Next Article in Journal
Next Article in Special Issue
Previous Article in Journal
Previous Article in Special Issue
Molecules 2009, 14(1), 509-518; doi:10.3390/molecules14010509
Article

Antimutagenic Activity and Radical Scavenging Activity of Water Infusions and Phenolics from Ligustrum Plants Leaves

1,* , 2
, 1
, 1
, 3
 and 2
Received: 24 November 2008; in revised form: 15 January 2009 / Accepted: 21 January 2009 / Published: 22 January 2009
(This article belongs to the Special Issue Phenolics and Polyphenolics)
Download PDF [230 KB, uploaded 18 June 2014]
Abstract: Water infusions of Ligustrum delavayanum and Ligustrum vulgare leaves and eight phenolics isolated therefrom have been assayed in vitro on ofloxacin-induced genotoxicity in the unicellular flagellate Euglena gracilis. The tested compounds luteolin, quercetin, luteolin-7-glucoside, luteolin-7-rutinoside, quercetin-3-rutinoside, apigenin-7-rutinoside, tyrosol and esculetin inhibited the mutagenic activity of ofloxacin (43 µM) in E. gracilis. Water infusions from leaves of L. delavayanum and L. vulgare showed higher antimutagenic effect (pt < 0.001). The activity of these samples against ofloxacin (86 µM)-induced genotoxicity was lower, but statistically significant (pt < 0.05), excluding the water infusion of L. delavayanum leaves (pt < 0.01). Efficacy of quercetin, luteolin-7-rutinoside, apigenin-7-rutinoside was insignificant. The antimutagenic effect of most phenolics we studied could be clearly ascribed to their DPPH scavenging activity, substitution patterns and lipophilicity.
Keywords: Ligustrum; Euglena gracilis; Phenolics; Antimutagenicity; Lipophilicity; DPPH Ligustrum; Euglena gracilis; Phenolics; Antimutagenicity; Lipophilicity; DPPH
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Export to BibTeX |
EndNote


MDPI and ACS Style

Nagy, M.; Križková, L.; Mučaji, P.; Kontšeková, Z.; Šeršeň, F.; Krajčovič, J. Antimutagenic Activity and Radical Scavenging Activity of Water Infusions and Phenolics from Ligustrum Plants Leaves. Molecules 2009, 14, 509-518.

AMA Style

Nagy M, Križková L, Mučaji P, Kontšeková Z, Šeršeň F, Krajčovič J. Antimutagenic Activity and Radical Scavenging Activity of Water Infusions and Phenolics from Ligustrum Plants Leaves. Molecules. 2009; 14(1):509-518.

Chicago/Turabian Style

Nagy, Milan; Križková, Lívia; Mučaji, Pavel; Kontšeková, Zuzana; Šeršeň, František; Krajčovič, Juraj. 2009. "Antimutagenic Activity and Radical Scavenging Activity of Water Infusions and Phenolics from Ligustrum Plants Leaves." Molecules 14, no. 1: 509-518.



Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert