Next Article in Journal
Two Step Synthesis of a Non-symmetric Acetylcholinesterase Reactivator
Next Article in Special Issue
Exploitation of Bile Acid Transport Systems in Prodrug Design
Previous Article in Journal
Synthesis, Antibacterial, Antifungal and Antiviral Activity Evaluation of Some New bis-Schiff Bases of Isatin and Their Derivatives
Previous Article in Special Issue
Synthesis, Characterization, and Saccharide Binding Studies of Bile Acid − Porphyrin Conjugates
Article Menu

Export Article

Open AccessReview
Molecules 2007, 12(8), 1731-1754; doi:10.3390/12081731

Supra-molecular Association and Polymorphic Behaviour In Systems Containing Bile Acid Salts

Dipartimento di Chimica and SOFT-INFM-CNR Research Centre, Università “La Sapienza”, P.le A. Moro 5, Roma, I-00185, Italy
Author to whom correspondence should be addressed.
Received: 9 May 2007 / Revised: 12 July 2007 / Accepted: 12 July 2007 / Published: 7 August 2007
(This article belongs to the Special Issue Bile Acids)
View Full-Text   |   Download PDF [467 KB, uploaded 18 June 2014]   |  


A wide number of supra-molecular association modes are observed in mixtures containing water and bile salts, BS, (with, eventually, other components). Molecular or micellar solutions transform into hydrated solids, fibres, lyotropic liquid crystals and/or gels by raising the concentration, the temperature, adding electrolytes, surfactants, lipids and proteins. Amorphous or ordered phases may be formed accordingly. The forces responsible for this very rich polymorphism presumably arise from the unusual combination of electrostatic, hydrophobic and hydrogen-bond contributions to the system stability, with subsequent control of the supra-molecular organisation modes. The stabilising effect due to hydrogen bonds does not occur in almost all surfactants or lipids and is peculiar to bile acids and salts. Some supra-molecular organisation modes, supposed to be related to malfunctions and dis-metabolic diseases in vivo, are briefly reported and discussed. View Full-Text
Keywords: Bile Salts; Solutions; Micelles; Liquid Crystals; Gels; Fibres; Solids. Bile Salts; Solutions; Micelles; Liquid Crystals; Gels; Fibres; Solids.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Calabresi, M.; Andreozzi, P.; La Mesa, C. Supra-molecular Association and Polymorphic Behaviour In Systems Containing Bile Acid Salts. Molecules 2007, 12, 1731-1754.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top