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Adding Chemical Cross-Links to a Physical Hydrogel
Dipartimento di Scienze e Tecnologie Chimiche, Università di Roma Tor Vergata and CNR – SOFT, Italy
* Author to whom correspondence should be addressed.
Received: 30 June 2009; in revised form: 27 August 2009 / Accepted: 16 September 2009 / Published: 17 September 2009
Abstract: Synergistic hydrogels are often encountered in polysaccharide mixtures widely used in food and biopharma products. The xanthan and konjac glucomannan pair provides one of the most studied synergistic hydrogels. Recently we showed that the junction zones stabilizing the 3D structure of this gel are present as macromolecular complexes in solution formed by the partially depolymerised polysaccharidic chains. The non-covalent interactions stabilizing the structure of the polysaccharidic complex cause the melting of the ordered structure of the complex in the solution and of the hydrogels. Introduction of chemical cross-links in the 3D structure of the synergistic hydrogel removes this behaviour, adding new features to the swelling and to the viscoelastic properties of the cured hydrogel. The use of epichlorohydrin as low molecular weight cross-linker does not impact unfavourably on the viability of NIH 3T3 fibroblasts.
Keywords: hydrogels; swelling; biocompatibility; polysaccharides
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Cite This Article
MDPI and ACS Style
Paradossi, G.; Finelli, I.; Cerroni, B.; Chiessi, E. Adding Chemical Cross-Links to a Physical Hydrogel. Molecules 2009, 14, 3662-3675.
Paradossi G, Finelli I, Cerroni B, Chiessi E. Adding Chemical Cross-Links to a Physical Hydrogel. Molecules. 2009; 14(9):3662-3675.
Paradossi, Gaio; Finelli, Ivana; Cerroni, Barbara; Chiessi, Ester. 2009. "Adding Chemical Cross-Links to a Physical Hydrogel." Molecules 14, no. 9: 3662-3675.