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Molecules 2009, 14(1), 509-518; doi:10.3390/molecules14010509

Antimutagenic Activity and Radical Scavenging Activity of Water Infusions and Phenolics from Ligustrum Plants Leaves

1
Department of Pharmacognosy and Botany, Faculty of Pharmacy, Comenius University, Odbojarov 10, 83232 Bratislava, Slovak Republic
2
Institute of Cell Biology, Faculty of Natural Sciences, Comenius University, Mlynská dolina, 84215 Bratislava, Slovak Republic
3
Institute of Chemistry, Faculty of Natural Sciences, Comenius University, Mlynská dolina, 84215 Bratislava, Slovak Republic
*
Author to whom correspondence should be addressed.
Received: 24 November 2008 / Revised: 15 January 2009 / Accepted: 21 January 2009 / Published: 22 January 2009
(This article belongs to the Special Issue Phenolics and Polyphenolics)
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Abstract

Water infusions of Ligustrum delavayanum and Ligustrum vulgare leaves and eight phenolics isolated therefrom have been assayed in vitro on ofloxacin-induced genotoxicity in the unicellular flagellate Euglena gracilis. The tested compounds luteolin, quercetin, luteolin-7-glucoside, luteolin-7-rutinoside, quercetin-3-rutinoside, apigenin-7-rutinoside, tyrosol and esculetin inhibited the mutagenic activity of ofloxacin (43 µM) in E. gracilis. Water infusions from leaves of L. delavayanum and L. vulgare showed higher antimutagenic effect (pt < 0.001). The activity of these samples against ofloxacin (86 µM)-induced genotoxicity was lower, but statistically significant (pt < 0.05), excluding the water infusion of L. delavayanum leaves (pt < 0.01). Efficacy of quercetin, luteolin-7-rutinoside, apigenin-7-rutinoside was insignificant. The antimutagenic effect of most phenolics we studied could be clearly ascribed to their DPPH scavenging activity, substitution patterns and lipophilicity. View Full-Text
Keywords: Ligustrum; Euglena gracilis; Phenolics; Antimutagenicity; Lipophilicity; DPPH Ligustrum; Euglena gracilis; Phenolics; Antimutagenicity; Lipophilicity; DPPH
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MDPI and ACS Style

Nagy, M.; Križková, L.; Mučaji, P.; Kontšeková, Z.; Šeršeň, F.; Krajčovič, J. Antimutagenic Activity and Radical Scavenging Activity of Water Infusions and Phenolics from Ligustrum Plants Leaves. Molecules 2009, 14, 509-518.

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