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Open AccessCommunication
Molecules 2007, 12(9), 2123-2129; doi:10.3390/12092123

Synthesis of Ring-Contracted Erythromycin A Derivatives via Microwave-Assisted Intramolecular Transesterification

1
School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China
2
The First Affiliated College, Chinese Medical University, Shenyang 110001, P. R. China
*
Authors to whom correspondence should be addressed.
Received: 30 May 2007 / Revised: 16 August 2007 / Accepted: 24 August 2007 / Published: 30 August 2007
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Abstract

The synthesis of ring-contracted derivatives of erythromycin A via intramolecular transesterification under microwave irradiation of 8,9-anhydroerythromycin A 6,9-hemiketal and its derivatives is described. It was found that microwave irradiation could significantly improve the yields and shorten the reaction times under either solvent-containing (method A) or solvent-free (method B) conditions.
Keywords: Ring-contracted derivatives of erythromycin; transesterification; microwave irradiation Ring-contracted derivatives of erythromycin; transesterification; microwave irradiation
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Bao, K.; Zhang, W.; Zhang, C.; Qu, Y.; Tian, L.; Wu, L.; Zhao, X.; Cheng, M. Synthesis of Ring-Contracted Erythromycin A Derivatives via Microwave-Assisted Intramolecular Transesterification. Molecules 2007, 12, 2123-2129.

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