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Molecules 2008, 13(12), 3192-3197; doi:10.3390/molecules13123192
Article

Synthesis of Bis-ureas from Bis(o-nitrophenyl) Carbonate

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Received: 18 November 2008 / Revised: 28 November 2008 / Accepted: 3 December 2008 / Published: 15 December 2008
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Abstract

A general method for the preparation of bis-ureas from bis(o-nitrophenyl) carbonate has been developed. Directional urea synthesis is achieved by sequential amine addition to bis(o-nitrophenyl) carbonate in two steps: in the first step bis(o-nitrophenyl) carbonate is reacted with benzylamine to form benzyl-o-nitrophenyl carbamate; in the second step the carbamate is reacted with a variety of diamines in toluene to yield bis-ureas.
Keywords: Bis(o-nitrophenyl) carbonate; Carbamate; Bis-urea Bis(o-nitrophenyl) carbonate; Carbamate; Bis-urea
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Turoczi, M.-C.; Simon, M.; Badea, V.; Csunderlik, C. Synthesis of Bis-ureas from Bis(o-nitrophenyl) Carbonate. Molecules 2008, 13, 3192-3197.

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