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Molecules 2007, 12(8), 1755-1761; doi:10.3390/12081755
Communication

Two Step Synthesis of a Non-symmetric Acetylcholinesterase Reactivator

1, 1,* , 1, 1, 2 and 3
Received: 25 June 2007; in revised form: 1 August 2007 / Accepted: 6 August 2007 / Published: 7 August 2007
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Abstract: The newly developed and very promising acetylcholinesterase reactivator (E)-1- (2-hydroxyiminomethylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide was prepared using two different pathways via a two-step synthesis involving the appropriate (E)-1-(4-bromobut-2-enyl)-2- or 4-hydroxyiminomethyl-pyridinium bromides. Afterwards, purities and yields of the desired product prepared by both routes were compared. Finally, its potency to reactivate several nerve agent-inhibited acetylcholinesterases was tested.
Keywords: Quaternary; alkylation; acetylcholinesterase; reactivator; oxime; nerve agents Quaternary; alkylation; acetylcholinesterase; reactivator; oxime; nerve agents
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Musilek, K.; Kuca, K.; Dohnal, V.; Jun, D.; Marek, J.; Koleckar, V. Two Step Synthesis of a Non-symmetric Acetylcholinesterase Reactivator. Molecules 2007, 12, 1755-1761.

AMA Style

Musilek K, Kuca K, Dohnal V, Jun D, Marek J, Koleckar V. Two Step Synthesis of a Non-symmetric Acetylcholinesterase Reactivator. Molecules. 2007; 12(8):1755-1761.

Chicago/Turabian Style

Musilek, Kamil; Kuca, Kamil; Dohnal, Vlastimil; Jun, Daniel; Marek, Jan; Koleckar, Vit. 2007. "Two Step Synthesis of a Non-symmetric Acetylcholinesterase Reactivator." Molecules 12, no. 8: 1755-1761.


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