Next Article in Journal
Rubiacordone A: A New Anthraquinone Glycoside from the Roots of Rubia cordifolia
Next Article in Special Issue
Factors Affecting Polyphenol Biosynthesis in Wild and Field Grown St. John’s Wort (Hypericum perforatum L. Hypericaceae/Guttiferae)
Previous Article in Journal
Biological and Pharmacological Activities of Squalene and Related Compounds: Potential Uses in Cosmetic Dermatology
Previous Article in Special Issue
Antimutagenic Activity and Radical Scavenging Activity of Water Infusions and Phenolics from Ligustrum Plants Leaves
Article Menu

Export Article

Open AccessArticle
Molecules 2009, 14(1), 555-565; doi:10.3390/molecules14010555

Optimization and Comparison of Five Methods for Extraction of Coniferyl Ferulate from Angelica sinensis

1
Institute of Chinese Medical Sciences, University of Macau, Macao, P.R. China
2
Jiangsu Key Laboratory for TCM Formulae Research, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, P.R. China
*
Author to whom correspondence should be addressed.
Received: 15 November 2008 / Revised: 15 January 2009 / Accepted: 19 January 2009 / Published: 23 January 2009
(This article belongs to the Special Issue Phenolics and Polyphenolics)
View Full-Text   |   Download PDF [555 KB, uploaded 18 June 2014]   |  

Abstract

Coniferyl ferulate, which is noted for its multiple pharmacological activities and chemical instability, is abundant in Angelica sinensis. In this paper, five methods, namely sonication extraction (SE), pressurized liquid extraction (PLE), supercritical fluid extraction (SFE), hydrodistillation (HD) and decoction (DC) for extraction of coniferyl ferulate, as well as ferulic acid, Z/E-ligustilide and Z/E-butylidenephthalide, from A. sinensis were optimized and compared. The results showed that the order of extraction efficiency was: PLE»SE>SFE>>HD, DC. The compositions of the SE, PLE and SFE extracts, which had a high ratio of coniferyl ferulate, were very similar, while no coniferyl ferulate was obtained by HD and DC, though they had high selectivity for the extraction of ligustilide and ferulic acid, respectively. It was noteworthy that the content of ligustilide and coniferyl ferulate was not detectable in the decoction, the commonly used oral administration form of Traditional Chinese Medicines in clinical practice. View Full-Text
Keywords: Hydrodistillation; Supercritical fluid extraction; Pressurized liquid extraction; Angelica sinensis; Coniferyl ferulate; Sonication Hydrodistillation; Supercritical fluid extraction; Pressurized liquid extraction; Angelica sinensis; Coniferyl ferulate; Sonication
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Xie, J.-J.; Lu, J.; Qian, Z.-M.; Yu, Y.; Duan, J.-A.; Li, S.-P. Optimization and Comparison of Five Methods for Extraction of Coniferyl Ferulate from Angelica sinensis. Molecules 2009, 14, 555-565.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top