Molecules 2009, 14(1), 509-518; doi:10.3390/molecules14010509
Article

Antimutagenic Activity and Radical Scavenging Activity of Water Infusions and Phenolics from Ligustrum Plants Leaves

Milan Nagy 1,* email, Lívia Križková 2 email, Pavel Mučaji 1 email, Zuzana Kontšeková 1 email, František Šeršeň 3 email and Juraj Krajčovič 2 email
1 Department of Pharmacognosy and Botany, Faculty of Pharmacy, Comenius University, Odbojarov 10, 83232 Bratislava, Slovak Republic 2 Institute of Cell Biology, Faculty of Natural Sciences, Comenius University, Mlynská dolina, 84215 Bratislava, Slovak Republic 3 Institute of Chemistry, Faculty of Natural Sciences, Comenius University, Mlynská dolina, 84215 Bratislava, Slovak Republic
* Author to whom correspondence should be addressed.
Received: 24 November 2008; in revised form: 15 January 2009 / Accepted: 21 January 2009 / Published: 22 January 2009
(This article belongs to the Special Issue Phenolics and Polyphenolics)
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Abstract: Water infusions of Ligustrum delavayanum and Ligustrum vulgare leaves and eight phenolics isolated therefrom have been assayed in vitro on ofloxacin-induced genotoxicity in the unicellular flagellate Euglena gracilis. The tested compounds luteolin, quercetin, luteolin-7-glucoside, luteolin-7-rutinoside, quercetin-3-rutinoside, apigenin-7-rutinoside, tyrosol and esculetin inhibited the mutagenic activity of ofloxacin (43 µM) in E. gracilis. Water infusions from leaves of L. delavayanum and L. vulgare showed higher antimutagenic effect (pt < 0.001). The activity of these samples against ofloxacin (86 µM)-induced genotoxicity was lower, but statistically significant (pt < 0.05), excluding the water infusion of L. delavayanum leaves (pt < 0.01). Efficacy of quercetin, luteolin-7-rutinoside, apigenin-7-rutinoside was insignificant. The antimutagenic effect of most phenolics we studied could be clearly ascribed to their DPPH scavenging activity, substitution patterns and lipophilicity.
Keywords: Ligustrum; Euglena gracilis; Phenolics; Antimutagenicity; Lipophilicity; DPPH

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Cite This Article

MDPI and ACS Style

Nagy, M.; Križková, L.; Mučaji, P.; Kontšeková, Z.; Šeršeň, F.; Krajčovič, J. Antimutagenic Activity and Radical Scavenging Activity of Water Infusions and Phenolics from Ligustrum Plants Leaves. Molecules 2009, 14, 509-518.

AMA Style

Nagy M, Križková L, Mučaji P, Kontšeková Z, Šeršeň F, Krajčovič J. Antimutagenic Activity and Radical Scavenging Activity of Water Infusions and Phenolics from Ligustrum Plants Leaves. Molecules. 2009; 14(1):509-518.

Chicago/Turabian Style

Nagy, Milan; Križková, Lívia; Mučaji, Pavel; Kontšeková, Zuzana; Šeršeň, František; Krajčovič, Juraj. 2009. "Antimutagenic Activity and Radical Scavenging Activity of Water Infusions and Phenolics from Ligustrum Plants Leaves." Molecules 14, no. 1: 509-518.

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