Preparation and Characterization of Novel Gellan Gum Hydrogels Suitable for Modified Drug Release

doi:10.3390/molecules14093376

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Molecules 2009, 14(9), 3376-3391; doi:10.3390/molecules14093376

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Preparation and Characterization of Novel Gellan Gum Hydrogels Suitable for Modified Drug Release

Pietro Matricardi, Claudia Cencetti, Roberto Ria, Franco Alhaique and Tommasina Coviello*

Department of Drug Chemistry and Technologies, Faculty of Pharmacy, University of Rome “La Sapienza”, Piazzale Aldo Moro 5, 00185, Rome, Italy

* Author to whom correspondence should be addressed.

Received: 26 June 2009; in revised form: 30 July 2009 / Accepted: 31 August 2009 / Published: 3 September 2009

(This article belongs to the Special Issue Macromolecules Applied to Pharmaceutics)

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Abstract: Innovative hydrogels obtained by physical and chemical crosslinking of deacylated Gellan gum have been characterized in terms of water uptake, rheological properties and compressibility, and the behaviour of the tested materials, according to the type of the obtained network, is thoroughly discussed. The release from the various gels of loaded model molecules of different steric hindrance was also investigated and the trend of the release profiles has been related to the structures proposed for the physical and the chemical hydrogel.

Keywords: Gellan; hydrogels; modified drug release; rheology; texture analysis

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MDPI and ACS Style

Matricardi, P.; Cencetti, C.; Ria, R.; Alhaique, F.; Coviello, T. Preparation and Characterization of Novel Gellan Gum Hydrogels Suitable for Modified Drug Release. Molecules 2009, 14, 3376-3391.

AMA Style

Matricardi P., Cencetti C., Ria R., Alhaique F., Coviello T. Preparation and Characterization of Novel Gellan Gum Hydrogels Suitable for Modified Drug Release. Molecules. 2009; 14(9):3376-3391.

Chicago/Turabian Style

Matricardi, Pietro; Cencetti, Claudia; Ria, Roberto; Alhaique, Franco; Coviello, Tommasina. 2009. "Preparation and Characterization of Novel Gellan Gum Hydrogels Suitable for Modified Drug Release." Molecules 14, no. 9: 3376-3391.

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