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Molecules 2009, 14(10), 3906-3913; doi:10.3390/molecules14103906
Article

Inhibitory Effect of Three C-glycosylflavonoids from Cymbopogon citratus (Lemongrass) on Human Low Density Lipoprotein Oxidation

1,* , 1
 and
2
1 Department of Clinical Biochemistry and Immunohematology, University of Talca, Talca, Chile 2 Department of Pharmacognosy, Faculty of Pharmacy, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic
* Author to whom correspondence should be addressed.
Received: 13 August 2009 / Revised: 5 September 2009 / Accepted: 15 September 2009 / Published: 30 September 2009
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Abstract

This study assessed the inhibitory effect of three C-glycosylflavonoids from Cymbopogon citratus leaves - isoorientin (1), swertiajaponin (2) and isoorientin 2"-Orhamnoside (3) - on human LDL oxidation. Isolated LDL was incubated with compounds 1-3 and the kinetics of lipid peroxidation were assessed by conjugated diene and malondialdehyde-thiobarbituric acid reactive substances (MDA-TBARS) formation after addition of copper ions. Significant differences (p < 0.05) between the lag time phase of the control and the lag time phase in the presence of the compounds 1 (0.25 µM) and 2 (0.50 µM) were observed. After five hours of incubation all three compounds showed a significant inhibitory effect on MDA-TBARS formation with respect to the control. After six hours of incubation only compound 1 kept a remarkable antioxidant effect. This study demonstrates that isoorientin (1) is an effective inhibitor of in vitro LDL oxidation. As oxidative damage to LDL is a key event in the formation of atherosclerotic lesions, the use of this natural antioxidant may be beneficial to prevent or attenuate atherosclerosis.
Keywords: flavonoids; lemongrass; oxidized LDL; antioxidant; Cymbopogon citratus flavonoids; lemongrass; oxidized LDL; antioxidant; Cymbopogon citratus
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Orrego, R.; Leiva, E.; Cheel, J. Inhibitory Effect of Three C-glycosylflavonoids from Cymbopogon citratus (Lemongrass) on Human Low Density Lipoprotein Oxidation. Molecules 2009, 14, 3906-3913.

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