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Molecules 2007, 12(1), 13-24; doi:10.3390/12010013
Article

Synthesis, Characterization, and Saccharide Binding Studies of Bile Acid − Porphyrin Conjugates

1
,
1
,
1,*  and 1
1 Department of Chemistry, P.O. Box 35, FIN-40014, University of Jyväskylä, Finland 2 Institute of Chemical Technology, Technická 5, 166 28 Prague 6, Czech Republic 3 Zentiva Ltd., Prague, Czech Republic
* Author to whom correspondence should be addressed.
Received: 17 November 2006 / Revised: 2 January 2007 / Accepted: 4 January 2007 / Published: 5 January 2007
(This article belongs to the Special Issue Bile Acids)
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Abstract

Synthesis and characterization of bile acid-porphyrin conjugates (BAPs) are reported. Binding of saccharides with BAPs in aqueous methanol was studied by monitoring changes in the visible absorption spectral of the porphyrin-moieties. Although these studies clearly showed absorbance changes, suggesting quite high if non-selective binding, the mass spectral studies do not unambiguously support these results.
Keywords: Bile acids; porphyrin; saccharide; visible spectroscopy; 1H-NMR; ESI MS. Bile acids; porphyrin; saccharide; visible spectroscopy; 1H-NMR; ESI MS.
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Koivukorpi, J.; Sievänen, E.; Kolehmainen, E.; Král, V. Synthesis, Characterization, and Saccharide Binding Studies of Bile Acid − Porphyrin Conjugates. Molecules 2007, 12, 13-24.

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