Next Article in Journal
Synthesis, Molecular Structure and Spectral Properties of Quaternary Ammonium Derivatives of 1,1-Dimethyl-1,3-propylenediamine
Next Article in Special Issue
Novel Prodrugs for Targeting Diagnostic and Therapeutic Radionuclides to Solid Tumors
Previous Article in Journal / Special Issue
Synthesis and Properties of a New Water-Soluble Prodrug of the Adenosine A2A Receptor Antagonist MSX-2
Molecules 2008, 13(2), 360-378; doi:10.3390/molecules13020360

Design, Synthesis and Applications of Hyaluronic Acid-Paclitaxel Bioconjugates†

Dipartimento di Chimica and Istituto di Chimica Biomolecolare del CNR, Sezione di Roma, Università degli Studi di Roma "La Sapienza”, P.le Aldo Moro 5, BOX n. 34 ROMA 62, I-00185 Roma, Italy
* Author to whom correspondence should be addressed.
Received: 29 January 2008 / Revised: 11 February 2008 / Accepted: 11 February 2008 / Published: 12 February 2008
(This article belongs to the Special Issue Prodrugs)
View Full-Text   |   Download PDF [114 KB, uploaded 18 June 2014]   |   Browse Figures


Paclitaxel (1a), a well known antitumor agent adopted mainly for the treatmentof breast and ovarian cancer, suffers from significant disadvantages such as low solubility,certain toxicity and specific drug-resistance of some tumor cells. To overcome theseproblems extensive research has been carried out. Among the various proposed strategies,the conjugation of paclitaxel (1a) to a biocompatible polymer, such as hyaluronic acid(HA, 2), has also been considered. Coupling a bioactive compound to a biocompatiblepolymer offers, in general, many advantages such as better drug solubilization, betterstabilization, specific localization and controlled release. Hereafter the design, synthesisand applications of hyaluronic acid-paclitaxel bioconjugates are reviewed. An overview ofHA-paclitaxel combinations is also given.
Keywords: Paclitaxel; Hyaluronic Acid; Hyaluronic Acid-Paclitaxel Bioconjugate; Synthesis; Biological Activity. Paclitaxel; Hyaluronic Acid; Hyaluronic Acid-Paclitaxel Bioconjugate; Synthesis; Biological Activity.
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
MDPI and ACS Style

Leonelli, F.; La Bella, A.; Migneco, L.M.; Bettolo, R.M. Design, Synthesis and Applications of Hyaluronic Acid-Paclitaxel Bioconjugates†. Molecules 2008, 13, 360-378.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here


[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert