Thermus thermophilus Strains Active in Purine Nucleoside Synthesis

doi:10.3390/molecules14031279

This article is

freely available
re-usable

Molecules 2009, 14(3), 1279-1287; doi:10.3390/molecules14031279

Article

Thermus thermophilus Strains Active in Purine Nucleoside Synthesis

Marcos Almendros ^{1, 2}, José-Vicente Sinisterra Gago ^{1, 3}^,* and José Berenguer Carlos ²

¹ Biotransformations Group. Servicio de Biotransformaciones Industriales. Parque Científico de Madrid. C/ Santiago Grisolia nº 2. 28760 Tres Cantos. Madrid, Spain ² Centro de Biología Molecular Severo Ochoa, UAM 28049 Cantoblanco. Madrid. Spain ³ Department of Organic & Pharmaceutical Chemistry. Faculty of Pharmacy. Universidad Complutense, 28040 Madrid, Spain

* Author to whom correspondence should be addressed.

Received: 26 December 2008; in revised form: 25 February 2009 / Accepted: 11 March 2009 / Published: 24 March 2009

(This article belongs to the Special Issue Nucleic Acids)

Download PDF Full-Text [105 KB, uploaded 24 March 2009 10:50 CET]

Abstract: Several strains of Thermus thermophilus were tested in order to detect purine nucleoside synthase activity using pyrimidine nucleosides as the sugar-donor and adenine or hypoxanthine as bases. High productivity values (t =1 hr) were obtained while completely avoiding adenosine-deaminase degradation of the products. N-2-deoxy-ribosyltransferase activity is described for the first time in hyperthermophilic bacteria.

Keywords: Biocatalysis; Nucleoside synthesis; Thermus thermophilus

Article Statistics

Click here to load and display the download statistics.

Cite This Article

MDPI and ACS Style

Almendros, M.; Gago, J.-V.; Carlos, J.B. Thermus thermophilus Strains Active in Purine Nucleoside Synthesis. Molecules 2009, 14, 1279-1287.

AMA Style

Almendros M., Gago J.-V., Carlos J.B. Thermus thermophilus Strains Active in Purine Nucleoside Synthesis. Molecules. 2009; 14(3):1279-1287.

Chicago/Turabian Style

Almendros, Marcos; Gago, José-Vicente Sinisterra; Carlos, José Berenguer. 2009. "Thermus thermophilus Strains Active in Purine Nucleoside Synthesis." Molecules 14, no. 3: 1279-1287.

Molecules EISSN 1420-3049 Published by MDPI Publishing, Basel, Switzerland RSS E-Mail Table of Contents Alert