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Molecules 2007, 12(9), 2130-2139; doi:10.3390/12092130

Acetylcholinesterase Inhibition by Flavonoids from Agrimonia pilosa

Department of Chemistry, Yonsei University, Seoul 120-749, Korea
Author to whom correspondence should be addressed.
Received: 28 November 2006 / Revised: 21 August 2007 / Accepted: 21 August 2007 / Published: 3 September 2007
(This article belongs to the Special Issue Phenolics and Polyphenolics)
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In a bioassay-guided search for acetylcholinesterase (AChE) inhibitors from 180 medicinal plants, an ethyl acetate extract of whole plants of Agrimonia pilosa ledeb yielded tiliroside (1), 3-methoxy quercetin (2), quercitrin (3) and quercetin (4). We report herein for the first time that all four flavonol compounds showed significant inhibitory effects on AChE, particularly quercetin (4), which showed twice the activity of dehydroevodiamine (DHED).
Keywords: Acetylcholineesterase; Agrimonia pilosa; quercetin; tiliroside; 3-methoxyquercetin; Acetylcholineesterase; Agrimonia pilosa; quercetin; tiliroside; 3-methoxyquercetin;
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Jung, M.; Park, M. Acetylcholinesterase Inhibition by Flavonoids from Agrimonia pilosa. Molecules 2007, 12, 2130-2139.

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