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Molecules 2008, 13(2), 360-378; doi:10.3390/molecules13020360
Review

Design, Synthesis and Applications of Hyaluronic Acid-Paclitaxel Bioconjugates†

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,
 and
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Dipartimento di Chimica and Istituto di Chimica Biomolecolare del CNR, Sezione di Roma, Università degli Studi di Roma "La Sapienza”, P.le Aldo Moro 5, BOX n. 34 ROMA 62, I-00185 Roma, Italy
* Author to whom correspondence should be addressed.
Received: 29 January 2008 / Revised: 11 February 2008 / Accepted: 11 February 2008 / Published: 12 February 2008
(This article belongs to the Special Issue Prodrugs)
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Abstract

Paclitaxel (1a), a well known antitumor agent adopted mainly for the treatmentof breast and ovarian cancer, suffers from significant disadvantages such as low solubility,certain toxicity and specific drug-resistance of some tumor cells. To overcome theseproblems extensive research has been carried out. Among the various proposed strategies,the conjugation of paclitaxel (1a) to a biocompatible polymer, such as hyaluronic acid(HA, 2), has also been considered. Coupling a bioactive compound to a biocompatiblepolymer offers, in general, many advantages such as better drug solubilization, betterstabilization, specific localization and controlled release. Hereafter the design, synthesisand applications of hyaluronic acid-paclitaxel bioconjugates are reviewed. An overview ofHA-paclitaxel combinations is also given.
Keywords: Paclitaxel; Hyaluronic Acid; Hyaluronic Acid-Paclitaxel Bioconjugate; Synthesis; Biological Activity. Paclitaxel; Hyaluronic Acid; Hyaluronic Acid-Paclitaxel Bioconjugate; Synthesis; Biological Activity.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Leonelli, F.; La Bella, A.; Migneco, L.M.; Bettolo, R.M. Design, Synthesis and Applications of Hyaluronic Acid-Paclitaxel Bioconjugates†. Molecules 2008, 13, 360-378.

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