Next Article in Journal / Special Issue
Design, Synthesis and Applications of Hyaluronic Acid-Paclitaxel Bioconjugates†
Previous Article in Journal
Michael Additions of Amines to Methyl Acrylates Promoted by Microwave Irradiation
Previous Article in Special Issue
Cholesterylbutyrate Solid Lipid Nanoparticles as a Butyric Acid Prodrug
Article Menu

Export Article

Open AccessArticle
Molecules 2008, 13(2), 348-359; https://doi.org/10.3390/molecules13020348

Synthesis and Properties of a New Water-Soluble Prodrug of the Adenosine A2A Receptor Antagonist MSX-2

Pharma-Center Bonn, Pharmaceutical Institute, Pharmaceutical Chemistry I, An der Immenburg 4, D-53121 Bonn, Germany
*
Author to whom correspondence should be addressed.
Received: 29 January 2008 / Revised: 11 February 2008 / Accepted: 11 February 2008 / Published: 12 February 2008
(This article belongs to the Special Issue Prodrugs)
View Full-Text   |   Download PDF [103 KB, uploaded 18 June 2014]   |  

Abstract

The compound L-valine-3-{8-[(E)-2-[3-methoxyphenyl)ethenyl]-7-methyl-1-propargylxanthine-3-yl}propyl ester hydrochloride (MSX-4) was synthesized as an aminoacid ester prodrug of the adenosine A2A receptor antagonist MSX-2. It was found to bestable in artificial gastric acid, but readily cleaved by pig liver esterase. View Full-Text
Keywords: Prodrug; adenosine receptor antagonist; MSX-4; water-solubility; Parkinson’s disease; esterase. Prodrug; adenosine receptor antagonist; MSX-4; water-solubility; Parkinson’s disease; esterase.
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Vollmann, K.; Qurishi, R.; Hockemeyer, J.; Müller, C.E. Synthesis and Properties of a New Water-Soluble Prodrug of the Adenosine A2A Receptor Antagonist MSX-2. Molecules 2008, 13, 348-359.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top