Abstract: Water infusions of Ligustrum delavayanum and Ligustrum vulgare leaves and eight phenolics isolated therefrom have been assayed in vitro on ofloxacin-induced genotoxicity in the unicellular flagellate Euglena gracilis. The tested compounds luteolin, quercetin, luteolin-7-glucoside, luteolin-7-rutinoside, quercetin-3-rutinoside, apigenin-7-rutinoside, tyrosol and esculetin inhibited the mutagenic activity of ofloxacin (43 µM) in E. gracilis. Water infusions from leaves of L. delavayanum and L. vulgare showed higher antimutagenic effect (pt < 0.001). The activity of these samples against ofloxacin (86 µM)-induced genotoxicity was lower, but statistically significant (pt < 0.05), excluding the water infusion of L. delavayanum leaves (pt < 0.01). Efficacy of quercetin, luteolin-7-rutinoside, apigenin-7-rutinoside was insignificant. The antimutagenic effect of most phenolics we studied could be clearly ascribed to their DPPH scavenging activity, substitution patterns and lipophilicity.
Keywords: Ligustrum; Euglena gracilis; Phenolics; Antimutagenicity; Lipophilicity; DPPH
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Nagy, M.; Križková, L.; Mučaji, P.; Kontšeková, Z.; Šeršeň, F.; Krajčovič, J. Antimutagenic Activity and Radical Scavenging Activity of Water Infusions and Phenolics from Ligustrum Plants Leaves. Molecules 2009, 14, 509-518.
Nagy M, Križková L, Mučaji P, Kontšeková Z, Šeršeň F, Krajčovič J. Antimutagenic Activity and Radical Scavenging Activity of Water Infusions and Phenolics from Ligustrum Plants Leaves. Molecules. 2009; 14(1):509-518.
Nagy, Milan; Križková, Lívia; Mučaji, Pavel; Kontšeková, Zuzana; Šeršeň, František; Krajčovič, Juraj. 2009. "Antimutagenic Activity and Radical Scavenging Activity of Water Infusions and Phenolics from Ligustrum Plants Leaves." Molecules 14, no. 1: 509-518.