Molecules 2009, 14(12), 5017-5026; doi:10.3390/molecules14125017
Article

Effects of α-Melanocortin Enantiomers on Acetaminophen-Induced Hepatotoxicity in CBA Mice

Received: 30 September 2009; in revised form: 22 November 2009 / Accepted: 30 November 2009 / Published: 2 December 2009
(This article belongs to the collection Prodrugs)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Proteins and peptides in mammals are based exclusively on L-amino acids. Recent investigations show that D-amino acids exhibit physiological effects in vivo, despite of their very small quantities. We have investigated the hepatoprotective effects of the Land D-enantiomers of α-melanocortin peptide (α-MSH). The results showed that peptideenantiomerism is related to the protective effects of melanocortin peptides in vivo. L-α-MSH exhibited potent hepatoprotective effect in the experimental model of acetaminophen induced hepatotoxicity in male CBA mice, while its D-mirror image was inefficient. Furthermore, the antibody to the L-peptide did not recognize the D-structure. The results indicate that the opposite peptide configuration may be used to modulate its function and metabolism in vivo and in vitro.
Keywords: enantiomer; α-MSH; hepatoprotection; hepatotoxicity; antibody; CD spectroscopy
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MDPI and ACS Style

Turčić, P.; Bradamante, M.; Houra, K.; Štambuk, N.; Kelava, T.; Konjevoda, P.; Kazazić, S.; Vikić-Topić, D.; Pokrić, B. Effects of α-Melanocortin Enantiomers on Acetaminophen-Induced Hepatotoxicity in CBA Mice. Molecules 2009, 14, 5017-5026.

AMA Style

Turčić P, Bradamante M, Houra K, Štambuk N, Kelava T, Konjevoda P, Kazazić S, Vikić-Topić D, Pokrić B. Effects of α-Melanocortin Enantiomers on Acetaminophen-Induced Hepatotoxicity in CBA Mice. Molecules. 2009; 14(12):5017-5026.

Chicago/Turabian Style

Turčić, Petra; Bradamante, Mirna; Houra, Karlo; Štambuk, Nikola; Kelava, Tomislav; Konjevoda, Paško; Kazazić, Saša; Vikić-Topić, Dražen; Pokrić, Biserka. 2009. "Effects of α-Melanocortin Enantiomers on Acetaminophen-Induced Hepatotoxicity in CBA Mice." Molecules 14, no. 12: 5017-5026.

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