- freely available
Tyrosinase Inhibitor Activity of Coumarin-Resveratrol Hybrids
AbstractIn the present work we report on the contribution of the coumarin moiety to tyrosinase inhibition. Coumarin-resveratrol hybrids 1-8 have been resynthesized to investigate the structure-activity relationships and the IC50 values of these compounds were measured. The results showed that these compounds exhibited tyrosinase inhibitory activity. Compound 3-(3’,4’,5’-trihydroxyphenyl)-6,8-dihydroxycoumarin (8)is the most potentcompound (0.27 mM), more so than umbelliferone (0.42 mM), used as reference compound. The kinetic studies revealed that compound 8 caused non-competitive tyrosinase inhibition.
Share & Cite This Article
Fais, A.; Corda, M.; Era, B.; Fadda, M.B.; Matos, M.J.; Quezada q, E.; Santana, L.; Picciau, C.; Podda, G.; Delogu, G. Tyrosinase Inhibitor Activity of Coumarin-Resveratrol Hybrids. Molecules 2009, 14, 2514-2520.View more citation formats
Fais A, Corda M, Era B, Fadda MB, Matos MJ, Quezada q E, Santana L, Picciau C, Podda G, Delogu G. Tyrosinase Inhibitor Activity of Coumarin-Resveratrol Hybrids. Molecules. 2009; 14(7):2514-2520.Chicago/Turabian Style
Fais, Antonella; Corda, Marcella; Era, Benedetta; Fadda, M. Benedetta; Matos, Maria Joao; Quezada q, Elias; Santana, Lourdes; Picciau, Carmen; Podda, Gianni; Delogu, Giovanna. 2009. "Tyrosinase Inhibitor Activity of Coumarin-Resveratrol Hybrids." Molecules 14, no. 7: 2514-2520.
Notes: Multiple requests from the same IP address are counted as one view.