Molecules 2007, 12(8), 1755-1761; doi:10.3390/12081755
Communication

Two Step Synthesis of a Non-symmetric Acetylcholinesterase Reactivator

Kamil Musilek 1 , Kamil Kuca 1,* email, Vlastimil Dohnal 1 , Daniel Jun 1 , Jan Marek 2  and Vit Koleckar 3
1 Department of Toxicology, Faculty of Military Health Sciences, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic 2 Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic 3 Center of Advanced Studies, Faculty of Military Health Sciences, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic 4 Department of Food Technology, Mendel University of Agriculture and Forestry Brno, Zemedelska 1, 613 00 Brno, Czech Republic
* Author to whom correspondence should be addressed.
Received: 25 June 2007; in revised form: 1 August 2007 / Accepted: 6 August 2007 / Published: 7 August 2007
PDF Full-text Download PDF Full-Text [58 KB, uploaded 2 October 2008 11:53 CEST]
Abstract: The newly developed and very promising acetylcholinesterase reactivator (E)-1- (2-hydroxyiminomethylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide was prepared using two different pathways via a two-step synthesis involving the appropriate (E)-1-(4-bromobut-2-enyl)-2- or 4-hydroxyiminomethyl-pyridinium bromides. Afterwards, purities and yields of the desired product prepared by both routes were compared. Finally, its potency to reactivate several nerve agent-inhibited acetylcholinesterases was tested.
Keywords: Quaternary; alkylation; acetylcholinesterase; reactivator; oxime; nerve agents

Article Statistics

Click here to load and display the download statistics.

Cite This Article

MDPI and ACS Style

Musilek, K.; Kuca, K.; Dohnal, V.; Jun, D.; Marek, J.; Koleckar, V. Two Step Synthesis of a Non-symmetric Acetylcholinesterase Reactivator. Molecules 2007, 12, 1755-1761.

AMA Style

Musilek K, Kuca K, Dohnal V, Jun D, Marek J, Koleckar V. Two Step Synthesis of a Non-symmetric Acetylcholinesterase Reactivator. Molecules. 2007; 12(8):1755-1761.

Chicago/Turabian Style

Musilek, Kamil; Kuca, Kamil; Dohnal, Vlastimil; Jun, Daniel; Marek, Jan; Koleckar, Vit. 2007. "Two Step Synthesis of a Non-symmetric Acetylcholinesterase Reactivator." Molecules 12, no. 8: 1755-1761.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert