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Molecules 2009, 14(4), 1595-1604; doi:10.3390/molecules14041595

Article

Synthesis of γ-Nitro Aliphatic Methyl Esters Via Michael Additions Promoted by Microwave Irradiation

Jaime Escalante*  and Francisco D. Díaz-Coutiño

Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos. Av. Universidad No. 1001, Col. Chamilpa, C.P. 62210 Cuernavaca, Mor., Mexico

* Author to whom correspondence should be addressed.

Received: 5 February 2009; in revised form: 21 March 2009 / Accepted: 8 April 2009 / Published: 21 April 2009

(This article belongs to the Special Issue Microwave Assisted Synthesis)

Download PDF Full-Text [152 KB, uploaded 21 April 2009 10:00 CEST]

Abstract: A simple and efficient protocol has been developed for the direct synthesis of γ-nitrobutyric acid methyl esters under microwave irradiation. This methodology reduces reaction times from days to minutes, compared to conventional conditions. Additionally, these conditions increased yields and provided cleaner reactions.

Keywords: Microwave irradiation; α; β-Unsaturated; Michael additions; γ-Nitro aliphatic methyl esters; Catalysis

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