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Molecules 2007, 12(8), 1755-1761; doi:10.3390/12081755
Communication

Two Step Synthesis of a Non-symmetric Acetylcholinesterase Reactivator

1, 1,* , 1, 1, 2 and 3
1 Department of Toxicology, Faculty of Military Health Sciences, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic 2 Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic 3 Center of Advanced Studies, Faculty of Military Health Sciences, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic 4 Department of Food Technology, Mendel University of Agriculture and Forestry Brno, Zemedelska 1, 613 00 Brno, Czech Republic
* Author to whom correspondence should be addressed.
Received: 25 June 2007 / Revised: 1 August 2007 / Accepted: 6 August 2007 / Published: 7 August 2007
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Abstract

The newly developed and very promising acetylcholinesterase reactivator (E)-1- (2-hydroxyiminomethylpyridinium)-4-(4-hydroxyiminomethylpyridinium)-but-2-ene dibromide was prepared using two different pathways via a two-step synthesis involving the appropriate (E)-1-(4-bromobut-2-enyl)-2- or 4-hydroxyiminomethyl-pyridinium bromides. Afterwards, purities and yields of the desired product prepared by both routes were compared. Finally, its potency to reactivate several nerve agent-inhibited acetylcholinesterases was tested.
Keywords: Quaternary; alkylation; acetylcholinesterase; reactivator; oxime; nerve agents Quaternary; alkylation; acetylcholinesterase; reactivator; oxime; nerve agents
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Musilek, K.; Kuca, K.; Dohnal, V.; Jun, D.; Marek, J.; Koleckar, V. Two Step Synthesis of a Non-symmetric Acetylcholinesterase Reactivator. Molecules 2007, 12, 1755-1761.

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