Next Article in Journal
Solid-Phase Synthesis of Optically Active Substituted 2 Aminofuranones Using an Activated Carbonate Linker
Previous Article in Journal
Design of Antimicrobially Active Small Amphiphilic Peptide Dendrimers
Article Menu

Article Versions

Export Article

Open AccessArticle
Molecules 2009, 14(10), 3906-3913; doi:10.3390/molecules14103906

Inhibitory Effect of Three C-glycosylflavonoids from Cymbopogon citratus (Lemongrass) on Human Low Density Lipoprotein Oxidation

1
Department of Clinical Biochemistry and Immunohematology, University of Talca, Talca, Chile
2
Department of Pharmacognosy, Faculty of Pharmacy, Charles University, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic
*
Author to whom correspondence should be addressed.
Received: 13 August 2009 / Revised: 5 September 2009 / Accepted: 15 September 2009 / Published: 30 September 2009
Download PDF [151 KB, uploaded 18 June 2014]   |  

Abstract

This study assessed the inhibitory effect of three C-glycosylflavonoids from Cymbopogon citratus leaves - isoorientin (1), swertiajaponin (2) and isoorientin 2"-Orhamnoside (3) - on human LDL oxidation. Isolated LDL was incubated with compounds 1-3 and the kinetics of lipid peroxidation were assessed by conjugated diene and malondialdehyde-thiobarbituric acid reactive substances (MDA-TBARS) formation after addition of copper ions. Significant differences (p < 0.05) between the lag time phase of the control and the lag time phase in the presence of the compounds 1 (0.25 µM) and 2 (0.50 µM) were observed. After five hours of incubation all three compounds showed a significant inhibitory effect on MDA-TBARS formation with respect to the control. After six hours of incubation only compound 1 kept a remarkable antioxidant effect. This study demonstrates that isoorientin (1) is an effective inhibitor of in vitro LDL oxidation. As oxidative damage to LDL is a key event in the formation of atherosclerotic lesions, the use of this natural antioxidant may be beneficial to prevent or attenuate atherosclerosis.
Keywords: flavonoids; lemongrass; oxidized LDL; antioxidant; Cymbopogon citratus flavonoids; lemongrass; oxidized LDL; antioxidant; Cymbopogon citratus
Figures

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Orrego, R.; Leiva, E.; Cheel, J. Inhibitory Effect of Three C-glycosylflavonoids from Cymbopogon citratus (Lemongrass) on Human Low Density Lipoprotein Oxidation. Molecules 2009, 14, 3906-3913.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top