Abstract: The newly developed and very promising acetylcholinesterase reactivator (E)-1- (2-hydroxyiminomethylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide was prepared using two different pathways via a two-step synthesis involving the appropriate (E)-1-(4-bromobut-2-enyl)-2- or 4-hydroxyiminomethyl-pyridinium bromides. Afterwards, purities and yields of the desired product prepared by both routes were compared. Finally, its potency to reactivate several nerve agent-inhibited acetylcholinesterases was tested.
Keywords: Quaternary; alkylation; acetylcholinesterase; reactivator; oxime; nerve agents
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Musilek, K.; Kuca, K.; Dohnal, V.; Jun, D.; Marek, J.; Koleckar, V. Two Step Synthesis of a Non-symmetric Acetylcholinesterase Reactivator. Molecules 2007, 12, 1755-1761.
Musilek K, Kuca K, Dohnal V, Jun D, Marek J, Koleckar V. Two Step Synthesis of a Non-symmetric Acetylcholinesterase Reactivator. Molecules. 2007; 12(8):1755-1761.
Musilek, Kamil; Kuca, Kamil; Dohnal, Vlastimil; Jun, Daniel; Marek, Jan; Koleckar, Vit. 2007. "Two Step Synthesis of a Non-symmetric Acetylcholinesterase Reactivator." Molecules 12, no. 8: 1755-1761.