Molecules 2007, 12(9), 2123-2129; doi:10.3390/12092123
Communication

Synthesis of Ring-Contracted Erythromycin A Derivatives via Microwave-Assisted Intramolecular Transesterification

Kai Bao 1 , Weige Zhang 1,* email, Chuanliang Zhang 1 , Yingwei Qu 1 , Liang Tian 1 , Lan Wu 2 , Xiang Zhao 1  and Maosheng Cheng 1,* email
1 School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China 2 The First Affiliated College, Chinese Medical University, Shenyang 110001, P. R. China
* Authors to whom correspondence should be addressed.
Received: 30 May 2007; in revised form: 16 August 2007 / Accepted: 24 August 2007 / Published: 30 August 2007
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Abstract: The synthesis of ring-contracted derivatives of erythromycin A via intramolecular transesterification under microwave irradiation of 8,9-anhydroerythromycin A 6,9-hemiketal and its derivatives is described. It was found that microwave irradiation could significantly improve the yields and shorten the reaction times under either solvent-containing (method A) or solvent-free (method B) conditions.
Keywords: Ring-contracted derivatives of erythromycin; transesterification; microwave irradiation

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Cite This Article

MDPI and ACS Style

Bao, K.; Zhang, W.; Zhang, C.; Qu, Y.; Tian, L.; Wu, L.; Zhao, X.; Cheng, M. Synthesis of Ring-Contracted Erythromycin A Derivatives via Microwave-Assisted Intramolecular Transesterification. Molecules 2007, 12, 2123-2129.

AMA Style

Bao K, Zhang W, Zhang C, Qu Y, Tian L, Wu L, Zhao X, Cheng M. Synthesis of Ring-Contracted Erythromycin A Derivatives via Microwave-Assisted Intramolecular Transesterification. Molecules. 2007; 12(9):2123-2129.

Chicago/Turabian Style

Bao, Kai; Zhang, Weige; Zhang, Chuanliang; Qu, Yingwei; Tian, Liang; Wu, Lan; Zhao, Xiang; Cheng, Maosheng. 2007. "Synthesis of Ring-Contracted Erythromycin A Derivatives via Microwave-Assisted Intramolecular Transesterification." Molecules 12, no. 9: 2123-2129.

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