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Optimization and Comparison of Five Methods for Extraction of Coniferyl Ferulate from Angelica sinensis
Institute of Chinese Medical Sciences, University of Macau, Macao, P.R. China
Jiangsu Key Laboratory for TCM Formulae Research, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210029, P.R. China
* Author to whom correspondence should be addressed.
Received: 15 November 2008; in revised form: 15 January 2009 / Accepted: 19 January 2009 / Published: 23 January 2009
Abstract: Coniferyl ferulate, which is noted for its multiple pharmacological activities and chemical instability, is abundant in Angelica sinensis. In this paper, five methods, namely sonication extraction (SE), pressurized liquid extraction (PLE), supercritical fluid extraction (SFE), hydrodistillation (HD) and decoction (DC) for extraction of coniferyl ferulate, as well as ferulic acid, Z/E-ligustilide and Z/E-butylidenephthalide, from A. sinensis were optimized and compared. The results showed that the order of extraction efficiency was: PLE»SE>SFE>>HD, DC. The compositions of the SE, PLE and SFE extracts, which had a high ratio of coniferyl ferulate, were very similar, while no coniferyl ferulate was obtained by HD and DC, though they had high selectivity for the extraction of ligustilide and ferulic acid, respectively. It was noteworthy that the content of ligustilide and coniferyl ferulate was not detectable in the decoction, the commonly used oral administration form of Traditional Chinese Medicines in clinical practice.
Keywords: Hydrodistillation; Supercritical fluid extraction; Pressurized liquid extraction; Angelica sinensis; Coniferyl ferulate; Sonication
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MDPI and ACS Style
Xie, J.-J.; Lu, J.; Qian, Z.-M.; Yu, Y.; Duan, J.-A.; Li, S.-P. Optimization and Comparison of Five Methods for Extraction of Coniferyl Ferulate from Angelica sinensis. Molecules 2009, 14, 555-565.
Xie J-J, Lu J, Qian Z-M, Yu Y, Duan J-A, Li S-P. Optimization and Comparison of Five Methods for Extraction of Coniferyl Ferulate from Angelica sinensis. Molecules. 2009; 14(1):555-565.
Xie, Jing-Jing; Lu, Jia; Qian, Zheng-Ming; Yu, Yue; Duan, Jin-Ao; Li, Shao-Ping. 2009. "Optimization and Comparison of Five Methods for Extraction of Coniferyl Ferulate from Angelica sinensis." Molecules 14, no. 1: 555-565.