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Two Step Synthesis of a Non-symmetric Acetylcholinesterase Reactivator
Department of Toxicology, Faculty of Military Health Sciences, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic
Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic
Center of Advanced Studies, Faculty of Military Health Sciences, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic
Department of Food Technology, Mendel University of Agriculture and Forestry Brno, Zemedelska 1, 613 00 Brno, Czech Republic
* Author to whom correspondence should be addressed.
Received: 25 June 2007; in revised form: 1 August 2007 / Accepted: 6 August 2007 / Published: 7 August 2007
Abstract: The newly developed and very promising acetylcholinesterase reactivator (E)-1- (2-hydroxyiminomethylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide was prepared using two different pathways via a two-step synthesis involving the appropriate (E)-1-(4-bromobut-2-enyl)-2- or 4-hydroxyiminomethyl-pyridinium bromides. Afterwards, purities and yields of the desired product prepared by both routes were compared. Finally, its potency to reactivate several nerve agent-inhibited acetylcholinesterases was tested.
Keywords: Quaternary; alkylation; acetylcholinesterase; reactivator; oxime; nerve agents
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MDPI and ACS Style
Musilek, K.; Kuca, K.; Dohnal, V.; Jun, D.; Marek, J.; Koleckar, V. Two Step Synthesis of a Non-symmetric Acetylcholinesterase Reactivator. Molecules 2007, 12, 1755-1761.
Musilek K, Kuca K, Dohnal V, Jun D, Marek J, Koleckar V. Two Step Synthesis of a Non-symmetric Acetylcholinesterase Reactivator. Molecules. 2007; 12(8):1755-1761.
Musilek, Kamil; Kuca, Kamil; Dohnal, Vlastimil; Jun, Daniel; Marek, Jan; Koleckar, Vit. 2007. "Two Step Synthesis of a Non-symmetric Acetylcholinesterase Reactivator." Molecules 12, no. 8: 1755-1761.