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Acetylcholinesterase Inhibition by Flavonoids from Agrimonia pilosa
Department of Chemistry, Yonsei University, Seoul 120-749, Korea
* Author to whom correspondence should be addressed.
Received: 28 November 2006; in revised form: 21 August 2007 / Accepted: 21 August 2007 / Published: 3 September 2007
Abstract: In a bioassay-guided search for acetylcholinesterase (AChE) inhibitors from 180 medicinal plants, an ethyl acetate extract of whole plants of Agrimonia pilosa ledeb yielded tiliroside (1), 3-methoxy quercetin (2), quercitrin (3) and quercetin (4). We report herein for the first time that all four flavonol compounds showed significant inhibitory effects on AChE, particularly quercetin (4), which showed twice the activity of dehydroevodiamine (DHED).
Keywords: Acetylcholineesterase; Agrimonia pilosa; quercetin; tiliroside; 3-methoxyquercetin;
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Cite This Article
MDPI and ACS Style
Jung, M.; Park, M. Acetylcholinesterase Inhibition by Flavonoids from Agrimonia pilosa. Molecules 2007, 12, 2130-2139.
Jung M, Park M. Acetylcholinesterase Inhibition by Flavonoids from Agrimonia pilosa. Molecules. 2007; 12(9):2130-2139.
Jung, Mankil; Park, Moonso. 2007. "Acetylcholinesterase Inhibition by Flavonoids from Agrimonia pilosa." Molecules 12, no. 9: 2130-2139.