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Molecules 2009, 14(7), 2514-2520; doi:10.3390/molecules14072514
Article

Tyrosinase Inhibitor Activity of Coumarin-Resveratrol Hybrids

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Received: 11 May 2009 / Revised: 9 July 2009 / Accepted: 10 July 2009 / Published: 13 July 2009
(This article belongs to the Special Issue Coumarins and Xanthones)
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Abstract

In the present work we report on the contribution of the coumarin moiety to tyrosinase inhibition. Coumarin-resveratrol hybrids 1-8 have been resynthesized to investigate the structure-activity relationships and the IC50 values of these compounds were measured. The results showed that these compounds exhibited tyrosinase inhibitory activity. Compound 3-(3’,4’,5’-trihydroxyphenyl)-6,8-dihydroxycoumarin (8)is the most potentcompound (0.27 mM), more so than umbelliferone (0.42 mM), used as reference compound. The kinetic studies revealed that compound 8 caused non-competitive tyrosinase inhibition.
Keywords: tyrosinase inhibitors; resveratrol; coumarins tyrosinase inhibitors; resveratrol; coumarins
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fais, A.; Corda, M.; Era, B.; Fadda, M.B.; Matos, M.J.; Quezada q, E.; Santana, L.; Picciau, C.; Podda, G.; Delogu, G. Tyrosinase Inhibitor Activity of Coumarin-Resveratrol Hybrids. Molecules 2009, 14, 2514-2520.

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