Click Chemistry
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".
Deadline for manuscript submissions: closed (31 July 2010) | Viewed by 57956
Special Issue Editor
Special Issue Information
Dear Colleagues,
Click-chemistry is a new way of thinking molecular construction that emerges at the turn of this century. This concept, introduced by K. B. Sharpless, is based on the use of fast and efficient reactions between building blocks that opens the way to quasi-illimited variations in chemical architecture. Click-chemistry permits the construction of highly diversified structures through the use of reactive subunits, that can be joined using nucleophilic and electrophilic substitutions, ring opening reactions, cycloadditions reactions such as the copper (I)-modified Huisgen reaction and the Diels-Alder one, additions to unsaturated bonds, carbonyl chemistry, and so on. The scope of this new way of thinking molecular construction is large and has found many applications in classical organic synthesis, polymers and material sciences, as well as at the biological interface, with biocompatible conditions.
This Special Issue of Molecules has the objective to present articles that cover the use of click-chemistry to generate molecular diversity by organic synthesis (molecular libraries, chemical architecture, complexe structures, etc.), as well as its application at the frontier with other sciences.
Prof. Dr. Christian Girard
Guest Editor
Keywords
- click-chemistry
- organic synthesis
- molecular diversity
- methodology
- application
- interfaces with other sciences (pharmaceutical, biological, polymers, materials, etc.)
