molecules. 2010; 15(1):178-197.

Chicago/Turabian Style

Colombo, Matteo; Bianchi, Aldo. 2010. "Click Chemistry for the Synthesis of RGD-Containing Integrin Ligands." Molecules 15, no. 1: 178-197.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert