Molecules 2007, 12(8), 1720-1730; doi:10.3390/12081720
Article

Synthesis, Antibacterial, Antifungal and Antiviral Activity Evaluation of Some New bis-Schiff Bases of Isatin and Their Derivatives

1,* email, 1, 2, 3 and 3
Received: 11 April 2007; in revised form: 13 May 2007 / Accepted: 15 May 2007 / Published: 7 August 2007
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Twelve new bis-Schiff bases of isatin, benzylisatin and 5-fluoroisatin 3a-3l were prepared by condensation of isatin, benzylisatin and 5-fluoroisatin with primary aromatic amines. The chemical structures of the products were confirmed by 1H- and 13CNMR, IR and mass spectral data. The compounds were screened for antiviral activity against a panel of DNA and RNA viruses. Minimum cytotoxic and minimum virusinhibitory concentrations of these compounds were determined. Compounds 3c and 3i were the most cytotoxic in HEL cells. These newly synthesized bis-Schiff bases were also tested for their antibacterial and antifungal activities. They did not display activity against S. cerevisiae (ATCC 28383) or C. albicans (CIP 1180-79).
Keywords: Isatin; bis-Schiff base; antibacterial; antiviral; antifungal.
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MDPI and ACS Style

Jarrahpour, A.; Khalili, D.; De Clercq, E.; Salmi, C.; Brunel, J.M. Synthesis, Antibacterial, Antifungal and Antiviral Activity Evaluation of Some New bis-Schiff Bases of Isatin and Their Derivatives. Molecules 2007, 12, 1720-1730.

AMA Style

Jarrahpour A, Khalili D, De Clercq E, Salmi C, Brunel JM. Synthesis, Antibacterial, Antifungal and Antiviral Activity Evaluation of Some New bis-Schiff Bases of Isatin and Their Derivatives. Molecules. 2007; 12(8):1720-1730.

Chicago/Turabian Style

Jarrahpour, Aliasghar; Khalili, Dariush; De Clercq, Erik; Salmi, Chanaz; Brunel, Jean M. 2007. "Synthesis, Antibacterial, Antifungal and Antiviral Activity Evaluation of Some New bis-Schiff Bases of Isatin and Their Derivatives." Molecules 12, no. 8: 1720-1730.

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